{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:19:01Z","timestamp":1780647541971,"version":"3.54.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n<jats:title><jats:italic>Objective:<\/jats:italic><\/jats:title>\n<jats:p>Turner syndrome (TS) is a rare disorder affecting 1\/2500 female newborn. Aortic dilatation (AD) and aortic dissection represent a major concern in TS. The aims of our study were to describe the aortic root growth, potential aortic dilatation (AD) risk factors and cardiovascular outcomes in a cohort of patients with TS.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title><jats:italic>Methods:<\/jats:italic><\/jats:title>\n<jats:p>Among 204 adult patients included, 197 were studied using a standardized 1.5 Tesla MRI protocol. AD was defined as an aortic diameter \u226520 mm\/m<jats:sup>2<\/jats:sup> at the Valsalva sinuses and\/or at the ascending aorta, when indexed to body surface area.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title><jats:italic>Results:<\/jats:italic><\/jats:title>\n<jats:p>At baseline, AD was present in 81\/197 (41.1%) and 32\/197 (16.2%) of patients, at the levels of Valsalva and ascending aorta, respectively. The aortic Valsalva diameter was larger in patients treated for thyroiditis (<jats:italic>P<\/jats:italic> &lt; 0.001). Potential risk factors of AD were aging (<jats:italic>P<\/jats:italic> &lt; 0.001) and the presence of bicuspid aortic valve (BAV) (<jats:italic>P<\/jats:italic>\u2009=\u20090.002). The hazard ratio (HR) of AD occurrence in the presence of BAV was 2.2 (95% CI: 1.33\u20133.71). After a median follow-up period of 5.1 years (<jats:italic>n<\/jats:italic>\u2009=\u2009143), AD was present in 58\/143 (40.6%) and 25\/143 (17.5%) of patients at the levels of Valsalva and ascending aorta, respectively. The median aortic growth of the Valsalva sinuses remained stable. At the ascending aorta, it increased by 0.14 \u00b1 0.61 mm\/year. Only one aortic-related death was observed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title><jats:italic>Conclusion:<\/jats:italic><\/jats:title>\n<jats:p>AD is common in adult patients with TS. However, our results are rather reassuring, as the median aortic diameters remained stable after 5.1 years and few aortic events were observed.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-20-0284","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T11:13:21Z","timestamp":1598008401000},"page":"463-470","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":16,"title":["Prevalence and progression of aortic dilatation in adult patients with Turner syndrome: a cohort study"],"prefix":"10.1093","volume":"183","author":[{"given":"Bruno","family":"Donadille","sequence":"first","affiliation":[{"name":"1Endocrinology Department, Saint Antoine Hospital and Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"},{"name":"2Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance et du D\u00e9veloppement (CRMERCD), Fili\u00e8re FIRENDO, Endo-ERN id 739527, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Tuffet","sequence":"additional","affiliation":[{"name":"3Clinical Research Unit (URC-EST), Saint Antoine Hospital and Functional Unit of Pharmacology, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Cholet","sequence":"additional","affiliation":[{"name":"4Radiology Department, Saint Antoine Hospital, Assistance Publique-H\u00f4pitaux de Paris, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Nedelcu","sequence":"additional","affiliation":[{"name":"1Endocrinology Department, Saint Antoine Hospital and Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"},{"name":"2Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance et du D\u00e9veloppement (CRMERCD), Fili\u00e8re FIRENDO, Endo-ERN id 739527, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Bourcigaux","sequence":"additional","affiliation":[{"name":"1Endocrinology Department, Saint Antoine Hospital and Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"},{"name":"2Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance et du D\u00e9veloppement (CRMERCD), Fili\u00e8re FIRENDO, Endo-ERN id 739527, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Iserin","sequence":"additional","affiliation":[{"name":"5Congenital Heart Disease Unit, Cardiology Department, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Monnier-Cholley","sequence":"additional","affiliation":[{"name":"4Radiology Department, Saint Antoine Hospital, Assistance Publique-H\u00f4pitaux de Paris, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rousseau","sequence":"additional","affiliation":[{"name":"3Clinical Research Unit (URC-EST), Saint Antoine Hospital and Functional Unit of Pharmacology, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Christin-Maitre","sequence":"additional","affiliation":[{"name":"1Endocrinology Department, Saint Antoine Hospital and Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"},{"name":"2Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance et du D\u00e9veloppement (CRMERCD), Fili\u00e8re FIRENDO, Endo-ERN id 739527, Paris, France"},{"name":"6Inserm Unit UMR-S933, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/183\/4\/EJE-20-0284.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/183\/4\/EJE-20-0284.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:14:52Z","timestamp":1676391292000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/183\/4\/463\/6653756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-0284","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}