{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:50:17Z","timestamp":1789091417731,"version":"build-2803163510"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10]]},"abstract":"\nContext:<\/jats:italic><\/jats:title>\nUnilateral aldosteronomas should suppress renin and contralateral aldosterone secretion. Complete aldosterone suppression in contralateral adrenal vein sample (AVS) could predict surgical outcomes.<\/jats:p>\n<\/jats:sec>\n\nObjectives:<\/jats:italic><\/jats:title>\nTo retrospectively evaluate the prevalence of basal contralateral suppression using Aldosterone (A)contralateral(CL)<\/jats:sub>\/Aperipheral(P)<\/jats:sub> as compared to (A\/Cortisol(C)CL<\/jats:sub>)\/(A\/C)P<\/jats:sub> ratio in primary aldosteronism (PA) patients studied in two Canadian centers. To determine the best cut-off to predict clinical and biochemical surgical cure. To compare the accuracy of ACL<\/jats:sub>\/AP<\/jats:sub> to the basal and post-ACTH lateralization index (LI) in predicting surgical cure.<\/jats:p>\n<\/jats:sec>\n\nMethods:<\/jats:italic><\/jats:title>\nIn total, 330 patients with PA and successful AVS were included; 124 lateralizing patients underwent surgery. Clinical and biochemical cure at 3 and 12 months were evaluated using the PASO criteria.<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:italic><\/jats:title>\nUsing ACL<\/jats:sub>\/AP<\/jats:sub> and (A\/C)CL<\/jats:sub>\/(A\/C)P<\/jats:sub> at the cut-off of 1, the prevalence of contralateral suppression was 6 and 45%, respectively. Using ROC curves, the ACL<\/jats:sub>\/AP<\/jats:sub> ratio is associated with clinical cure at 3 and 12 months and biochemical cure at 12 months. (A\/C)CL<\/jats:sub>\/(A\/C)P<\/jats:sub> is associated with biochemical cure only. The cut-offs for ACL<\/jats:sub>\/AP<\/jats:sub> offering the best sensitivity (Se) and specificity (Sp) for clinical and biochemical cures at 12 months are 2.15 (Se: 63% and Sp: 71%) and 6.15 (Se: 84% and Sp: 77%), respectively. Basal LI and post-ACTH LI are associated with clinical cure but only the post-ACTH LI is associated with biochemical cure.<\/jats:p>\n<\/jats:sec>\n\nConclusions:<\/jats:italic><\/jats:title>\nIn lateralized PA, basal contralateral suppression defined by ACL<\/jats:sub>\/AP<\/jats:sub> is rare and incomplete compared to the (A\/C)CL<\/jats:sub>\/(A\/C)P<\/jats:sub> ratio and is associated with clinical and biochemical postoperative outcome, but with modest accuracy.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-20-0254","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T17:03:20Z","timestamp":1594746200000},"page":"399-409","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":24,"title":["Basal contralateral aldosterone suppression is rare in lateralized primary aldosteronism"],"prefix":"10.1093","volume":"183","author":[{"given":"Marie-Jos\u00e9e","family":"Desrochers","sequence":"first","affiliation":[{"name":"1Division of Endocrinology, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"St-Jean","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"El Ghorayeb","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Bourdeau","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benny","family":"So","sequence":"additional","affiliation":[{"name":"4Department of Radiology, University of Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Therasse","sequence":"additional","affiliation":[{"name":"2Department of Radiology, Centre de Recherche du Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Kline","sequence":"additional","affiliation":[{"name":"3Division of Endocrinology, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Lacroix","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/183\/4\/EJE-20-0254.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/183\/4\/EJE-20-0254.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:14:46Z","timestamp":1676391286000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/183\/4\/399\/6653757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-0254","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}