{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:08:16Z","timestamp":1788235696407,"version":"build-2803163510"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>Several clinical studies have reported that renal impairments are sometimes observed in patients with primary aldosteronism (PA). We analyzed the prevalence of renal impairments in PA patients and identified parameters that increase the risk for them.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design<\/jats:title>\n<jats:p>This is a retrospective cross-sectional study. We assessed the PA database established by the multicenter Japan PA study (JPAS). Data were also collected from patients with essential hypertension (EHT).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>We compared the prevalences of proteinuria and lowered estimated glomerular filtration rate (eGFR) between patients with PA and age, sex, blood pressure and duration of hypertension-matched patients with EHT. We also performed logistic regression analysis to identify parameters that increase the risk for these renal impairments.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Among 2366 PA patients, the prevalences of proteinuria and lowered eGFR were 10.3 and 11.6%, respectively. The prevalence of proteinuria was significantly higher in PA patients than matched-EHT patients (16.8 vs 4.4%), whereas there was no significant difference in the prevalence of lowered eGFR (17.2 vs 15.0%). The logistic regression analysis also showed that the plasma aldosterone concentration (PAC) significantly increases the risk of proteinuria and lowered eGFR, independent of other known risk factors.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Plasma aldosterone levels are closely associated with renal impairment in patients with PA. This is contrast to our earlier finding that the PAC was not itself linearly associated with cardiovascular events such as stroke or ischemic heart disease. The mechanism underlying the kidney damage in patients with PA may differ from that affecting the cardiovascular system.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-19-0047","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T15:17:28Z","timestamp":1563463048000},"page":"339-350","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":50,"title":["Renal impairment is closely associated with plasma aldosterone concentration in patients with primary aldosteronism"],"prefix":"10.1093","volume":"181","author":[{"given":"Akiyuki","family":"Kawashima","sequence":"first","affiliation":[{"name":"1Department of Diabetes, Endocrinology and Nutrition, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Sone","sequence":"additional","affiliation":[{"name":"1Department of Diabetes, Endocrinology and Nutrition, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuya","family":"Inagaki","sequence":"additional","affiliation":[{"name":"1Department of Diabetes, Endocrinology and Nutrition, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyu","family":"Takeda","sequence":"additional","affiliation":[{"name":"2Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Itoh","sequence":"additional","affiliation":[{"name":"3Department of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Kurihara","sequence":"additional","affiliation":[{"name":"3Department of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Umakoshi","sequence":"additional","affiliation":[{"name":"4Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamasa","family":"Ichijo","sequence":"additional","affiliation":[{"name":"5Department of Endocrinology and Metabolism, Saiseikai Yokohamashi Tobu Hospital, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuyuki","family":"Katabami","sequence":"additional","affiliation":[{"name":"6Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Wada","sequence":"additional","affiliation":[{"name":"7Department of Diabetes and Endocrinology, Sapporo City General Hospital, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"8Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Kawashima","sequence":"additional","affiliation":[{"name":"9Department of Metabolic Medicine, Faculty of Life Science, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Fujita","sequence":"additional","affiliation":[{"name":"10Division of Nephrology and Endocrinology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shozo","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"11Department of Diabetes and Endocrinology, Ehime Prefectural Central Hospital, Matsuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Okamura","sequence":"additional","affiliation":[{"name":"12Department of Endocrinology, Tenriyorozu Hospital, Tenri, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomikazu","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"13Department of Internal Medicine, Matsuyama Red Cross Hospital, Matsuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Yanase","sequence":"additional","affiliation":[{"name":"14Department of Endocrinology and Diabetes Mellitus, Faculty of Medicine, Fukuoka University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichiro","family":"Izawa","sequence":"additional","affiliation":[{"name":"15Department of Endocrinology and Metabolism, Tottori University Hospital, Yonago, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"16Department of Endocrinology and Diabetes Mellitus, isato Kenwa Hospital, Misato, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeatsu","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"17Division of Nephrology, Hypertension, Endocrinology, and Diabetology\/Metabolism, Fukushima Medical University Hospital, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Yamada","sequence":"additional","affiliation":[{"name":"18Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Kai","sequence":"additional","affiliation":[{"name":"19Department of Cardiology, Saiseikai Tondabayahsi Hospital, Tondabayashi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"20Department of Public Health, School of Medicine, International University of Health and Welfare, Narita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhide","family":"Naruse","sequence":"additional","affiliation":[{"name":"4Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan"},{"name":"21Center of Endocrine Diseases, Takeda General Hospital, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of 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