{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:28:12Z","timestamp":1790616492701,"version":"4.1.0"},"reference-count":700,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>Growth hormone (GH) is produced primarily by anterior pituitary somatotroph cells. Numerous acute human (h) GH treatment and long-term follow-up studies and extensive use of animal models of GH action have shaped the body of GH research over the past 70 years. Work on the GH receptor (R)-knockout (GHRKO) mice and results of studies on GH-resistant Laron Syndrome (LS) patients have helped define many physiological actions of GH including those dealing with metabolism, obesity, cancer, diabetes, cognition and aging\/longevity. In this review, we have discussed several issues dealing with these biological effects of GH and attempt to answer the question of whether decreased GH action may be beneficial.<\/jats:p>","DOI":"10.1530\/eje-18-0018","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T01:40:15Z","timestamp":1519090815000},"page":"R155-R181","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":66,"title":["MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?"],"prefix":"10.1093","volume":"178","author":[{"given":"Reetobrata","family":"Basu","sequence":"first","affiliation":[{"name":"1Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrong","family":"Qian","sequence":"additional","affiliation":[{"name":"1Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Kopchick","sequence":"additional","affiliation":[{"name":"1Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA"},{"name":"2Ohio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"ref1321","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1478-3231.1999.tb00042.x","article-title":"High, persistent hepatocellular proliferation and apoptosis precede hepatocarcinogenesis in growth hormone transgenic mice","volume":"19","year":"1999","journal-title":"Liver"},{"key":"ref6411","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.psyneuen.2006.01.005","article-title":"The effects of growth hormone (GH) deficiency and GH replacement on cognitive performance in adults: a meta-analysis of the current literature","volume":"31","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"ref3551","first-page":"64","article-title":"Adult growth hormone deficiency \u2013 benefits, side effects, and risks of growth hormone replacement","volume":"4","year":"2013","journal-title":"Frontiers in Endocrinology"},{"key":"ref1461","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.4161\/cc.24026","article-title":"Hepatocellular alterations and dysregulation of oncogenic pathways in the liver of transgenic mice overexpressing growth hormone","volume":"12","year":"2013","journal-title":"Cell Cycle"},{"key":"ref1391","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ygcen.2015.06.011","article-title":"Growth hormone and cancer: GH production and action in glioma?","volume":"220","year":"2015","journal-title":"General and Comparative Endocrinology"},{"key":"ref2431","doi-asserted-by":"crossref","first-page":"e24059","DOI":"10.7554\/eLife.24059","article-title":"Longevity is impacted by growth hormone action during early postnatal period","volume":"6","year":"2017","journal-title":"eLife"},{"key":"ref1931","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3390\/cancers30100716","article-title":"Cancer stem cells and epithelial-to-mesenchymal transition (EMT)-phenotypic cells: are they cousins or twins?","volume":"3","year":"2011","journal-title":"Cancers"},{"key":"ref5981","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13059-017-1185-3","article-title":"Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions","volume":"18","year":"2017","journal-title":"Genome Biology"},{"key":"ref1611","doi-asserted-by":"crossref","first-page":"14992","DOI":"10.1073\/pnas.0406396101","article-title":"The oncogenic potential of autocrine human growth hormone in breast cancer","volume":"101","year":"2004","journal-title":"PNAS"},{"key":"ref1971","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.beem.2017.02.005","article-title":"GH and ageing: pitfalls and new insights","volume":"31","year":"2017","journal-title":"Best Practice and Research Clinical Endocrinology and Metabolism"},{"key":"ref2711","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1055\/s-2005-921097","article-title":"The intellectual capacity of patients with Laron syndrome (LS) differs with various molecular defects of the growth hormone receptor gene. 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