{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:44:28Z","timestamp":1790484268440,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title> \n<jats:p>Somatostatin receptor ligands (SRL) are useful to control central hyperthyroidism in patients with thyrotropin-secreting pituitary adenoma (TSH pituitary adenoma). The aim of this study was to describe the frequency of thyrotropin deficiency (TSH deficiency) in patients with TSH pituitary adenoma treated by SRL.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design<\/jats:title>\n<jats:p>Retrospective study.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Patients with central hyperthyroidism due to TSH pituitary adenoma treated by short or long-acting SRL were retrospectively included. TSH deficiency was defined by a low FT4 associated with non-elevated TSH concentrations during SRL therapy. We analysed the frequency of TSH deficiency and the characteristics of patients with or without TSH deficiency.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Forty-six patients were included. SRL were used as the first-line therapy in 21 of 46 patients (46%). Central hyperthyroidism was controlled in 36 of 46 patients (78%). TSH deficiency appeared in 7 of 46 patients (15%) after a median time of 4 weeks (4\u20137) and for a median duration of 3 months (2.5\u20133). The TSH deficiency occurred after one to three injections of long-acting SRL used as first-line therapy in 6\/7 cases. There were no differences in terms of clinical and hormonal features, size of adenomas or doses of SRL between patients with or without TSH deficiency.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>SRL can induce TSH deficiency in patients with central hyperthyroidism due to TSH pituitary adenoma. Thyrotropic function should be assessed before the first three injections of SRL in order to track TSH deficiency and reduce the frequency of injections when control of thyrotoxicosis rather than tumour reduction is the aim of the treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-20-0484","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T16:15:40Z","timestamp":1602000940000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":7,"title":["Somatostatin receptor ligands induce TSH deficiency in thyrotropin-secreting pituitary adenoma"],"prefix":"10.1093","volume":"184","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Illouz","sequence":"first","affiliation":[{"name":"1Centre de R\u00e9f\u00e9rence des Maladies Rares de la Thyro\u00efde et des R\u00e9cepteurs Hormonaux TRH, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse HYPO, Service d\u2019Endocrinologie, Diab\u00e9tologie et Nutrition, CHU d\u2019Angers, Angers Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chanson","sequence":"additional","affiliation":[{"name":"2Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires Paris-Sud, H\u00f4pital de Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse HYPO, Le Kremlin-Bic\u00eatre, France"},{"name":"3UMR S-1185, Fac Med Paris-Sud, Universit\u00e9 Paris-Saclay, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Sonnet","sequence":"additional","affiliation":[{"name":"4Service d\u2019Endocrinologie Diab\u00e9tologie Nutrition, CHU de BREST, BREST Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Brue","sequence":"additional","affiliation":[{"name":"5Assistance Publique-H\u00f4pitaux de Marseille (AP-HM), Service d\u2019Endocrinologie, H\u00f4pital de la Conception, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse HYPO, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Ferriere","sequence":"additional","affiliation":[{"name":"6Service d\u2019Endocrinologie, Diab\u00e9tologie et Nutrition, H\u00f4pital Haut L\u00e9v\u00eaque, CHU Bordeaux, Pessac, France"},{"name":"7INSERM, Neurocentre Magendie, Physiopathologie de la Plasticit\u00e9 Neuronale, Bordeaux, France"},{"name":"8Universit\u00e9 de Bordeaux, Neurocentre Magendie, Physiopathologie de la Plasticit\u00e9 Neuronale, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Raffin Sanson","sequence":"additional","affiliation":[{"name":"9Service d\u2019Endocrinologie et Nutrition, CHU Ambroise-Par\u00e9, AP-HP, Boulogne-Billancourt, France"},{"name":"10Inserm U1173, Universit\u00e9 Versailles-Saint-Quentin, Montigny-Le-Bretonneux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Vantyghem","sequence":"additional","affiliation":[{"name":"11Service d\u2019Endocrinologie et M\u00e9tabolisme, CHU Lille, Lille, France"},{"name":"12UMR 1190 Translational Research in Diabetes INSERM, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rald","family":"Raverot","sequence":"additional","affiliation":[{"name":"13Universit\u00e9 de Lyon, Lyon1, Lyon, France"},{"name":"14Inserm U1052, CNRS UMR5286, Cancer Research Center of Lyon, Lyon, France"},{"name":"15F\u00e9d\u00e9ration d\u2019Endocrinologie, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Munier","sequence":"additional","affiliation":[{"name":"16Centre de R\u00e9f\u00e9rence des Maladies rares de la Thyro\u00efde et des R\u00e9cepteurs Hormonaux, Institut MITOVASC, Universit\u00e9 d\u2019Angers, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Rodien","sequence":"additional","affiliation":[{"name":"17Centre de R\u00e9f\u00e9rence des Maladies Rares de la Thyro\u00efde et des R\u00e9cepteurs Hormonaux TRH, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse HYPO Service d\u2019Endocrinologie, Diab\u00e9tologie et Nutrition, CHU d\u2019Angers, Institut MITOVASC, Universit\u00e9 d\u2019Angers, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Briet","sequence":"additional","affiliation":[{"name":"18Centre de R\u00e9f\u00e9rence des Maladies Rares de la Thyro\u00efde et des R\u00e9cepteurs Hormonaux TRH Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse HYPO Service d\u2019Endocrinologie, Diab\u00e9tologie et Nutrition, CHU d\u2019Angers, Institut MITOVASC, Universit\u00e9 d\u2019Angers, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of 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