{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T21:07:53Z","timestamp":1780520873670,"version":"3.54.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,3]]},"abstract":"\nBackground\/objective<\/jats:title>\nData on metabolic impairments in Cushing\u2019s syndrome and GH deficiency all suggest that the relationship between cortisol and GH\/IGF-I axis in obesity may have a role in the related diseases. However, studies focusing only on one of these hormones are often controversial in paediatrics. We aimed to explore the simultaneous relationship between cortisol and IGF-I with the metabolic alterations in paediatric obesity.<\/jats:p>\n<\/jats:sec>\n\nSubjects\/methods<\/jats:title>\nRetrospective cross-sectional study in a tertiary care center. We recruited 876 (441 males and 435 females) overweight and obese children and adolescents. A complete clinical and biochemical evaluation including OGTT was performed. Cortisol and IGF-I SDS were divided in quartiles and then crossed to explore the reciprocal influence of high\/high, low\/low, and high\/low levels of each one on the metabolic alterations of obesity.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nSubjects in the higher quartiles of IGF-I-SDS and cortisol had an increased risk of hypertension, hypercholesterolemia, high levels of triglycerides, and reduced HDL cholesterol. Diversely, lower IGF-I-SDS quartiles were associated with higher blood glucose, insulin, insulin resistance, and reduced insulin sensitivity levels with the rise of cortisol quartiles.<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nWe observed that apart from glucose metabolism that is associated with low IGF-I and high cortisol levels, the other parameters known to be associated with increased cardiovascular risk were related to high levels of both IGF-I and cortisol, even if within normal range. Cortisol and IGF-I play a complex role in the comorbidities of obesity, and the evaluation of both variables could clarify some of the discordant results.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-19-0792","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T15:49:17Z","timestamp":1576856957000},"page":"255-264","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":20,"title":["The relationship between cortisol and IGF-I influences metabolic alteration in pediatric overweight and obesity"],"prefix":"10.1093","volume":"182","author":[{"given":"Roberta","family":"Ricotti","sequence":"first","affiliation":[{"name":"1SCDU of Pediatrics, Department of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Solito","sequence":"additional","affiliation":[{"name":"1SCDU of Pediatrics, Department of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mariotti Zani","sequence":"additional","affiliation":[{"name":"2SCDU of Endocrinology, Department of Translational Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Caputo","sequence":"additional","affiliation":[{"name":"2SCDU of Endocrinology, Department of Translational Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Genoni","sequence":"additional","affiliation":[{"name":"1SCDU of Pediatrics, Department of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Barone-Adesi","sequence":"additional","affiliation":[{"name":"3Epidemiology, Department of Translational Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Mancioppi","sequence":"additional","affiliation":[{"name":"1SCDU of Pediatrics, Department of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Agosti","sequence":"additional","affiliation":[{"name":"2SCDU of Endocrinology, Department of Translational Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Aimaretti","sequence":"additional","affiliation":[{"name":"2SCDU of Endocrinology, Department of Translational Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta","family":"Bellone","sequence":"additional","affiliation":[{"name":"1SCDU of Pediatrics, Department of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Prodam","sequence":"additional","affiliation":[{"name":"1SCDU of Pediatrics, Department of Health Sciences"},{"name":"2SCDU of Endocrinology, Department of Translational Medicine"},{"name":"4Interdisciplinary Research Center of Autoimmune and Allergic Diseases, University of Piemonte Orientale, Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/182\/3\/EJE-19-0792.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/182\/3\/EJE-19-0792.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:14:04Z","timestamp":1676391244000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/182\/3\/255\/6653946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/eje-19-0792","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]}}}