{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:47:10Z","timestamp":1787496430856,"version":"build-2736575974"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Pregnancy is rarely reported in acromegaly. Many patients are diagnosed in later life and younger patients may have subfertility due to hypopituitarism. We present a case series of 17 pregnancies in 12 women with acromegaly.<\/jats:p>\n                  <jats:p>Twelve women with acromegaly who completed pregnancy were identified from centres involved in the Irish Pituitary Study. Eleven women had pituitary macroadenomas and one woman had a microadenoma. Only 5\/17 pregnancies had optimal biochemical control of acromegaly preconception, as defined by IGF-1 concentration in the age-related reference level and plasma GH concentration of &lt;2\u2009\u03bcg\/L. In 6\/17 pregnancies, dopamine agonist treatment was continued during pregnancy; all other acromegaly treatments were discontinued during pregnancy.<\/jats:p>\n                  <jats:p>\n                    <jats:italic>Effect of pregnancy on acromegaly<\/jats:italic>\n                    : No patient developed new visual field abnormalities, or symptoms suggestive of tumour expansion during pregnancy. In 9\/12 patients, plasma IGF-1 concentrations that were elevated preconception normalised during pregnancy. There was a reduction in plasma IGF-1 concentrations, though not into the normal range, in a further two pregnancies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Effect of acromegaly on pregnancy<\/jats:italic>\n                    : 15 healthy babies were born at term; one patient underwent emergency C-section at 32 weeks for pre-eclampsia, and one twin pregnancy had an elective C-section at 35 weeks\u2019 gestation. Blood pressure remained within normal limits in the remainder of the pregnancies. Gestational diabetes did not develop in any pregnancy.\n                  <\/jats:p>\n                  <jats:p>Our data suggests that pregnancy in women with acromegaly is generally safe, from a maternal and foetal perspective. Furthermore, biochemical control tends to improve despite the withdrawal of somatostatin analogue therapy during pregnancy.<\/jats:p>","DOI":"10.1530\/eje-18-0688","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T11:03:49Z","timestamp":1546945429000},"page":"K21-K29","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":17,"title":["Pregnancy in acromegaly is safe and is associated with improvements in IGF-1 concentrations"],"prefix":"10.1093","volume":"180","author":[{"given":"Anne Marie","family":"Hannon","sequence":"first","affiliation":[{"name":"1Department of Endocrinology, Beaumont Hospital, Dublin, Ireland"},{"name":"2Royal College of Surgeons in Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Triona","family":"O\u2019Shea","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Beaumont Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire A","family":"Thompson","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Beaumont Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Hannon","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Beaumont Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Dineen","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Beaumont Hospital, Dublin, Ireland"},{"name":"2Royal College of Surgeons in Ireland"},{"name":"3Department of Endocrinology, Adelaide and Meath Hospital, Tallaght, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aftab","family":"Khattak","sequence":"additional","affiliation":[{"name":"4Department of Endocrinology and Diabetes, Cork University Hospital, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Gibney","sequence":"additional","affiliation":[{"name":"3Department of Endocrinology, Adelaide and Meath Hospital, Tallaght, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domhnall J","family":"O\u2019Halloran","sequence":"additional","affiliation":[{"name":"4Department of Endocrinology and Diabetes, Cork University Hospital, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Hunter","sequence":"additional","affiliation":[{"name":"5Department of Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"Thompson","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Beaumont Hospital, Dublin, Ireland"},{"name":"2Royal College of Surgeons in Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Sherlock","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Beaumont Hospital, Dublin, Ireland"},{"name":"2Royal College of Surgeons in Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"ref481","first-page":"2848","article-title":"Effects of oral versus transdermal estrogen on the growth hormone\/insulin-like growth factor I axis in younger and older postmenopausal women: a clinical research center study","volume":"81","year":"1996","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref531","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1507\/endocrj.EJ11-0306","article-title":"Growth of an aggressive tumor during pregnancy in an acromegalic patient","volume":"59","year":"2012","journal-title":"Endocrine 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DISEASE pregnancy a contemporary of https org","author":"Acromegaly","journal-title":"AbuchamJBronsteinMDDiasML MANAGEMENT ENDOCRINE review European Journal Endocrinology"},{"key":"ref411","first-page":"616","article-title":"An outcome-based approach for the creation of fetal growth standards: do singletons and twins need separate standards?","volume":"169","year":"2009","journal-title":"American Journal of Epidemiology"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1210\/er.2003-0035","article-title":"Estrogen regulation of growth hormone action","volume":"25","year":"2004","journal-title":"Endocrine Reviews"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1210\/jc.2009-2331","article-title":"Acromegaly and pregnancy: a retrospective multicenter study of 59 pregnancies in 46 women","volume":"95","year":"2010","journal-title":"Journal of Clinical Endocrinology and 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