{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:43:34Z","timestamp":1790279014423,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n<jats:title>Introduction<\/jats:title>\n<jats:p>Impaired bone microarchitecture is involved in vertebral fracture (VF) development among acromegaly patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Aim of the study<\/jats:title>\n<jats:p>Comparison of DXA-derived bone parameters, areal BMD (aBMD), trabecular bone score (TBS) and 3D-SHAPER parameters in acromegaly patients with healthy controls.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>This cross-sectional study evaluated acromegaly patients and a control group of healthy subjects. In all subjects, a single measurement of pituitary axis hormone levels, bone turnover markers, aBMD, (total hip (TH) and lumbar spine (LS)), TBS and 3D-SHAPER of the proximal femur region was performed. All subjects underwent DXA assessment of VF using the semiquantitative approach.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>One hundred six patients with acromegaly (mean age 56.6 years, BMI 30.2\u2009kg\/m<jats:sup>2<\/jats:sup>) and 104 control subjects (mean age 54.06 years, 28.4 BMI\u2009kg\/m<jats:sup>2<\/jats:sup>) were included. After adjustment for weight, LS aBMD, TBS and TH trabecular volumetric BMD (vBMD) remained lower (<jats:italic>P<\/jats:italic>\u2009=\u20090.0048, &lt;0.0001 and &lt;0.0001, respectively) while cortical thickness (Cth) at TH and neck remained thicker (<jats:italic>P<\/jats:italic>\u2009=\u20090.006) in acromegaly patients compared with controls. The best multivariate model (model 1) discriminating patients with and without acromegaly included TBS, TH trabecular vBMD and TH Cth parameters (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Twenty-two VFs (13 acromegaly subjects) were recognized. In these subjects after adjustment for age, FN aBMD, TH cortical sBMD and TH cortical vBMD remained significantly associated with the prevalent VF (OR\u2009=\u20092.69 (1.07\u20136.78), 2.84 (1.24\u20136.51) and 2.38 (1.11\u20135.10) for neck aBMD, TH cortical sBMD and TH cortical vBMD respectively)). The AUCs were similar for each parameter in this model.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Acromegaly patients, regardless of VF presence, have lower trabecular bone quantitative parameters, but those with VFs had decreased cortical density.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-18-0881","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T16:27:26Z","timestamp":1545236846000},"page":"201-211","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":58,"title":["Non-invasive DXA-derived bone structure assessment of acromegaly patients: a cross-sectional study"],"prefix":"10.1093","volume":"180","author":[{"given":"Martin","family":"Ku\u017ema","sequence":"first","affiliation":[{"name":"1Comenius University Faculty of Medicine, 5th Department of Internal Medicine, University Hospital Bratislava, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Va\u0148uga","sequence":"additional","affiliation":[{"name":"2National Institute of Endocrinology and Diabetology, Lubochna, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"S\u00e1gov\u00e1","sequence":"additional","affiliation":[{"name":"3Comenius University Jessenius Faculty of Medicine, th Department of Internal Medicine, University Hospital Martin, Martin, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du\u0161an","family":"P\u00e1vai","sequence":"additional","affiliation":[{"name":"2National Institute of Endocrinology and Diabetology, Lubochna, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jackuliak","sequence":"additional","affiliation":[{"name":"1Comenius University Faculty of Medicine, 5th Department of Internal Medicine, University Hospital Bratislava, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenko","family":"Killinger","sequence":"additional","affiliation":[{"name":"1Comenius University Faculty of Medicine, 5th Department of Internal Medicine, University Hospital Bratislava, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil C","family":"Binkley","sequence":"additional","affiliation":[{"name":"4Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Winzenrieth","sequence":"additional","affiliation":[{"name":"5Galgo Medical, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry K","family":"Genant","sequence":"additional","affiliation":[{"name":"6University of California San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juraj","family":"Payer","sequence":"additional","affiliation":[{"name":"1Comenius University Faculty of Medicine, 5th Department of Internal Medicine, University Hospital Bratislava, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/180\/3\/EJE-18-0881.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/180\/3\/EJE-18-0881.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:12:46Z","timestamp":1676391166000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/180\/3\/201\/6654028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/eje-18-0881","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3]]}}}