{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:01:41Z","timestamp":1792717301994,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>To investigate the concordance of serologic and sonographic evidence of Hashimoto\u2019s thyroiditis with its gold standard histopathologic identification.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design<\/jats:title>\n<jats:p>We performed a retrospective analysis on a cohort of 825 consecutive patients in whom TPOAb and thyroid ultrasound were performed, and in whom thyroid nodule evaluation led to surgical and histopathologic analysis. The presence or absence of Hashimoto\u2019s thyroiditis on histopathology was correlated with serologic and sonographic markers. We further assessed the impact of low versus high titers of TPOAb upon this concordance.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Of 825 patients, 277 (33.5%) had histologic confirmation of Hashimoto\u2019s thyroiditis, 235 patients (28.4%) had elevated serum levels of TPOAb, and 197 (23.8%) had sonographic evidence of diffuse heterogeneity. Of those with histopathologic evidence, only 64% had elevated TPOAb (sensitivity: 63.9%; specificity: 89.4%), while only 49% were sonographically diffusely heterogeneous (sensitivity: 49.1%; specificity: 88.9%). A subset of only 102 of 277 (37%) with histologically proven Hashimoto\u2019s thyroiditis was positive for both TPOAb and diffusely heterogeneous. Concordance analysis demonstrated that TPOAb and histopathology had higher agreement (\u03ba\u2009=\u20090.55) than did ultrasound and histopathology (\u03ba\u2009=\u20090.40) for the diagnosis of Hashimoto\u2019s thyroiditis. Higher titers of TPOAb correlated with a higher likelihood of Hashimoto\u2019s thyroiditis, with a best cutoff of 2.11-fold the upper normal level of TPOAb.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Only moderate concordance exists between serological evidence of Hashimoto\u2019s thyroiditis and histopathologic findings, though it increases with higher TPOAb concentration. Diffuse heterogeneity on ultrasound is a less-sensitive diagnostic tool than elevated TPOAb.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-19-0424","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T11:55:52Z","timestamp":1568721352000},"page":"539-544","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":45,"title":["Discordance of serological and sonographic markers for Hashimoto\u2019s thyroiditis with gold standard histopathology"],"prefix":"10.1093","volume":"181","author":[{"given":"Haixia","family":"Guan","sequence":"first","affiliation":[{"name":"1Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Shenyang, China"},{"name":"2Thyroid Section, Brigham & Women\u2019s Hospital & Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie Silva","family":"de Morais","sequence":"additional","affiliation":[{"name":"2Thyroid Section, Brigham & Women\u2019s Hospital & Harvard Medical School, Boston, MA, USA"},{"name":"3Endocrinology Service, Instituto Nacional de C\u00e2ncer and Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"},{"name":"4Endocrinology Service, Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Stuart","sequence":"additional","affiliation":[{"name":"2Thyroid Section, Brigham & Women\u2019s Hospital & Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"2Thyroid Section, Brigham & Women\u2019s Hospital & Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Marqusee","sequence":"additional","affiliation":[{"name":"2Thyroid Section, Brigham & Women\u2019s Hospital & Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew I","family":"Kim","sequence":"additional","affiliation":[{"name":"2Thyroid Section, Brigham & Women\u2019s Hospital & Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik K.","family":"Alexander","sequence":"additional","affiliation":[{"name":"2Thyroid Section, Brigham & Women\u2019s Hospital & Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/181\/5\/EJE-19-0424.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/181\/5\/EJE-19-0424.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:13:38Z","timestamp":1676391218000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/181\/5\/539\/6654067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":0,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1530\/eje-19-0424","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}