{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T23:14:10Z","timestamp":1777072450420,"version":"3.51.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n<jats:title>Design<\/jats:title>\n<jats:p>Hypercortisolism during pregnancy is a risk factor for prematurity. Long-term exposure to hypercortisolism may lead to permanent comorbidities, such as hypertension or diabetes, even after remission. Our aim was to determine whether women with a history of Cushing\u2019s disease (and being eu-, hypo- or hypercortisolic at the time of pregnancy) had the same risks of comorbidities, and especially prematurity, during pregnancy.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>It was a retrospective multicentric study focusing on mothers with a history of Cushing\u2019s disease or diagnosed during pregnancy, followed in French tertiary referral centers. We compared the outcomes of pregnancies depending on the cortisolic status at the time of pregnancy.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 60 patients (78 pregnancies including 21 with hypercortisolism, 32 with hypocortisolism and 25 in eucortisolism in 25) were evaluated. The overall rate of preterm birth was 24.3%, with a peak in women diagnosed during pregnancy (62.5%), a high risk in hypercortisolic (33%) and hypocortisolic (19.3%), and a low risk (8%) in eucortisolic women Gestational diabetes and hypertension were observed in 21% and 10.4% of the whole cohort, with a higher risk in hypercortisolic women. Cesarean delivery was performed in 33.7% of the cohort.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Being non-eucortisolic at the time of pregnancy increases the risk of prematurity and comorbidities compared to the general population. Women with a history of Cushing\u2019s disease should thus be carefully monitored during pregnancy. The high rate of cesarean delivery emphasizes the fact that these pregnancies should always be considered at risk.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-20-1224","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T19:28:20Z","timestamp":1611343700000},"page":"469-476","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":9,"title":["Pre-term birth in women exposed to Cushing\u2019s disease: the baby-cush study"],"prefix":"10.1093","volume":"184","author":[{"given":"Clarisse","family":"Hochman","sequence":"first","affiliation":[{"name":"1Service d\u2019Endocrinologie, L\u2019institut du thorax, CHU de Nantes, Nantes, Pays de la Loire, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"Cristante","sequence":"additional","affiliation":[{"name":"2Endocrinologie, Diab\u00e9tologie et Maladies M\u00e9taboliques, CHU de Grenoble, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurore","family":"Geslot","sequence":"additional","affiliation":[{"name":"3Service d\u2019Endocrinologie, H\u00f4pital Larrey, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Salenave","sequence":"additional","affiliation":[{"name":"4Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse and Universit\u00e9 Paris-Saclay, Univ. Paris-Sud, Inserm, Signalisation Hormonale, Physiopathologie Endocrinienne et M\u00e9tabolique, Le Kremlin-Bic\u00eatre, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Sonnet","sequence":"additional","affiliation":[{"name":"5Service d\u2019Endocrinologie-Diab\u00e8te et Maladies M\u00e9taboliques, H\u00f4pital de la Cavale Blanche, CHU de Brest, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Briet","sequence":"additional","affiliation":[{"name":"6Service Endocrinologie, Diab\u00e9tologie et Nutrition, Institut Mitovasc, CHU d\u2019Angers, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Bachelot","sequence":"additional","affiliation":[{"name":"7Service d\u2019Endocrinologie et M\u00e9decine de la Reproduction, IE3M, H\u00f4pital Universitaire Piti\u00e9 Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Chevalier","sequence":"additional","affiliation":[{"name":"8Service d\u2019Endocrinologie, CHU de Nice, Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Gilly","sequence":"additional","affiliation":[{"name":"9Service des Maladies M\u00e9taboliques et Endocriniennes, CHU N\u00eemes, Nimes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Brue","sequence":"additional","affiliation":[{"name":"10Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1251, Marseille Medical Genetics (MMG), Institut Marseille Maladies Rares (MarMaRa), Marseille, France"},{"name":"11Assistance Publique-H\u00f4pitaux de Marseille (AP-HM), Department of Endocrinology, H\u00f4pital de la Conception, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019hypophyse HYPO, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samy","family":"Hadjadj","sequence":"additional","affiliation":[{"name":"1Service d\u2019Endocrinologie, L\u2019institut du thorax, CHU de Nantes, Nantes, Pays de la Loire, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronique","family":"Kerlan","sequence":"additional","affiliation":[{"name":"5Service d\u2019Endocrinologie-Diab\u00e8te et Maladies M\u00e9taboliques, H\u00f4pital de la Cavale Blanche, CHU de Brest, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Chanson","sequence":"additional","affiliation":[{"name":"4Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse and Universit\u00e9 Paris-Saclay, Univ. Paris-Sud, Inserm, Signalisation Hormonale, Physiopathologie Endocrinienne et M\u00e9tabolique, Le Kremlin-Bic\u00eatre, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Vezzosi","sequence":"additional","affiliation":[{"name":"3Service d\u2019Endocrinologie, H\u00f4pital Larrey, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Chabre","sequence":"additional","affiliation":[{"name":"2Endocrinologie, Diab\u00e9tologie et Maladies M\u00e9taboliques, CHU de Grenoble, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1808-8800","authenticated-orcid":true,"given":"Delphine","family":"Drui","sequence":"additional","affiliation":[{"name":"1Service d\u2019Endocrinologie, L\u2019institut du thorax, CHU de Nantes, Nantes, Pays de la Loire, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Castinetti","sequence":"additional","affiliation":[{"name":"10Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1251, Marseille Medical Genetics (MMG), Institut Marseille Maladies Rares (MarMaRa), Marseille, France"},{"name":"11Assistance Publique-H\u00f4pitaux de Marseille (AP-HM), Department of Endocrinology, H\u00f4pital de la Conception, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019hypophyse HYPO, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/184\/3\/EJE-20-1224.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/184\/3\/EJE-20-1224.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:15:53Z","timestamp":1676391353000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/184\/3\/469\/6653834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-1224","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}