{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:03:01Z","timestamp":1781758981077,"version":"3.54.5"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n<jats:title>Introduction<\/jats:title>\n<jats:p>The role of vitamin D on bone microarchitecture and fragility is not clear.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>To investigate whether vitamin D deficiency (25(OH)D &lt;20\u2009ng\/mL) increases cortical bone loss and the severity of fractures.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design<\/jats:title>\n<jats:p>Cross-sectional study of 287 elderly women with at least one prevalent low-impact fracture.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Biochemistry, X-rays to identify vertebral fractures (VFs) and to confirm non-vertebral fractures (NonVFs), and high-resolution peripheral quantitative computed tomography (HR-pQCT) to evaluate bone microstructure.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Serum 25(OH)D levels were associated with body mass index (BMI: <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.161, <jats:italic>P<\/jats:italic>\u2009=\u20090.006), PTH (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.165; <jats:italic>P<\/jats:italic>\u2009=\u20090.005), CTX (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.119; <jats:italic>P<\/jats:italic>\u2009=\u20090.043) and vBMD at cortical bone (Dcomp: <jats:italic>r<\/jats:italic>\u2009=\u20090.132; <jats:italic>P<\/jats:italic>\u2009=\u20090.033) and entire bone (D100: <jats:italic>r<\/jats:italic>\u2009=\u20090.162 <jats:italic>P<\/jats:italic>\u2009=\u20090.009) at the distal radius, but not at the tibia. Age and PTH levels were potential confounding variables, but in the multiple linear regressions only BMI (95% CI: 0.11\u20134.16; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), 25(OH)D (95% CI: \u22120.007 to 1.70; <jats:italic>P<\/jats:italic>\u2009=\u20090.05) and CTX (95% CI: \u2212149.04 to 21.80; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) predicted Dcomp, while BMI (95% CI: 1.13\u20134.18; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and 25(OH)D (95% CI: 0.24\u20131.52; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) predicted D100. NonVFs predominated in patients with 25(OH)D &lt;20\u2009ng\/mL (<jats:italic>P<\/jats:italic>\u2009=\u20090.013). Logistic regression analysis showed a decrease in the likelihood of presenting grade 2\u20133 VFs\/NonVFs for every increase in 25(OH)D (OR\u2009=\u20090.962, 95% CI: 0.940\u20130.984; <jats:italic>P<\/jats:italic>\u2009=\u20090.001), BMI (OR\u2009=\u20090.932, 95% CI: 0.885\u20130.981; <jats:italic>P<\/jats:italic>\u2009=\u20090.007) and D100 at radius (OR\u2009=\u20090.994, 95% CI: 0.990\u20130.998; <jats:italic>P<\/jats:italic>\u2009=\u20090.005).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In elderly patients with prevalent fractures, vitamin D deficiency was associated with cortical bone loss and severity of fractures.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-19-0197","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T10:54:46Z","timestamp":1569236086000},"page":"509-517","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":21,"title":["Vitamin D deficiency is associated with cortical bone loss and fractures in the elderly"],"prefix":"10.1093","volume":"181","author":[{"given":"F P","family":"Paranhos-Neto","sequence":"first","affiliation":[{"name":"1Division of Endocrinology, Clementino Fraga Filho University Hospital, UFRJ, Rio de Janeiro, Rio de Janeiro, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Vieira Neto","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology, Clementino Fraga Filho University Hospital, UFRJ, Rio de Janeiro, Rio de Janeiro, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Madeira","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology, Clementino Fraga Filho University Hospital, UFRJ, Rio de Janeiro, Rio de Janeiro, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A B","family":"Moraes","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology, Clementino Fraga Filho University Hospital, UFRJ, Rio de Janeiro, Rio de Janeiro, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L M C","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"2Division of Reumathology, Clementino Fraga Filho University Hospital, UFRJ, Rio de Janeiro, Rio de Janeiro, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I C B","family":"Lima","sequence":"additional","affiliation":[{"name":"3Program of Nuclear Engineering \u2013 COPPE \u2013 UFRJ, Rio de Janeiro, Rio de Janeiro, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C L R","family":"Chagas","sequence":"additional","affiliation":[{"name":"4Research Division, National Institute of Orthopedics and Traumatology, Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Lira","sequence":"additional","affiliation":[{"name":"4Research Division, National Institute of Orthopedics and Traumatology, Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J F","family":"Spitz","sequence":"additional","affiliation":[{"name":"4Research Division, National Institute of Orthopedics and Traumatology, Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A M","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"4Research Division, National Institute of Orthopedics and Traumatology, Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M E L","family":"Duarte","sequence":"additional","affiliation":[{"name":"4Research Division, National Institute of Orthopedics and Traumatology, Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L F","family":"Farias","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology, Clementino Fraga Filho University Hospital, UFRJ, Rio de Janeiro, Rio de Janeiro, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of 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