{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:35:32Z","timestamp":1760189732023},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7]]},"abstract":"\nObjective<\/jats:title>\nThe neurophysiological mechanisms underlying cognitive dysfunction in primary hyperparathyroidism (PHPT) and the brain regions affected are not clear. We assessed neural activation during cognitive testing (matrix reasoning, paired associates, and logical memory) using functional MRI (fMRI) in 23 patients with PHPT and 23 healthy controls. A subset with PHPT was re-assessed 6 months post-parathyroidectomy (PTX).<\/jats:p>\n<\/jats:sec>\n\nDesign<\/jats:title>\nThis is an observational study comparing neural activation by fMRI in patients with PHPT to normative controls. Postmenopausal women were studied at a tertiary referral center.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nThere were no between-group differences in cognitive task performance. Patients with PHPT had lower neural activation vs controls (max Z\u2009=\u20094.02, all P<\/jats:italic>\u2009<\u20090.01) during matrix reasoning in brain regions involved in executive function (left frontal lobe (k\u2009=\u200957) and right medial frontal gyrus (k\u2009=\u200972)) and motor function (right precentral gyrus (k\u2009=\u200951)). During paired associates (verbal memory), those with PHPT had greater activation in the right inferior parietal lobule (language\/mathematical operations; k\u2009=\u200965, P<\/jats:italic>\u2009<\u20090.01). Greater activation in this region bilaterally correlated with higher PTH (k\u2009=\u200996, P<\/jats:italic>\u2009<\u20090.01). Post-PTX, activation decreased during matrix reasoning, but in different regions than those affected pre-PTX.<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nPHPT is associated with differences in task-related neural activation patterns, but no difference in cognitive performance. While this may indicate compensation to maintain the same cognitive function, there was no clear improvement in neural activation after PTX. Larger, longitudinal studies that include PHPT patients followed without surgery are needed to determine if PTX could prevent worsening of altered neural activation patterns in PHPT.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-20-0123","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T16:05:41Z","timestamp":1588176341000},"page":"21-30","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":6,"title":["Functional magnetic resonance imaging in primary hyperparathyroidism"],"prefix":"10.1093","volume":"183","author":[{"given":"Yunglin","family":"Gazes","sequence":"first","affiliation":[{"name":"1Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghao","family":"Liu","sequence":"additional","affiliation":[{"name":"2Division of Endocrinology, Department of Medicine, Hofstra Northwell School of Medicine at Hofstra University, Hempstead, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Sum","sequence":"additional","affiliation":[{"name":"3Division of Endocrinology, Department of Medicine, New York University Langone Medical Center, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Cong","sequence":"additional","affiliation":[{"name":"4Division of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Kuo","sequence":"additional","affiliation":[{"name":"5Department of Surgery, Columbia University Irving Medical Center, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A","family":"Lee","sequence":"additional","affiliation":[{"name":"5Department of Surgery, Columbia University Irving Medical Center, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shonni","family":"Silverberg","sequence":"additional","affiliation":[{"name":"4Division of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaakov","family":"Stern","sequence":"additional","affiliation":[{"name":"1Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcella","family":"Walker","sequence":"additional","affiliation":[{"name":"4Division of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/183\/1\/EJE-20-0123.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/183\/1\/EJE-20-0123.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:14:36Z","timestamp":1676391276000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/183\/1\/21\/6653735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-0123","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]}}}