{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:25:20Z","timestamp":1776205520950,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>While evidence on the interface between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the renin-angiotensin-aldosterone-system (RAAS) is accumulating, clinical data on RAAS peptide alteration among coronavirus disease-19 (COVID-19) patients is missing.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design and methods<\/jats:title>\n<jats:p>In this exploratory study, we prospectively included adult patients (aged \u2265 18 years) admitted between February 26 and April 30, 2020 to a tertiary care hospital in Switzerland. We assessed the association of an underlying SARS-CoV-2 infection and equilibrium serum levels of RAAS peptides in hospitalized COVID-19 patients 1:1 propensity-score matched with patients suffering from SARS-CoV-2-negative respiratory infections. Subgroup analyses involved stratification for taking RAAS inhibitors.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>COVID-19 patients had about 50% lower equilibrium serum RAAS peptide levels as compared with matched controls (angiotensin I: 31.6 vs 66.8 pmol\/L, \u221252.7% (95%CI: \u221268.5% to \u221236.9%); angiotensin II: 37.7 vs 92.5 pmol\/L, \u221259.2% (95%CI: \u221272.1% to \u221246.3%); angiotensin (1\u20135): 3.3 vs 6.6 pmol\/L, \u221249.7% (95%CI: \u221259.2% to \u221240.2%); angiotensin (1\u20137): 4.8 vs 7.6 pmol\/L, \u221264.9% (95%CI: \u221284.5% to \u221245.3%)). While the plasma renin activity was lower in COVID-19 patients (88.6 vs 207.9 pmol\/L, \u221258.5% (95%CI: \u221271.4% to \u221245.6%)), there was no difference of angiotensin-converting enzyme (ACE) and ACE2 plasma activity between the groups. Subgroup analyses revealed a pronounced RAAS peptide profile depression in COVID-19 patients among those not on RAAS inhibitors.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>As compared with SARS-CoV-2-negative patients, we found a downregulated RAAS in presence of a SARS-CoV-2 infection. Whether the lower levels of the protective angiotensin (1\u20135) and (1\u20137) are linked to adverse outcomes in COVID-19 warrants further investigation.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-20-1445","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T17:49:35Z","timestamp":1612460975000},"page":"543-552","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":36,"title":["Renin-angiotensin-aldosterone system peptide profiles in patients with COVID-19"],"prefix":"10.1093","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7549-5648","authenticated-orcid":true,"given":"Alexander","family":"Kutz","sequence":"first","affiliation":[{"name":"1Division of General Internal and Emergency Medicine, Diabetes, and Metabolism"},{"name":"2Division of Endocrinology, Diabetes, and Metabolism"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Conen","sequence":"additional","affiliation":[{"name":"1Division of General Internal and Emergency Medicine, Diabetes, and Metabolism"},{"name":"3Division of Infectious Diseases and Hospital Hygiene, University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Gregoriano","sequence":"additional","affiliation":[{"name":"1Division of General Internal and Emergency Medicine, Diabetes, and Metabolism"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Haubitz","sequence":"additional","affiliation":[{"name":"1Division of General Internal and Emergency Medicine, Diabetes, and Metabolism"},{"name":"3Division of Infectious Diseases and Hospital Hygiene, University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Koch","sequence":"additional","affiliation":[{"name":"1Division of General Internal and Emergency Medicine, Diabetes, and Metabolism"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Domenig","sequence":"additional","affiliation":[{"name":"4Attoquant Diagnostics GmbH, Campus-Vienna-Biocenter, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"5Institute of Laboratory Medicine, Kantonsspital Aarau AG, Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat","family":"Mueller","sequence":"additional","affiliation":[{"name":"1Division of General Internal and Emergency Medicine, Diabetes, and Metabolism"},{"name":"2Division of Endocrinology, Diabetes, and Metabolism"},{"name":"6Faculty of Medicine, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Schuetz","sequence":"additional","affiliation":[{"name":"1Division of General Internal and Emergency Medicine, Diabetes, and Metabolism"},{"name":"2Division of Endocrinology, Diabetes, and Metabolism"},{"name":"6Faculty of Medicine, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/184\/4\/EJE-20-1445.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/184\/4\/EJE-20-1445.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:16:09Z","timestamp":1676391369000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/184\/4\/543\/6653893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-1445","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}