{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:18:25Z","timestamp":1783487905259,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>Endocrine Society guidelines recommend adrenal venous sampling (AVS) in primary aldosteronism (PA) if adrenalectomy is considered. We tested whether functional imaging of adrenal cortex with <jats:sup>11<\/jats:sup>C-metomidate (<jats:sup>11<\/jats:sup>C-MTO) could offer a noninvasive alternative to AVS in the subtype classification of PA.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design<\/jats:title>\n<jats:p>We prospectively recruited 58 patients with confirmed PA who were eligible for adrenal surgery.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Subjects underwent AVS and <jats:sup>11<\/jats:sup>C-MTO-PET without dexamethasone pretreatment in random order. The lateralization of <jats:sup>11<\/jats:sup>C-MTO-PET and adrenal CT were compared with AVS in all subjects and in a prespecified adrenalectomy subgroup in which the diagnosis was confirmed with immunohistochemical staining for CYP11B2.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>In the whole study population, the concordance of AVS and <jats:sup>11<\/jats:sup>C-MTO-PET was 51% and did not differ from that of AVS and adrenal CT (53%).<jats:italic\/> The concordance of AVS and <jats:sup>11<\/jats:sup>C-MTO-PET was 55% in unilateral and 44% in bilateral PA. In receiver operating characteristics analysis, the maximum standardized uptake value ratio of 1.16 in <jats:sup>11<\/jats:sup>C-MTO-PET had an AUC of 0.507 (<jats:italic>P\u2009=\u2009<\/jats:italic>n.s.) to predict allocation to adrenalectomy or medical therapy with sensitivity of 55% and specificity of 44%. In the prespecified adrenalectomy subgroup, AVS and <jats:sup>11<\/jats:sup>C-MTO-PET were concordant in 10 of 19 subjects with CYP11B2-positive adenoma and in 6 of 10 with CYP11B2-positivity without an adenoma.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The concordance of <jats:sup>11<\/jats:sup>C-MTO-PET with AVS was clinically suboptimal, and did not outperform adrenal CT. In a subgroup with CYP11B2-positive adenoma, <jats:sup>11<\/jats:sup>C-MTO-PET identified 53% of cases. <jats:sup>11<\/jats:sup>C-MTO-PET appeared to be inferior to AVS for subtype classification of PA.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-20-0532","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T15:00:55Z","timestamp":1599058855000},"page":"539-550","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":53,"title":["Functional imaging with 11C-metomidate PET for subtype diagnosis in primary aldosteronism"],"prefix":"10.1093","volume":"183","author":[{"given":"Minna","family":"Soinio","sequence":"first","affiliation":[{"name":"1Department of Endocrinology, Turku University Hospital, Turku, Finland"},{"name":"2Turku PET Centre, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Kaarina","family":"Luukkonen","sequence":"additional","affiliation":[{"name":"3Department of Internal Medicine and Tampere University, Tampere University Hospital, Faculty of Medicine and Health Technology, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Sepp\u00e4nen","sequence":"additional","affiliation":[{"name":"2Turku PET Centre, University of Turku, Turku, Finland"},{"name":"4Department of clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka","family":"Kemppainen","sequence":"additional","affiliation":[{"name":"2Turku PET Centre, University of Turku, Turku, Finland"},{"name":"4Department of clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Sepp\u00e4nen","sequence":"additional","affiliation":[{"name":"5Centre for Vascular Surgery and Interventional Radiology, Tampere University Hospital, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha-Pekka","family":"Pienim\u00e4ki","sequence":"additional","affiliation":[{"name":"5Centre for Vascular Surgery and Interventional Radiology, Tampere University Hospital, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Leijon","sequence":"additional","affiliation":[{"name":"6Department of Pathology, University of Helsinki and HUSLAB, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiina","family":"Vesterinen","sequence":"additional","affiliation":[{"name":"6Department of Pathology, University of Helsinki and HUSLAB, Helsinki University Hospital, Helsinki, Finland"},{"name":"7Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Arola","sequence":"additional","affiliation":[{"name":"6Department of Pathology, University of Helsinki and HUSLAB, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eila","family":"Lantto","sequence":"additional","affiliation":[{"name":"8Medical Imaging Center, Radiology, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semi","family":"Helin","sequence":"additional","affiliation":[{"name":"2Turku PET Centre, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"Tikkanen","sequence":"additional","affiliation":[{"name":"9Abdominal Center, Nephrology, University of Helsinki, and Helsinki University Hospital, and Minerva Institute for Medical Research, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saara","family":"Metso","sequence":"additional","affiliation":[{"name":"3Department of Internal Medicine and Tampere University, Tampere University Hospital, Faculty of Medicine and Health Technology, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Mirtti","sequence":"additional","affiliation":[{"name":"6Department of Pathology, University of Helsinki and HUSLAB, Helsinki University Hospital, Helsinki, Finland"},{"name":"10Research Program in Systems Oncology (ONCOSYS), University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"Heiskanen","sequence":"additional","affiliation":[{"name":"11Endocrine Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Norvio","sequence":"additional","affiliation":[{"name":"12Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirja","family":"Tiikkainen","sequence":"additional","affiliation":[{"name":"12Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuula","family":"Tikkanen","sequence":"additional","affiliation":[{"name":"13Internal Medicine Outpatient Clinics, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sane","sequence":"additional","affiliation":[{"name":"12Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"V\u00e4lim\u00e4ki","sequence":"additional","affiliation":[{"name":"12Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso E","family":"Gomez-Sanchez","sequence":"additional","affiliation":[{"name":"14Department of Pharmacology, G.V. (Sonny) Montgomery VA Medical Center, University of Mississippi Medical Center, Jackson, Mississippi, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"P\u00f6rsti","sequence":"additional","affiliation":[{"name":"3Department of Internal Medicine and Tampere University, Tampere University Hospital, Faculty of Medicine and Health Technology, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirjo","family":"Nuutila","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Turku University Hospital, Turku, Finland"},{"name":"2Turku PET Centre, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasi I","family":"Nevalainen","sequence":"additional","affiliation":[{"name":"3Department of Internal Medicine and Tampere University, Tampere University Hospital, Faculty of Medicine and Health Technology, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niina","family":"Matikainen","sequence":"additional","affiliation":[{"name":"12Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"},{"name":"15Research Programs Unit, Clinical and Molecular Medicine, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/183\/6\/EJE-20-0532.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/183\/6\/EJE-20-0532.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:15:10Z","timestamp":1676391310000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/183\/6\/539\/6653781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-0532","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]}}}