{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:14:00Z","timestamp":1783487640366,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n<jats:title>Context<\/jats:title>\n<jats:p>In patients treated with antipsychotics, the rare occurrence of a macroprolactinoma represents a therapeutic challenge.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>Our aim was to evaluate the efficacy and psychiatric safety of dopamine agonists (DAs) prescribed for large macroprolactinomas in patients with psychosis treated with antipsychotics.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design<\/jats:title>\n<jats:p>This was a multicenter (France and Belgium) retrospective study.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Patients<\/jats:title>\n<jats:p>Eighteen patients treated with antipsychotics were included.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Under DA, median PRL levels decreased from 1247 (117\u201381 132) to 42 (4\u2013573) ng\/mL (<jats:italic>P<\/jats:italic>\u2009=\u20090.008), from 3850 (449\u201338 000) to 141 (60\u20136000) ng\/mL (<jats:italic>P<\/jats:italic>\u2009=\u20090.037) and from 1664 (94\u20139400) to 1215 (48\u20135640) ng\/mL (<jats:italic>P<\/jats:italic>\u2009=\u20090.56) when given alone (<jats:italic>n<\/jats:italic>\u2009=\u20098), before surgery (<jats:italic>n<\/jats:italic>\u2009=\u20097), or after surgery (<jats:italic>n<\/jats:italic>\u2009=\u20096), respectively. The prolactinoma median largest diameter decreased by 28% (0\u201357) in patients under DAs alone (<jats:italic>P<\/jats:italic>\u2009=\u20090.02) but did not change when given after surgery. Optic chiasm decompression was achieved in 82% of patients. Five patients (28%) were admitted for psychotic relapse while receiving DAs (but three of them had stopped antipsychotic treatment at that time). A more severe underlying psychosis, rather than the DA treatment itself, may explain such psychiatric admissions.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Even if the DA efficacy on PRL levels and tumor volume in patients with macroprolactinoma under antipsychotic drugs is less impressive than that typically observed, it may be considered satisfactory for half of our patients, particularly in cases of optic chiasm compression. Psychotic exacerbation was unusual in these patients, occurring mostly in those with the most severe psychotic forms. DAs may therefore be used as antitumor treatment for macroprolactinoma in patients with visual involvement, severe headaches or invasion into the skull base who receive antipsychotics.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-20-0125","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T17:16:43Z","timestamp":1591031803000},"page":"221-231","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and safety of dopamine agonists in patients treated with antipsychotics and presenting a macroprolactinoma"],"prefix":"10.1093","volume":"183","author":[{"given":"Lucie","family":"Allard","sequence":"first","affiliation":[{"name":"1Assistance Publique H\u00f4pitaux de Paris, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse HYPO, H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Albarel","sequence":"additional","affiliation":[{"name":"2Assistance Publique H\u00f4pitaux de Marseille, Service Endocrinologie, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse HYPO, H\u00f4pital de la Conception, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Bertherat","sequence":"additional","affiliation":[{"name":"3Assistance Publique H\u00f4pitaux de Paris, Service d\u2019Endocrinologie et Maladies M\u00e9taboliques, H\u00f4pitaux universitaires Paris-Centre, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe Jean","family":"Caron","sequence":"additional","affiliation":[{"name":"4CHU Toulouse, Endocrinology and Metabolic Diseases, Service d\u2019Endocrinologie, CHU Larrey, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Cortet","sequence":"additional","affiliation":[{"name":"5CHRU de Lille, Endocrinology, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Courtillot","sequence":"additional","affiliation":[{"name":"6Assistance Publique H\u00f4pitaux de Paris, Endocrinology and Reproductive Medicine, Hopitaux Universitaires Pitie Salp\u00e9tri\u00e8re-Charles Foix, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Delemer","sequence":"additional","affiliation":[{"name":"7CHU de Reims, Service d\u2019Endocrinologie, H\u00f4pital Robert Debr\u00e9, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Jublanc","sequence":"additional","affiliation":[{"name":"8Assistance Publique H\u00f4pitaux de Paris, Endocrinologie, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Maiter","sequence":"additional","affiliation":[{"name":"9Saint-Luc University Hospital, Endocrinology, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Laure","family":"Nunes","sequence":"additional","affiliation":[{"name":"10CHU de Bordeaux, Department of Endocrinology, H\u00f4pital Haut-L\u00e9v\u00eaque, 33604 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Raverot","sequence":"additional","affiliation":[{"name":"11Hospices Civils de Lyon, F\u00e9d\u00e9ration d\u2019Endocrinologie, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse HYPO, Groupement Hospitalier Est, Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Sarfati","sequence":"additional","affiliation":[{"name":"12Assistance Publique H\u00f4pitaux de Paris, Endocrinology, H\u00f4pital Saint-Antoine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Salenave","sequence":"additional","affiliation":[{"name":"1Assistance Publique H\u00f4pitaux de Paris, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse HYPO, H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Corruble","sequence":"additional","affiliation":[{"name":"13Assistance Publique H\u00f4pitaux de Paris, Service Hospitalo-Universitaire de Psychiatrie et Addictologie, H\u00f4pitaux Universitaires Paris-Saclay, H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"},{"name":"14Universit\u00e9 Paris-Saclay, Univ. Paris-Sud, CESP, Equipe MOODS, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Choucha","sequence":"additional","affiliation":[{"name":"13Assistance Publique H\u00f4pitaux de Paris, Service Hospitalo-Universitaire de Psychiatrie et Addictologie, H\u00f4pitaux Universitaires Paris-Saclay, H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"},{"name":"14Universit\u00e9 Paris-Saclay, Univ. Paris-Sud, CESP, Equipe MOODS, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chanson","sequence":"additional","affiliation":[{"name":"1Assistance Publique H\u00f4pitaux de Paris, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse HYPO, H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"},{"name":"15Universit\u00e9 Paris-Saclay, Univ. Paris-Sud, Inserm, Signalisation Hormonale, Physiopathologie Endocrinienne et M\u00e9tabolique, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/183\/2\/EJE-20-0125.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/183\/2\/EJE-20-0125.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:14:36Z","timestamp":1676391276000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/183\/2\/221\/6653769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-0125","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]}}}