{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:33Z","timestamp":1787022813549,"version":"build-2736575974"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2]]},"abstract":"\n Background<\/jats:title>\n Diabetes mellitus is an established risk factor for cardiovascular diseases. Even impaired levels of glucose and insulin might harm organ function prior to diabetes onset. Whether serum glucose or insulin plays a direct role in cardiac dysfunction or lung volume reduction remains unclear. The aim was to investigate the relationship between glucose and insulin with the right ventricle and lung volumes within KORA-MRI FF4 study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n From the KORA-MRI FF4 cohort study 337 subjects (mean age 55.7 \u00b1 9.1 years; 43% women) underwent a whole-body 3T MRI scan. Cardiac parameters derived from a cine-steady-state free precession sequence using cvi42. MRI-based lung volumes derived semi-automatically using an in-house algorithm. Fasting serum glucose, fasting insulin levels, and HOMA index were calculated in all study subjects. Linear regression analyses were performed to assess the relationships between glucose and insulin levels with right ventricle volumes and lung volumes adjusted for age, sex, BMI, and cardiovascular risk factors.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In univariate and multivariate-adjusted models, high serum insulin was inversely associated with end-diastolic volume (\u03b2\u2009=\u2009\u221212.43,\n P<\/jats:italic>\n < 0.001), end-systolic volume (\u03b2\u2009=\u2009\u22127.12,\n P<\/jats:italic>\n < 0.001), stroke volume (\u03b2\u2009=\u2009\u22125.32,\n P<\/jats:italic>\n < 0.001), but not with ejection fraction. The association remained significant after additional adjustment for lung volumes. Similarly, serum insulin was inversely associated with lung volume (\u03b2\u2009=\u2009\u22120.15,\n P<\/jats:italic>\n = 0.04). Sensitivity analysis confirmed results after excluding subjects with known diabetes.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Serum insulin was inversely associated with right ventricle function and lung volumes in subjects from the general population free of cardiovascular disease, suggesting that increased insulin levels may contribute to subclinical cardiopulmonary circulation impairment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/eje-20-1010","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T12:32:14Z","timestamp":1605702734000},"page":"289-298","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":9,"title":["Serum insulin is associated with right ventricle function parameters and lung volumes in subjects free of cardiovascular disease"],"prefix":"10.1093","volume":"184","author":[{"given":"Ricarda von","family":"Kr\u00fcchten","sequence":"first","affiliation":[{"name":"1Department of Diagnostic and Interventional Radiology, Universit\u00e4ts Klinikum Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Lorbeer","sequence":"additional","affiliation":[{"name":"2Department of Radiology, Ludwig-Maximilians-University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Rospleszcz","sequence":"additional","affiliation":[{"name":"3Chair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"4Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Storz","sequence":"additional","affiliation":[{"name":"5Department of Neuroradiology, Universit\u00e4ts Klinikum Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Askani","sequence":"additional","affiliation":[{"name":"1Department of Diagnostic and Interventional Radiology, Universit\u00e4ts Klinikum Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Kulka","sequence":"additional","affiliation":[{"name":"1Department of Diagnostic and Interventional Radiology, Universit\u00e4ts Klinikum Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Rathmann","sequence":"additional","affiliation":[{"name":"6German Diabetes Center, Institute for Biometrics and Epidemiology, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Peters","sequence":"additional","affiliation":[{"name":"3Chair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"4Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"},{"name":"7German Center for Diabetes Research (DZD), partner site Neuherberg, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Karrasch","sequence":"additional","affiliation":[{"name":"4Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"},{"name":"8Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital of Munich, Ludwig-Maximilians-Universit\u00e4t, Munich, Germany"},{"name":"9Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munich\/Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Bamberg","sequence":"additional","affiliation":[{"name":"1Department of Diagnostic and Interventional Radiology, Universit\u00e4ts Klinikum Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Schlett","sequence":"additional","affiliation":[{"name":"1Department of Diagnostic and Interventional Radiology, Universit\u00e4ts Klinikum Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blerim","family":"Mujaj","sequence":"additional","affiliation":[{"name":"1Department of Diagnostic and Interventional Radiology, Universit\u00e4ts Klinikum Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/184\/2\/EJE-20-1010.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/184\/2\/EJE-20-1010.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:15:37Z","timestamp":1676373337000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/184\/2\/289\/6653813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-1010","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}