{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:02:17Z","timestamp":1789628537621,"version":"build-2803163510"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>Langerhans cell histiocytosis (LCH) is a rare inflammatory myeloid neoplasm which can infiltrate any organ or tissue. Endocrine involvement has mostly been described in case reports and small retrospective studies. We aimed to describe endocrine manifestations in a large cohort of adulthood onset (AO) and childhood onset (CO) patients with LCH.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design<\/jats:title>\n<jats:p>Single-center observational study conducted between January 2002 and December 2017 at Piti\u00e9-Salp\u00eatri\u00e8re University Hospital (Paris, France), a tertiary care hospital.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Method<\/jats:title>\n<jats:p>Clinical, biological and morphological evaluations of pituitary, gonadal, adrenal and thyroid function evaluations performed in 63 consecutive patients with LCH (AO patients: 40, CO patients: 23). Fifty-eight patients underwent follow-up assessments.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Complete pituitary evaluation was performed in 38\/63 patients (60.3%); at least one anterior pituitary dysfunction (APD) was found in 63.2% of them. In this subgroup of patients, the most prevalent deficiencies were diabetes insipidus (DI) and GHD (55.3% each), followed by gonadotropin deficiency (34.2%) and thyrotropin deficiency (23.7%). In the subgroup of the 25 incompletely evaluated patients, we found DI in 44%, GHD in 50%, gonadotropin deficiency in 30.4% and thyrotropin deficiency in 16%. APD was more common in CO patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.003) but was not systematically associated with DI regardless of the age of onset. Endocrine dysfunction was most often permanent; moreover, occurrence of new deficiencies has been described during follow-up.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The spectrum of endocrine disorders appears to be large in LCH (both in AO and CO patients) and should be evaluated carefully at diagnosis and during follow-up. APD was not always associated with DI.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-19-0177","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T13:20:23Z","timestamp":1562160023000},"page":"275-285","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":40,"title":["Endocrine manifestations in a cohort of 63 adulthood and childhood onset patients with Langerhans cell histiocytosis"],"prefix":"10.1093","volume":"181","author":[{"given":"Yempabou","family":"Sagna","sequence":"first","affiliation":[{"name":"1Service de M\u00e9decine Interne, CHU Yalgado Ouedraogo, UFR Sciences de la Sant\u00e9, Universit\u00e9 Ouaga I Pr Joseph Ki Zerbo, Ouagadougou, Burkina Faso"},{"name":"2Service d\u2019Endocrinologie et M\u00e9decine de la Reproduction, H\u00f4pital Universitaire Piti\u00e9 Salp\u00eatri\u00e8re \u2013 Charles Foix, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Courtillot","sequence":"additional","affiliation":[{"name":"2Service d\u2019Endocrinologie et M\u00e9decine de la Reproduction, H\u00f4pital Universitaire Piti\u00e9 Salp\u00eatri\u00e8re \u2013 Charles Foix, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Y","family":"Drabo","sequence":"additional","affiliation":[{"name":"1Service de M\u00e9decine Interne, CHU Yalgado Ouedraogo, UFR Sciences de la Sant\u00e9, Universit\u00e9 Ouaga I Pr Joseph Ki Zerbo, Ouagadougou, Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdellatif","family":"Tazi","sequence":"additional","affiliation":[{"name":"3Service de Pneumologie, Centre National de R\u00e9f\u00e9rence des Histiocytoses, H\u00f4pital Saint-Louis, Equipe de Recherche en Biostatistiques et Epid\u00e9miologie Clinique, U1153 CRESS, Univ Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Donadieu","sequence":"additional","affiliation":[{"name":"4Service d\u2019H\u00e9mato-Oncologie P\u00e9diatrique, H\u00f4pital Trousseau, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Idbaih","sequence":"additional","affiliation":[{"name":"5Sorbonne Universit\u00e9, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re, ICM, AP-HP, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re \u2013 Charles Foix, Service de Neurologie 2-Mazarin, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleur","family":"Cohen","sequence":"additional","affiliation":[{"name":"6Service de M\u00e9decine Interne, H\u00f4pital Universitaire Piti\u00e9 Salp\u00eatri\u00e8re \u2013 Charles Foix, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahir","family":"Amoura","sequence":"additional","affiliation":[{"name":"6Service de M\u00e9decine Interne, H\u00f4pital Universitaire Piti\u00e9 Salp\u00eatri\u00e8re \u2013 Charles Foix, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Haroche","sequence":"additional","affiliation":[{"name":"6Service de M\u00e9decine Interne, H\u00f4pital Universitaire Piti\u00e9 Salp\u00eatri\u00e8re \u2013 Charles Foix, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Touraine","sequence":"additional","affiliation":[{"name":"2Service d\u2019Endocrinologie et M\u00e9decine de la Reproduction, H\u00f4pital Universitaire Piti\u00e9 Salp\u00eatri\u00e8re \u2013 Charles Foix, Sorbonne Universit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of 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