{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T08:15:13Z","timestamp":1784448913219,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>The carotid bodies (CBs) are peripheral chemoreceptor organs classically described as being O<jats:sub>2<\/jats:sub> sensors, which are increasingly emerging as core players in metabolic control. Herein we evaluated CB activity in prediabetes patients and determined its correlation with dysmetabolism clinical features.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design and methods<\/jats:title>\n<jats:p>Prediabetes patients were recruited at the Cardiology Service, Hospital Santa Marta, Centro Hospitalar Lisboa Central, EPE (CHLC-EPE). The study was approved by CHLC-EPE and NOVA Medical School Ethics Committee. Thirty-three prediabetic and 14 age-matched, non-prediabetic, volunteers had their peripheral chemosensitivity evaluated by the Dejours test. Serum biomarkers of metabolic disease, insulin sensitivity (HOMA-IR), blood pressure, carotid intima-media thickness (cIMT) and glucose tolerance were assessed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>CB chemosensitivity was significantly increased in prediabetic group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Fasting blood, glucose intolerance, fasting insulin and HOMA-IR were significantly higher in prediabetes patients. Insulin resistance correlated both with peripheral chemosensitivity, assessed by the Dejours test (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and with abdominal circumference (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). HbA1c correlated with HOMA-IR (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and left cIMT (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in prediabetes patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>We conclude that CB is overactive in prediabetes subjects and that peripheral chemosensitivity correlates with fasting insulin and insulin resistance representing a novel non-invasive functional biomarker to forecast early metabolic disease.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-19-0976","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T16:13:05Z","timestamp":1585239185000},"page":"549-557","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":45,"title":["Carotid body chemosensitivity: early biomarker of dysmetabolism in humans"],"prefix":"10.1093","volume":"182","author":[{"given":"Jo\u00e3o P","family":"Cunha-Guimaraes","sequence":"first","affiliation":[{"name":"1CEDOC, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria P","family":"Guarino","sequence":"additional","affiliation":[{"name":"1CEDOC, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, Lisbon, Portugal"},{"name":"2ciTechCare, Escola Superior de Sa\u00fade de Leiria, Instituto Polit\u00e9cnico de Leiria, Leiria, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana T","family":"Tim\u00f3teo","sequence":"additional","affiliation":[{"name":"3Servi\u00e7o de Cardiologia, Hospital Santa Marta, Centro Hospital Lisboa Central, EPE, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iolanda","family":"Caires","sequence":"additional","affiliation":[{"name":"1CEDOC, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana F","family":"Sacramento","sequence":"additional","affiliation":[{"name":"1CEDOC, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"1CEDOC, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mafalda","family":"Selas","sequence":"additional","affiliation":[{"name":"3Servi\u00e7o de Cardiologia, Hospital Santa Marta, Centro Hospital Lisboa Central, EPE, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o C P","family":"Santiago","sequence":"additional","affiliation":[{"name":"1CEDOC, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Mota-Carmo","sequence":"additional","affiliation":[{"name":"1CEDOC, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, Lisbon, Portugal"},{"name":"3Servi\u00e7o de Cardiologia, Hospital Santa Marta, Centro Hospital Lisboa Central, EPE, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia V","family":"Conde","sequence":"additional","affiliation":[{"name":"1CEDOC, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/182\/6\/EJE-19-0976.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/182\/6\/EJE-19-0976.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:14:17Z","timestamp":1676391257000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/182\/6\/549\/6654462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1530\/eje-19-0976","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6]]}}}