{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:56:34Z","timestamp":1779292594720,"version":"3.51.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:sec>\n<jats:title>Aims\/hypothesis<\/jats:title>\n<jats:p>Metabolic effects of intermittent unhealthy lifestyle in young adults are poorly studied. We investigated the gluco-metabolic and hepatic effects of participation in Roskilde Festival (1 week of binge drinking and junk food consumption) in young, healthy males.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Fourteen festival participants (FP) were studied before, during and after 1 week\u2019s participation in Roskilde Festival. Fourteen matched controls (CTRL) who did not participate in Roskilde Festival or change their lifestyle in other ways were investigated along a similar timeline.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The FP group consumed more alcohol compared to their standard living conditions (2.0 \u00b1 3.9 vs 16.3 \u00b1 8.3 units\/day, <jats:italic>P<\/jats:italic>\u2009&lt; 0.001). CTRLs did not change their alcohol consumption. AUC for glucose during OGTT did not change in either group. C-peptide responses increased in the FP group (206 \u00b1 24 vs 236 \u00b1 17 min \u00d7 nmol\/L, <jats:italic>P<\/jats:italic>\u2009= 0.052) and the Matsuda index of insulin sensitivity decreased (6.2 \u00b1 2.4 vs 4.7 \u00b1 1.4, <jats:italic>P<\/jats:italic>\u2009\u2009=\u20090.054). AUC for glucagon during oral glucose tolerance test (OGTT) increased in the FP group (1037 \u00b1 90 vs 1562 \u00b1 195 min \u00d7 pmol\/L, <jats:italic>P<\/jats:italic>\u2009= 0.003) together with fasting fibroblast growth factor 21 (FGF21) (62 \u00b1 30 vs 132 \u00b1 72 pmol\/L, <jats:italic>P<\/jats:italic>\u2009&lt; 0.001), growth differentiation factor 15 (GDF5) (276 \u00b1 78 vs 330 \u00b1 83 pg\/mL, <jats:italic>P<\/jats:italic>\u2009= 0.009) and aspartate aminotransferase (AST) levels (37.6 \u00b1 6.8 vs 42.4 \u00b1 11 U\/L, <jats:italic>P<\/jats:italic>\u2009= 0.043). Four participants (29%) developed ultrasound-detectable steatosis and a mean strain elastography-assessed liver stiffness increased (<jats:italic>P<\/jats:italic>\u2009= 0.026) in the FP group.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions\/Interpretation<\/jats:title>\n<jats:p>Participation in Roskilde Festival did not affect oral glucose tolerance but was associated with a reduction in insulin sensitivity, increases in glucagon, FGF21, GDF15 and AST and lead to increased liver stiffness and, in 29% of the participants, ultrasound-detectable hepatic steatosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-21-0122","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T17:29:29Z","timestamp":1619112569000},"page":"23-32","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":7,"title":["Metabolic effects of 1-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults"],"prefix":"10.1093","volume":"185","author":[{"given":"Mia","family":"Demant","sequence":"first","affiliation":[{"name":"1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malte P","family":"Suppli","sequence":"additional","affiliation":[{"name":"1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Signe","family":"Foghsgaard","sequence":"additional","affiliation":[{"name":"1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise","family":"Gether","sequence":"additional","affiliation":[{"name":"1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus F G","family":"Gr\u00f8ndahl","sequence":"additional","affiliation":[{"name":"1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels B","family":"Dalsgaard","sequence":"additional","affiliation":[{"name":"1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid S","family":"Bergmann","sequence":"additional","affiliation":[{"name":"1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalie R","family":"Lanng","sequence":"additional","affiliation":[{"name":"1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e6rke S","family":"Gasbjerg","sequence":"additional","affiliation":[{"name":"1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"},{"name":"2Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Thomasen","sequence":"additional","affiliation":[{"name":"1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonatan I","family":"Bagger","sequence":"additional","affiliation":[{"name":"1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Strandberg","sequence":"additional","affiliation":[{"name":"4Department of Radiology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merete J","family":"K\u00f8nig","sequence":"additional","affiliation":[{"name":"4Department of Radiology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Gr\u00f8nb\u00e6k","sequence":"additional","affiliation":[{"name":"5Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrik","family":"Becker","sequence":"additional","affiliation":[{"name":"6National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolai J","family":"Wewer Albrechtsen","sequence":"additional","affiliation":[{"name":"2Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"7Department of Clinical biochemistry, Rigshospitalet"},{"name":"8NNF Center for Protein Research, Rigshospitalet"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens J","family":"Holst","sequence":"additional","affiliation":[{"name":"2Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"3Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Knop","sequence":"additional","affiliation":[{"name":"9Department of Public Health, Rigshospitalet"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P","family":"Gillum","sequence":"additional","affiliation":[{"name":"3Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Vilsb\u00f8ll","sequence":"additional","affiliation":[{"name":"1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"},{"name":"10Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"11Steno Diabetes Center Copenhagen, Gentofte, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip K","family":"Knop","sequence":"additional","affiliation":[{"name":"1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"},{"name":"3Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"10Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"11Steno Diabetes Center Copenhagen, Gentofte, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of 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