{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:56:12Z","timestamp":1793321772088,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Glucocorticoid excess leads to muscle atrophy and weakness in patients with endogenous Cushing\u2019s syndrome. Insulin-like growth factor I (IGF-I) is known to have protective effects on muscle loss. We hypothesized that individual serum IGF-I concentrations might be predictive for long-term myopathy outcome in Cushing\u2019s syndrome.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Patients and methods<\/jats:title>\n<jats:p>In a prospective longitudinal study of 31 patients with florid Cushing\u2019s syndrome, we analyzed IGF-I and IGF binding protein 3 (IGFBP 3) concentrations at the time of diagnosis and following surgical remission over a period of up to 3 years. We assessed muscle strength by grip strength measurements using a hand grip dynamometer and muscle mass by bio-impedance measurements.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Findings<\/jats:title>\n<jats:p>Individual serum IGF-I concentrations in the postoperative phase were strongly predictive of long-term grip strength outcome (r<jats:sub>s<\/jats:sub>\u2009=\u20090.696, <jats:italic>P<\/jats:italic> \u2264 0.001). Also, lower IGF-I concentrations were associated with a lower muscle mass after 3 years (r<jats:sub>s<\/jats:sub>\u2009=\u20090.404, <jats:italic>P<\/jats:italic>\u2009\u2009=\u20090.033). While patients with high IGF-I <jats:sc>s.d.<\/jats:sc> scores (SDS; &gt;1.4) showed an improvement in grip strength within the follow-up period (<jats:italic>P<\/jats:italic>\u2009\u2009=\u20090.009), patients with lower IGF-I SDS (\u2264\u22120.4) had a worse outcome with persisting muscle dysfunction. In contrast, preoperative IGF-I concentrations during the florid phase of Cushing\u2019s syndrome did not predict long-term muscle function outcome (r<jats:sub>s<\/jats:sub>\u2009=\u20090.285, <jats:italic>P<\/jats:italic>\u2009\u2009=\u20090.127).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Lower individual IGF-I concentrations 6 months after curative surgery for Cushing\u2019s syndrome are associated with adverse long-term myopathy outcome and IGF-I might be essential for muscle regeneration in the early phase after correction of hypercortisolism.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-20-1285","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T17:11:19Z","timestamp":1617901879000},"page":"813-821","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":20,"title":["Patients with low IGF-I after curative surgery for Cushing\u2019s syndrome have an adverse long-term outcome of hypercortisolism-induced myopathy"],"prefix":"10.1093","volume":"184","author":[{"given":"Frederick","family":"Vogel","sequence":"first","affiliation":[{"name":"1Medizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Braun","sequence":"additional","affiliation":[{"name":"1Medizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"German","family":"Rubinstein","sequence":"additional","affiliation":[{"name":"1Medizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Zopp","sequence":"additional","affiliation":[{"name":"1Medizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarina","family":"Benedix","sequence":"additional","affiliation":[{"name":"1Medizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Schneider","sequence":"additional","affiliation":[{"name":"1Medizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Ritzel","sequence":"additional","affiliation":[{"name":"1Medizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Schilbach","sequence":"additional","affiliation":[{"name":"1Medizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Schmidmaier","sequence":"additional","affiliation":[{"name":"1Medizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Beuschlein","sequence":"additional","affiliation":[{"name":"1Medizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Bayern, Germany"},{"name":"2Klinik f\u00fcr Endokrinologie, Diabetologie und Klinische Ern\u00e4hrung, Universit\u00e4tsSpital Z\u00fcrich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bidlingmaier","sequence":"additional","affiliation":[{"name":"1Medizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"1Medizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/184\/6\/EJE-20-1285.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/184\/6\/EJE-20-1285.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:15:57Z","timestamp":1676391357000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/184\/6\/813\/6654002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-1285","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,1]]}}}