{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:35:18Z","timestamp":1790753718516,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10]]},"abstract":"\nObjective:<\/jats:italic><\/jats:title>\nGrowth hormone (GH) and insulin-like growth factor 1 (IGF-1) excess results in both reversible and irreversible musculoskeletal damage, including increased vertebral fracture (VF) risk. The prevalence of VFs is approximately 60% in controlled acromegaly patients, and these VFs can progress in time. We aimed to identify the course of VFs in a cohort of acromegaly patients in long-term remission and their associated risk factors during prolonged follow-up.<\/jats:p>\n<\/jats:sec>\n\nMethods:<\/jats:italic><\/jats:title>\nThirty-one patients with acromegaly (49% female, median age 60 years (IQR 53\u201366)), who were in remission for \u22652 years, were included in this longitudinal, prospective, follow-up study. Spine radiographs of vertebrae Th4 to L4 were assessed for VFs using the Genant score, at baseline, after 2.6 years and 9.1 years. Progression was defined as either a new fracture or a \u22651-point increase in Genant score.<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:italic><\/jats:title>\nThe prevalence of VF at baseline was 87% (27\/31 patients). Progression of VFs was observed in eleven patients (35.5%) during the 9.1-year follow-up period, with a total incidence rate of 65.5 per 1000 person years (males 59.8 per 1000 person years vs females 71.6 per 1000 person years). Patients treated with surgery or radiotherapy had a higher risk of VF progression in this cohort (P<\/jats:italic>\u2009=\u20090.030).<\/jats:p>\n<\/jats:sec>\n\nConclusions:<\/jats:italic><\/jats:title>\nIn this cohort of long-term, well-controlled acromegalic patients, the prevalence and progression of VFs was high, showing that the deleterious effects of GH and IGF-1 excess on bone persist despite achievement of longstanding remission.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-20-0415","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T16:39:47Z","timestamp":1595263187000},"page":"427-437","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":41,"title":["Progression of vertebral fractures in long-term controlled acromegaly: a 9-year follow-up study"],"prefix":"10.1093","volume":"183","author":[{"given":"I C M","family":"Pelsma","sequence":"first","affiliation":[{"name":"1Department of Medicine, Division of Endocrinology, and Center for Endocrine Tumors Leiden, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N R","family":"Biermasz","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Division of Endocrinology, and Center for Endocrine Tumors Leiden, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Pereira","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Division of Endocrinology, and Center for Endocrine Tumors Leiden, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W R","family":"van Furth","sequence":"additional","affiliation":[{"name":"2Department of Neurosurgery, and Center for Endocrine Tumors Leiden, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N M","family":"Appelman-Dijkstra","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Division of Endocrinology, and Center for Endocrine Tumors Leiden, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kloppenburg","sequence":"additional","affiliation":[{"name":"3Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands"},{"name":"4Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H M","family":"Kroon","sequence":"additional","affiliation":[{"name":"5Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K M J A","family":"Claessen","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Division of Endocrinology, and Center for Endocrine Tumors Leiden, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/183\/4\/EJE-20-0415.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/183\/4\/EJE-20-0415.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:15:02Z","timestamp":1676391302000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/183\/4\/427\/6653685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-0415","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}