{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:55:00Z","timestamp":1761519300876},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>Autoimmune conditions tend to cluster in subjects with Addison\u2019s disease (AD) and probably also among their relatives. The aim of the study was to estimate the frequency of the endocrine gland-specific autoantibodies in first-degree relatives of patients with AD.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Autoantibodies were investigated in 113 family members using RIA and ELISA assays. The control group comprised 143 age-matched volunteers.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Autoimmune diseases were diagnosed in 38.1% relatives. Hashimoto\u2019s thyroiditis was found in 20.3%, Graves\u2019 disease in 8.0%, vitiligo and type 1 diabetes in 3.5%, whereas AD, rheumatoid arthritis and atrophic gastritis with pernicious anaemia in 2.7% each.<\/jats:p>\n<jats:p>All studied antibodies except for islet antigen-2 (<jats:italic>P<\/jats:italic>\u2009=\u20090.085) were significantly more frequent in AD relatives than in controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Antibodies to 21-hydroxylase were detected in 6.2% relatives, thyroid peroxidase in 28.3%, thyroglobulin in 19.5%, glutamic acid decarboxylase in 8.0%, and zinc transporter-8 in 7.1%. Two and more autoantibodies were detected in 18.6% subjects. Significant gender difference was revealed only for aTPO, more common in female relatives (<jats:italic>P<\/jats:italic>\u2009=\u20090.014; OR: 3.16; 95% CI: 1.23\u20138.12). Circulating autoantibodies were found more frequently in the relatives of affected males (<jats:italic>P<\/jats:italic>\u2009=\u20090.008; OR: 3.31; 95% CI: 1.33\u20138.23), and in family members of patients with polyendocrine autoimmunity (<jats:italic>P<\/jats:italic>\u2009=\u20090.009; OR: 3.55; 95% CI: 1.31\u20139.57).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>This study provides evidence of increased susceptibility for the endocrine autoimmunity, especially thyroid disease, in close relatives of patients with AD. Relatives of the male AD patients and of those with autoimmune polyendocrine syndrome are at particular risk and should undergo periodic screening for autoimmune endocrine disorders.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-20-0150","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T16:57:14Z","timestamp":1588265834000},"page":"73-81","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":5,"title":["Increased risk of endocrine autoimmunity in first-degree relatives of patients with autoimmune Addison\u2019s disease"],"prefix":"10.1093","volume":"183","author":[{"given":"Marta","family":"Fichna","sequence":"first","affiliation":[{"name":"1Department of Endocrinology, Metabolism and Internal Medicine, Pozna\u0144 University of Medical Sciences, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr P","family":"Ma\u0142ecki","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Metabolism and Internal Medicine, Pozna\u0144 University of Medical Sciences, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirela","family":"M\u0142odzikowska","sequence":"additional","affiliation":[{"name":"2Central Laboratory of the Poznan University of Medical Sciences Paediatric Hospital, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boles\u0142aw","family":"G\u0119barski","sequence":"additional","affiliation":[{"name":"3Outpatient Medical Centre Remedium, Pawlowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Rucha\u0142a","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Metabolism and Internal Medicine, Pozna\u0144 University of Medical Sciences, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Fichna","sequence":"additional","affiliation":[{"name":"4Department of Paediatric Diabetes and Obesity, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/183\/1\/EJE-20-0150.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/183\/1\/EJE-20-0150.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:14:39Z","timestamp":1676391279000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/183\/1\/73\/6653696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-0150","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]}}}