{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:31Z","timestamp":1787022811921,"version":"build-2736575974"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,9]]},"abstract":"\n \n Objective:<\/jats:italic>\n <\/jats:title>\n The association between chronic autoimmune thyroiditis (CAT) and differentiated thyroid cancer (DTC) remains controversial. The incidence of DTC increases when screening procedures are implemented, as typically occurs in CAT patients being routinely submitted to thyroid ultrasound (US). The aim of this study was to longitudinally evaluate the long-term development of DTC in patients with CAT.<\/jats:p>\n <\/jats:sec>\n \n \n Design and methods:<\/jats:italic>\n <\/jats:title>\n \n A retrospective longitudinal cohort study was designed. For the study, 510 patients with chronic autoimmune thyroiditis (CAT) with a 10-year follow-up were enrolled. Patients were divided in two groups according to the presence (CAT+ NOD+;\n n<\/jats:italic>\n \u2009=\u2009115) or absence (CAT+ NOD\u2212;\n n<\/jats:italic>\n \u2009=\u2009395) of co-existent nodules at diagnosis. The main outcome measures were appearance of new thyroid-nodules and development of DTC during follow-up.\n <\/jats:p>\n <\/jats:sec>\n \n \n Results:<\/jats:italic>\n <\/jats:title>\n \n During a 10-year median follow-up period, new thyroid-nodules were detected in 34\/115 (29.5%) patients in the CAT+ NOD+ group and in 41\/395 (10.3%) in the CAT+ NOD\u2212 group (\n P<\/jats:italic>\n \u2009<\u20090.001). Logistic regression analysis showed that thyroid-volume at diagnosis and belonging to the CAT+ NOD+ group significantly predicted the appearance of a new thyroid nodule during follow-up, independently of baseline age and sex. Among the 75 patients experiencing the appearance of a new nodule, 27 (39%) met the criteria for fine-needle-aspiration-cytology (FNAC). A benign cytological diagnosis was rendered in all cases.\n <\/jats:p>\n <\/jats:sec>\n \n \n Conclusions:<\/jats:italic>\n <\/jats:title>\n In our series of CAT patients, the appearance of new thyroid-nodules was frequent, but none of them were found to be malignant. The presence of CAT appears to be associated with a negligible risk of developing clinically overt DTC.<\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/eje-20-0350","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T13:06:00Z","timestamp":1592917560000},"page":"317-323","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":13,"title":["Patients with chronic autoimmune thyroiditis are not at higher risk for developing clinically overt thyroid cancer: a 10-year follow-up study"],"prefix":"10.1093","volume":"183","author":[{"given":"Mario","family":"Rotondi","sequence":"first","affiliation":[{"name":"1Istituti Clinici Scientifici Maugeri IRCCS, Unit of Internal Medicine and Endocrinology, Laboratory for Endocrine Disruptors, Pavia, Italy"},{"name":"2Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Groppelli","sequence":"additional","affiliation":[{"name":"3Unit of Internal Medicine, Medical-Oncologic Department, ASST Lodi, Lodi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Croce","sequence":"additional","affiliation":[{"name":"1Istituti Clinici Scientifici Maugeri IRCCS, Unit of Internal Medicine and Endocrinology, Laboratory for Endocrine Disruptors, Pavia, Italy"},{"name":"2Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy"},{"name":"4PhD course in Experimental Medicine, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Latrofa","sequence":"additional","affiliation":[{"name":"5Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ancona","sequence":"additional","affiliation":[{"name":"2Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Coperchini","sequence":"additional","affiliation":[{"name":"1Istituti Clinici Scientifici Maugeri IRCCS, Unit of Internal Medicine and Endocrinology, Laboratory for Endocrine Disruptors, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pasquali","sequence":"additional","affiliation":[{"name":"6Department Advanced Medical and Surgical Science, A.O.U. Vanvitelli, University of Campania \u2018Luigi Vanvitelli\u2019, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Cappelli","sequence":"additional","affiliation":[{"name":"7Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Fugazza","sequence":"additional","affiliation":[{"name":"8Digestive Endoscopy Unit, Department of Gastroenterology, Humanitas Research Hospital, Rozzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Guazzoni","sequence":"additional","affiliation":[{"name":"3Unit of Internal Medicine, Medical-Oncologic Department, ASST Lodi, Lodi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Radetti","sequence":"additional","affiliation":[{"name":"9Marienklinik, Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Chiovato","sequence":"additional","affiliation":[{"name":"1Istituti Clinici Scientifici Maugeri IRCCS, Unit of Internal Medicine and Endocrinology, Laboratory for Endocrine Disruptors, Pavia, Italy"},{"name":"2Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/183\/3\/EJE-20-0350.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/183\/3\/EJE-20-0350.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:14:56Z","timestamp":1676373296000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/183\/3\/317\/6653748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-0350","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}