{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:40:13Z","timestamp":1793814013922,"version":"4.6.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,3]]},"abstract":"\nBackground<\/jats:title>\nTo investigate the association between fasting serum insulin and glucose levels with atherosclerotic plaque composition in the carotid artery. Impaired insulin and glucose levels are implicated in the etiology of cardiovascular disease; however, their influence on the formation and composition of atherosclerotic plaque remains unclear.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nIn 1740 participants (mean age 72.9 years, 46% women, 14.4% diabetes mellitus) from the population-based Rotterdam Study, we performed carotid MRI to evaluate the presence of calcification, lipid core, and intraplaque hemorrhage in carotid atherosclerosis. All participants also underwent blood sampling to obtain information on serum insulin and glucose levels. Using logistic regression models, we assessed the association of serum insulin and glucose levels (per s.d.<\/jats:sc> and in tertiles) with the different plaque components, while adjusting for sex, age, intima-media thickness, and cardiovascular risk factors.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nSerum insulin levels were associated with the presence of intraplaque hemorrhage (adjusted odds ratio (OR): 1.42 (95% CI: 1.12\u20131.7)) We found no association with the presence of calcification or lipid core. Sensitivity analyses restricted to individuals without diabetes mellitus yielded similar results. No associations were found between serum glucose levels and any of the plaque components.<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nSerum insulin levels are associated with the presence of vulnerable components of carotid plaque, specifically with intraplaque hemorrhage. These findings suggest a complex role for serum insulin in the pathophysiology of carotid atherosclerosis and in plaque vulnerability.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-19-0620","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T15:33:31Z","timestamp":1580139211000},"page":"343-350","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":10,"title":["Serum insulin levels are associated with vulnerable plaque components in the carotid artery: the Rotterdam Study"],"prefix":"10.1093","volume":"182","author":[{"given":"Blerim","family":"Mujaj","sequence":"first","affiliation":[{"name":"1Departments of Epidemiology, Erasmus MC, Rotterdam, The Netherlands"},{"name":"2Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands"},{"name":"3Department of Cardiovascular Sciences, Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bos","sequence":"additional","affiliation":[{"name":"1Departments of Epidemiology, Erasmus MC, Rotterdam, The Netherlands"},{"name":"2Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands"},{"name":"4Department of Clinical Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Kavousi","sequence":"additional","affiliation":[{"name":"1Departments of Epidemiology, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aad","family":"van der Lugt","sequence":"additional","affiliation":[{"name":"2Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan A","family":"Staessen","sequence":"additional","affiliation":[{"name":"3Department of Cardiovascular Sciences, Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, University of Leuven, Leuven, Belgium"},{"name":"5Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar H","family":"Franco","sequence":"additional","affiliation":[{"name":"1Departments of Epidemiology, Erasmus MC, Rotterdam, The Netherlands"},{"name":"6Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike W","family":"Vernooij","sequence":"additional","affiliation":[{"name":"1Departments of Epidemiology, Erasmus MC, Rotterdam, The Netherlands"},{"name":"2Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/182\/3\/EJE-19-0620.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/182\/3\/EJE-19-0620.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:13:51Z","timestamp":1676391231000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/182\/3\/343\/6653947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/eje-19-0620","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]}}}