{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:47:26Z","timestamp":1785894446135,"version":"3.56.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>The incidence of differentiated thyroid carcinoma (DTC) has increased rapidly over the past several years. Thus far, the only conclusively established risk factor for developing DTC is exposure to ionizing radiation, especially when the exposure occurs in childhood. Since the number of childhood cancer survivors (CCS) is increasing due to improvements in treatment and supportive care, the number of patients who will develop DTC after surviving childhood cancer (secondary thyroid cancer) is also expected to rise. Currently, there are no recommendations for management of thyroid cancer specifically for patients who develop DTC as a consequence of cancer therapy during childhood. Since complications or late effects from prior cancer treatment may elevate the risk of toxicity from DTC therapy, the medical history of CCS should be considered carefully in choosing DTC treatment. In this paper, we emphasize how the occurrence and treatment of the initial childhood malignancy affects the medical and psychosocial factors that will play a role in the diagnosis and treatment of a secondary DTC. We present considerations for clinicians to use in the management of patients with secondary DTC, based on the available evidence combined with experience-based opinions of the authors.<\/jats:p>","DOI":"10.1530\/eje-20-0237","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T17:06:44Z","timestamp":1591376804000},"page":"P1-P10","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":11,"title":["Clinical considerations for the treatment of secondary differentiated thyroid carcinoma in childhood cancer survivors"],"prefix":"10.1093","volume":"183","author":[{"given":"Hanneke M","family":"van Santen","sequence":"first","affiliation":[{"name":"1Department of Pediatric Endocrinology, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht, and Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik K","family":"Alexander","sequence":"additional","affiliation":[{"name":"2Department of Endocrinology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A","family":"Rivkees","sequence":"additional","affiliation":[{"name":"3Department of Pediatrics, University of Florida, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Frey","sequence":"additional","affiliation":[{"name":"4Department of Pediatric Oncology, Vienna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C","family":"Clement","sequence":"additional","affiliation":[{"name":"5Department of Pediatrics, Free University Hospital Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda P","family":"Dierselhuis","sequence":"additional","affiliation":[{"name":"6Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal A","family":"Lebbink","sequence":"additional","affiliation":[{"name":"1Department of Pediatric Endocrinology, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht, and Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thera P","family":"Links","sequence":"additional","affiliation":[{"name":"7Department of Endocrinology, University of Groningen, University Medical Center, Groningen, Netherlands Department of endocrinology, UMCG, Groningen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Lorenz","sequence":"additional","affiliation":[{"name":"8Department of Visceral-, Vascular-, and Endocrine Surgery, Universityclinic Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin P","family":"Peeters","sequence":"additional","affiliation":[{"name":"9Department of Endocrinology, Erasmus Medical Center, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Reiners","sequence":"additional","affiliation":[{"name":"10Department of Nuclear Medicine, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno R","family":"Vriens","sequence":"additional","affiliation":[{"name":"11Department of Endocrine Surgery, UMC Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Nathan","sequence":"additional","affiliation":[{"name":"12Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur B","family":"Schneider","sequence":"additional","affiliation":[{"name":"13Department of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Verburg","sequence":"additional","affiliation":[{"name":"14Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/183\/3\/EJE-20-0237.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/183\/3\/EJE-20-0237.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:14:45Z","timestamp":1676391285000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/183\/3\/P1\/6653694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-0237","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}