{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:20:57Z","timestamp":1792686057258,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"\n Objective<\/jats:title>\n Treatment options for Graves\u2019 disease (GD) consist of antithyroid drugs (ATD), radioactive iodine (RAI) and total thyroidectomy (TT). Guidelines recommend to discuss these options with patients, taking into account patients\u2019 preferences. This study aims to evaluate and compare patients\u2019 and clinicians\u2019 preferences and the trade-offs made in choosing treatment.<\/jats:p>\n <\/jats:sec>\n \n Design and methods<\/jats:title>\n A discrete choice experiment (DCE) was performed with GD patients with a first diagnosis or recurrence in the previous year, and with clinicians. Participants were offered hypothetical treatment options which differed in type of treatment, rates of remission, severe side effects, permanent voice changes and hypocalcemia. Preference heterogeneity was assessed by latent-class analysis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In this study, 286 (82%) patients and 61 (18%) clinicians participated in the DCE. All treatment characteristics had a significant effect on treatment choice (\n P<\/jats:italic>\n \u2009< 0.05). Remission rate was the most important determinant and explained 37 and 35% of choices in patients and clinicians, respectively. Both patients and clinicians preferred ATD over surgery and RAI. A strong negative preference toward RAI treatment was observed in a subclass of patients, whereas clinicians preferred RAI over surgery.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n For both patients and clinicians, remission rate was the most important determinant of treatment choice and ATD was the most preferred treatment option. Patients had a negative preference toward RAI compared to alternatives, whereas clinicians preferred RAI over surgery. Clinicians should be aware that their personal attitude toward RAI differs from that of their patients. This study on patients\u2019 and clinicians\u2019 preferences can support shared decision making and thereby improve clinical treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/eje-20-1490","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T13:26:55Z","timestamp":1617024415000},"page":"803-812","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":44,"title":["Preferences of patients and clinicians for treatment of Graves\u2019 disease: a discrete choice experiment"],"prefix":"10.1093","volume":"184","author":[{"given":"Caroline M J","family":"van Kinschot","sequence":"first","affiliation":[{"name":"1Department of Internal Medicine, Maasstad Hospital, Rotterdam, the Netherlands"},{"name":"2Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas R","family":"Soekhai","sequence":"additional","affiliation":[{"name":"3 Erasmus Choice Modelling Centre"},{"name":"4Erasmus School of Health Policy & Management, Erasmus University Rotterdam, Rotterdam, the Netherlands"},{"name":"5Department of Public Health, Erasmus Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther W","family":"de Bekker-Grob","sequence":"additional","affiliation":[{"name":"3 Erasmus Choice Modelling Centre"},{"name":"4Erasmus School of Health Policy & Management, Erasmus University Rotterdam, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Edward","family":"Visser","sequence":"additional","affiliation":[{"name":"2Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin P","family":"Peeters","sequence":"additional","affiliation":[{"name":"2Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa M","family":"van Ginhoven","sequence":"additional","affiliation":[{"name":"6Academic Center for Thyroid Diseases, Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"van Noord","sequence":"additional","affiliation":[{"name":"1Department of Internal Medicine, Maasstad Hospital, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/184\/6\/EJE-20-1490.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/184\/6\/EJE-20-1490.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:16:14Z","timestamp":1676373374000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/184\/6\/803\/6654005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1530\/eje-20-1490","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,1]]}}}