{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:01:11Z","timestamp":1792684871181,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>This study is to determine the impact of complications after total thyroidectomy on health-related quality of life (HR-QoL) and to identify significant predictive factors of HR-QoL changes. HR-QoL is usually impaired in patients with thyroid diseases compared to the general population. Thyroidectomy is largely performed in the case of benign thyroid benign and can be associated with long-term complications (vocal cord palsy, hypoparathyroidism).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design<\/jats:title>\n<jats:p>The prospective ThyrQoL multicenter trial (NCT02167529) included 800 patients who underwent total thyroidectomy for benign or malignant non-extensive disease in seven French referral hospitals between 2014 and 2016.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>HR-QoL was assessed using the MOS 36-item short form health survey (SF-36) self-questionnaire with a 6-month follow-up.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>We observed a significant improvement of HR-QoL 6 months after surgery (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Postoperative complications were associated with a non-significant impairment of HR-QoL. In multivariable analysis, Graves\u2019 disease was associated with a significant improvement of HR-QoL (OR\u2009=\u20092.39 [1.49; 3.84]) and thyroid malignant disease with an impairment of HR-QoL (OR\u2009=\u20091.44 [0.99; 2.08]) after thyroidectomy.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>We observed a significant improvement of HR-QoL 6 months after total thyroid surgery for benign thyroid disease.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-19-0587","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T16:32:56Z","timestamp":1575477176000},"page":"195-205","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":32,"title":["Impact of total thyroidectomy on quality of life at 6 months: the prospective ThyrQoL multicentre trial"],"prefix":"10.1093","volume":"182","author":[{"given":"E","family":"Miralli\u00e9","sequence":"first","affiliation":[{"name":"1Chirurgie Canc\u00e9rologique, Digestive et Endocrinienne, H\u00f4tel Dieu, CHU Nantes, Place Alexis Ricordeau, Nantes Cedex 1, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Borel","sequence":"additional","affiliation":[{"name":"1Chirurgie Canc\u00e9rologique, Digestive et Endocrinienne, H\u00f4tel Dieu, CHU Nantes, Place Alexis Ricordeau, Nantes Cedex 1, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Tresallet","sequence":"additional","affiliation":[{"name":"2Chirurgie G\u00e9n\u00e9rale, Visc\u00e9rale et Endocrinienne, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9s Pierre et Marie Curie (Paris 6), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Hamy","sequence":"additional","affiliation":[{"name":"3CHU Angers, Chirurgie Digestive et Endocrinienne, Angers Cedex 09, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Mathonnet","sequence":"additional","affiliation":[{"name":"4Chirurgie Digestive, G\u00e9n\u00e9rale et Endocrinienne, CHU de Limoges \u2013 H\u00f4pital Dupuytren, Limoges Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Lifante","sequence":"additional","affiliation":[{"name":"5Chirurgie G\u00e9n\u00e9rale, Endocrinienne, Digestive et Thoracique, Centre Hospitalier Lyon-Sud, Pierre B\u00e9nite Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Brunaud","sequence":"additional","affiliation":[{"name":"6Service de Chirurgie Digestive, H\u00e9pato-Biliaire, et Endocrinienne, CHU Nancy \u2013 H\u00f4pital de Brabois, Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Men\u00e9gaux","sequence":"additional","affiliation":[{"name":"2Chirurgie G\u00e9n\u00e9rale, Visc\u00e9rale et Endocrinienne, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9s Pierre et Marie Curie (Paris 6), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J B","family":"Hardouin","sequence":"additional","affiliation":[{"name":"7UMR INSERM 1246\u2010SPHERE, Universit\u00e9 de Nantes, Universit\u00e9 de Tours-Institut de Recherche en sant\u00e9 2, Nantes, France"},{"name":"8Plateforme de M\u00e9thodologie et de Biostatistique \u2013 DRCi \u2013 CHU de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Blanchard","sequence":"additional","affiliation":[{"name":"1Chirurgie Canc\u00e9rologique, Digestive et Endocrinienne, H\u00f4tel Dieu, CHU Nantes, Place Alexis Ricordeau, Nantes Cedex 1, France"},{"name":"9Institut du Thorax, INSERM, CNRS, UNIV Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/182\/2\/EJE-19-0587.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/182\/2\/EJE-19-0587.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:13:49Z","timestamp":1676391229000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/182\/2\/195\/6653915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/eje-19-0587","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}