{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:20:43Z","timestamp":1785151243723,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"\nObjective<\/jats:title>\nDue to the rarity of Cushing\u2019s syndrome (CS) in children and adolescents, data are scarce about BMI during active disease and following remission. Therefore, our aim was to analyze BMI after long-term remission and determine predictive factors for promptly identifying patients at risk of being overweight or obese after remission for CS.<\/jats:p>\n<\/jats:sec>\n\nDesign<\/jats:title>\nRetrospective cohort study.<\/jats:p>\n<\/jats:sec>\n\nPatients<\/jats:title>\n73 patients: 58 (79.4%) had Cushing disease, 40 males (58%), median age of 12 years (IQR: 9\u201315). The mean follow-up time was 22.4 \u00b1 18.2 months (range: 4\u201398).<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nMain outcome measures: BMI, lipid profile, blood pressure, HOMA-IR.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nAt diagnosis, only eight (11%) patients had a normal weight. Although the BMI z-score at the last follow-up improved (2.0 \u00b1 0.7 to 1.0 \u00b1 1.2, P<\/jats:italic> < 0.001), 44% remained overweight or obese after 2 years of remission according to the Kaplan-Meier curves. The BMI z-scores at the last follow-up correlated only with HOMA-IR levels (r: 0.49, P<\/jats:italic> = 0.027). We found two independent factors related to reaching a normal weight: BMI z-score at diagnosis (HR: 0.156, 95% CI: 0.038\u20130.644; P<\/jats:italic> = 0.01) and BMI z-score change at 6 \u00b1 2 months (HR: 2.980, 95% CI:1.473\u20136.028; P<\/jats:italic> = 0.002), which had high accuracy when a cut-off of 0.5 was used for ROC analysis (AUC\u2009=\u20090.828 (0.67\u20130.97); P<\/jats:italic> < 0.001).<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nChildren and adolescents with CS have a high risk of being overweight or obese after successful treatment for their disease. At risk patients can be identified quickly based on their baseline BMI and initial weight loss after surgery. Efforts should focus on adopting healthy diet and lifestyle in the immediate postoperative period.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-20-0848","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T14:59:43Z","timestamp":1603465183000},"page":"179-187","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":4,"title":["Pediatric Cushing\u2019s syndrome: greater risk of being overweight or obese after long-term remission and its predictive factors"],"prefix":"10.1093","volume":"184","author":[{"given":"Nuria","family":"Vald\u00e9s","sequence":"first","affiliation":[{"name":"1Section on Endocrinology and Genetics, Developmental Endocrinology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA"},{"name":"2Section on Endocrinology and Nutrition, Hospital Universitario de Cabue\u00f1es, Gij\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Tirosh","sequence":"additional","affiliation":[{"name":"1Section on Endocrinology and Genetics, Developmental Endocrinology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA"},{"name":"3Neuroendocrine Tumors Service, Division of Endocrinology, Metabolism and Diabetes, Chaim Sheba Medical Center, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meg","family":"Keil","sequence":"additional","affiliation":[{"name":"1Section on Endocrinology and Genetics, Developmental Endocrinology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine A","family":"Stratakis","sequence":"additional","affiliation":[{"name":"1Section on Endocrinology and Genetics, Developmental Endocrinology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Lodish","sequence":"additional","affiliation":[{"name":"1Section on Endocrinology and Genetics, Developmental Endocrinology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA"},{"name":"4University of California, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/184\/1\/EJE-20-0848.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/184\/1\/EJE-20-0848.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:15:30Z","timestamp":1676391330000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/184\/1\/179\/6653790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-0848","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}