{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:08:11Z","timestamp":1773745691299,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>Previous finding suggests that children growing up under chronic stress tend to experience earlier sexual maturity. The present study aims to examine polygenic risk by experience interaction in predicting pubertal timing, as well as provide insight regarding the relevance of two G\u2009\u00d7\u2009E paradigms.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design and methods<\/jats:title>\n<jats:p>Data were analyzed from a 3-year prospective puberty cohort in Anhui Province, China. Breast Tanner stage and testicular volume (TV) of 997 children were annually assessed. The polygenic risk score (PRS) was computed based on 17 SNPs for early pubertal timing. Hair cortisol concentrations (HCC) were assessed in the first 3\u2009cm hair segment as a biological marker of chronic stress.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Comparing with participants under moderate levels of stress as measured by HCC, the puberty-accelerating effects of chronic stress were only observed among girls with moderate (1.7 months earlier, <jats:italic>P<\/jats:italic>\u2009=\u20090.007) and low genetic susceptibility (2.2 months earlier, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and among boys with high genetic susceptibility (2.0 months earlier, <jats:italic>P<\/jats:italic>\u2009=\u20090.005). Polygenic differences (PRSs) in age at thelarche was most prominent in those with low levels of stress by HCC (9.06, 9.36 and 9.53 years for high, moderate and low PRS, respectively; <jats:italic>F<\/jats:italic>\u2009=\u2009105.06, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), while polygenic differences in age at TV \u22654\u2009mL was strongest in those under chronic stress (10.91, 11.06 and 11.17 years for high, moderate and low PRS, respectively; <jats:italic>F<\/jats:italic>\u2009=\u2009100.48, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Chronic stress predicts earlier age at pubertal onset in a sex-specific and genetic background-dependent manner. The bioecological G\u2009\u00d7\u2009E model for girls and diathesis stress model for boys in pubertal timing warrants further investigation.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-19-0033","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T12:57:51Z","timestamp":1559221071000},"page":"129-137","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":9,"title":["Role of polygenic risk in susceptibility to accelerated pubertal onset following chronic stress exposure"],"prefix":"10.1093","volume":"181","author":[{"given":"Ying","family":"Sun","sequence":"first","affiliation":[{"name":"1Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University"},{"name":"2Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, Anhui Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Fang","sequence":"additional","affiliation":[{"name":"1Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University"},{"name":"2Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, Anhui Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhui","family":"Wan","sequence":"additional","affiliation":[{"name":"1Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University"},{"name":"2Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, Anhui Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puyu","family":"Su","sequence":"additional","affiliation":[{"name":"1Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University"},{"name":"2Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, Anhui Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangbiao","family":"Tao","sequence":"additional","affiliation":[{"name":"1Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University"},{"name":"2Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, Anhui Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/181\/2\/EJE-19-0033.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/181\/2\/EJE-19-0033.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:13:00Z","timestamp":1676391180000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/181\/2\/129\/6654089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/eje-19-0033","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]}}}