{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:04:34Z","timestamp":1792033474579,"version":"4.4.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the metformin effect on the risk of osteoporosis (OS) and\/or vertebral fracture (VF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 14 611 pairs of metformin ever and never users matched on propensity score (PS) from Taiwan\u2019s National Health Insurance database. All patients had new-onset type 2 diabetes mellitus (T2DM) during 1999\u20132005 and were free from OS and\/or any fracture at the start of follow-up on January 1, 2006. They were followed up until December 31, 2011 for the incidence of OS\/VF. Cox regression incorporated with the inverse probability of treatment weighting using PS was used in the main analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>New-onset OS\/VF was diagnosed in 1757 never users (median follow-up 5.0 years) and 1143 ever users (median follow-up 5.3 years). The respective incidence rates were 2870.97 and 1713.20 per 100 000 person-years. Two-thirds of the incident cases had OS without VF and the other third had VF. In main analyses, the hazard ratio for ever vs never users was 0.592 (95% CI: 0.550\u20130.638). In either sex, a dose\u2013response pattern was noted and metformin therapy &gt; 2 years was consistently associated with a lower risk. The protective effect attenuated with increasing age but remained significant in patients aged \u2265 80 years. In sensitivity analyses, metformin significantly reduced the risk of both OS and VF (with or without a prior OS) by 30\u201340%. Additional analyses showed a null association for other antidiabetic drugs, but significant interactions between metformin and insulin, sulfonylurea and pioglitazone, respectively, were noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Metformin use is associated with a lower risk of OS\/VF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eje-20-0507","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T10:16:21Z","timestamp":1606990581000},"page":"299-310","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":48,"title":["Metformin use is associated with a lower risk of osteoporosis\/vertebral fracture in Taiwanese patients with type 2 diabetes mellitus"],"prefix":"10.1093","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9545-7123","authenticated-orcid":true,"given":"Chin-Hsiao","family":"Tseng","sequence":"first","affiliation":[{"name":"1Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan"},{"name":"2Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan"},{"name":"3Division of Environmental Health and Occupational Medicine of the National Health Research Institutes, Zhunan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/184\/2\/EJE-20-0507.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/184\/2\/EJE-20-0507.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:15:08Z","timestamp":1676373308000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/184\/2\/299\/6653810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-0507","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}