{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:53:10Z","timestamp":1791337990037,"version":"4.3.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>We conducted a retrospective study on the long-term effect of mitotane treatment on testicular adrenal rest tumors (TARTs) in five adult patients with classic 21-hydroxylase deficiency. After 60 months of mitotane treatment, a decrease in adrenal steroids was observed in four patients. Testicular ultrasonography showed complete disappearance of TART in two patients, stabilization in two patients and a halving of TART volume in the remaining patient. Sperm count improved notably in two patients who had normal baseline inhibin B levels and small inclusions, thus enabling cryopreservation of the subjects\u2019 semen. Four years of follow-up of these two patients after the withdrawal of mitotane showed no recurrence of TART and persistent normal testicular function. In conclusion, mitotane could be used as a last resort in CAH patients in the cases of azoospermia associated with TARTs but normal inhibin B levels, as it can improve long-term endocrine and exocrine testicular function.<\/jats:p>","DOI":"10.1530\/eje-20-0787","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T22:59:15Z","timestamp":1610492355000},"page":"365-371","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":19,"title":["Effects of mitotane on testicular adrenal rest tumors in congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a retrospective series of five patients"],"prefix":"10.1093","volume":"184","author":[{"given":"Anne","family":"Bachelot","sequence":"first","affiliation":[{"name":"1AP-HP, IE3M, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Department of Endocrinology and Reproductive Medicine and Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance et du D\u00e9veloppement, Paris, France"},{"name":"2Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Lapoirie","sequence":"additional","affiliation":[{"name":"3Department of Endocrinology, Hospices Civils de Lyon, F\u00e9d\u00e9ration d'Endocrinologie, Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Dulon","sequence":"additional","affiliation":[{"name":"1AP-HP, IE3M, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Department of Endocrinology and Reproductive Medicine and Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance et du D\u00e9veloppement, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Leban","sequence":"additional","affiliation":[{"name":"4AP-HP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Department of Hormonal Biochemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00eble","family":"Renard Penna","sequence":"additional","affiliation":[{"name":"2Sorbonne Universit\u00e9, Paris, France"},{"name":"5AP-HP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Department of Radiology, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Touraine","sequence":"additional","affiliation":[{"name":"1AP-HP, IE3M, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Department of Endocrinology and Reproductive Medicine and Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance et du D\u00e9veloppement, Paris, France"},{"name":"2Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/184\/3\/EJE-20-0787.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/184\/3\/EJE-20-0787.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:15:28Z","timestamp":1676391328000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/184\/3\/365\/6653799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-0787","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}