{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T23:02:05Z","timestamp":1781478125720,"version":"3.54.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>Differences of Sex Development (DSD) comprise a variety of congenital conditions characterized by atypical chromosomal, gonadal, or anatomical sex. Diagnosis and monitoring of treatment of patients suspected of DSD conditions include clinical examination, measurement of peptide and steroid hormones, and genetic analysis. This position paper on peptide hormone analyses in the diagnosis and control of patients with DSD was jointly prepared by specialists in the field of DSD and\/or peptide hormone analysis from the European Cooperation in Science and Technology (COST) Action DSDnet (BM1303) and the European Reference Network on rare Endocrine Conditions (Endo-ERN). The goal of this position paper on peptide hormone analysis was to establish laboratory guidelines that may contribute to improve optimal diagnosis and treatment control of DSD. The essential peptide hormones used in the management of patients with DSD conditions are follicle-stimulating hormone, luteinising hormone, anti-M\u00fcllerian hormone, and Inhibin B. In this context, the following position statements have been proposed: serum and plasma are the preferred matrices; the peptide hormones can all be measured by immunoassay, while use of LC-MS\/MS technology has yet to be implemented in a diagnostic setting; sex- and age-related reference values are mandatory in the evaluation of these hormones; and except for Inhibin B, external quality assurance programs are widely available.<\/jats:p>","DOI":"10.1530\/eje-19-0831","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T11:34:56Z","timestamp":1586518496000},"page":"P1-P15","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":28,"title":["Peptide hormone analysis in diagnosis and treatment of Differences of Sex Development: joint position paper of EU COST Action \u2018DSDnet\u2019 and European Reference Network on Rare Endocrine Conditions"],"prefix":"10.1093","volume":"182","author":[{"given":"T H","family":"Johannsen","sequence":"first","affiliation":[{"name":"1Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"},{"name":"2International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A-M","family":"Andersson","sequence":"additional","affiliation":[{"name":"1Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"},{"name":"2International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S F","family":"Ahmed","sequence":"additional","affiliation":[{"name":"3Developmental Endocrinology Research Group, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y B","family":"de Rijke","sequence":"additional","affiliation":[{"name":"4Department of Clinical Chemistry, Erasmus MC, University Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R F","family":"Greaves","sequence":"additional","affiliation":[{"name":"5Victorian Clinical Genetics Services, Murdoch Children\u2019s Research Institute, Parkville, Victoria, Australia"},{"name":"6School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia"},{"name":"7Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M F","family":"Hartmann","sequence":"additional","affiliation":[{"name":"8Steroid Research & Mass Spectrometry Unit, Laboratory for Translational Hormone Analytics, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Hiort","sequence":"additional","affiliation":[{"name":"9Division of Pediatric Endocrinology and Diabetology, Department of Paediatrics and Adolescent Medicine, University of Luebeck, Luebeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P-M","family":"Holterhus","sequence":"additional","affiliation":[{"name":"10Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Christian-Albrechts-University, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N P","family":"Krone","sequence":"additional","affiliation":[{"name":"11Academic Unit of Child Health, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kulle","sequence":"additional","affiliation":[{"name":"10Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Christian-Albrechts-University, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L","family":"Ljubicic","sequence":"additional","affiliation":[{"name":"1Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"},{"name":"2International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Mastorakos","sequence":"additional","affiliation":[{"name":"12Unit of Endocrinology, Diabetes Mellitus and Metabolism, Aretaieon Hospital, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"McNeilly","sequence":"additional","affiliation":[{"name":"13Department of Biochemistry, Queen Elizabeth University Hospital, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Pereira","sequence":"additional","affiliation":[{"name":"14Department of Medicine, Division of Endocrinology, Leiden University Medical Centre, Leiden, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Saba","sequence":"additional","affiliation":[{"name":"15Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S A","family":"Wudy","sequence":"additional","affiliation":[{"name":"8Steroid Research & Mass Spectrometry Unit, Laboratory for Translational Hormone Analytics, Division of Pediatric Endocrinology and Diabetology, 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