{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:06:50Z","timestamp":1757455610373,"version":"3.40.5"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:sec>\n<jats:title>Purpose<\/jats:title>\n<jats:p>Thyroid hormones (THs) are important mediators of brown adipose tissue (BAT) differentiation. However, the association of TH concentrations with human BAT is unclear. The present work examines the associations between circulating thyroid-stimulating hormone (TSH) and THs concentrations (i.e. free triiodothyronine, FT3, and free thyroxine, FT4), under thermoneutral (22\u201323\u00b0C) and cold-induced conditions, and BAT volume, <jats:sup>18<\/jats:sup>F-fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F-FDG) uptake and mean radiodensity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A total of 106 young healthy, euthyroid adults (34 men\/72 women; 22.0 \u00b1 2.1 years old; 24.9 \u00b1 4.6 kg\/m<jats:sup>2<\/jats:sup>) participated in this cross-sectional study. BAT volume, <jats:sup>18<\/jats:sup>F-FDG uptake and mean radiodensity were assessed after 2 h of personalized (i.e. contemplating each individual's shivering threshold) cold exposure via positron emission tomography\/computed tomography (PET\/CT) static scanning. TSH and THs levels were determined before (thermoneutral) and 1 h after the cold exposure.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Cold exposure increased circulating FT4 (<jats:italic>P<\/jats:italic>\u2009=\u20090.038) and reduced TSH levels (<jats:italic>P<\/jats:italic> \u2264 0.001). Conversely, the FT3 serum concentration was not modified by cold exposure (<jats:italic>P<\/jats:italic>\u2009=\u20090.435). No associations were found between the TSH and THs thermoneutral (all <jats:italic>P<\/jats:italic> &gt; 0.111) or cold-induced levels (all <jats:italic>P<\/jats:italic> &gt; 0.067) and BAT volume, <jats:sup>18<\/jats:sup>F-FDG uptake and mean radiodensity. These findings were independent of sex and BMI.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Thyroid function is modulated by cold exposure, yet it is not associated with BAT volume or glucose metabolism assessed after 2 h of cold exposure in young healthy, euthyroid adults.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-21-0192","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T18:48:32Z","timestamp":1622573312000},"page":"209-218","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":4,"title":["Thyroid function is not associated with brown adipose tissue volume and 18F-fluorodeoxyglucose uptake in young euthyroid adults"],"prefix":"10.1093","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7960-9681","authenticated-orcid":true,"given":"Elisa","family":"Merchan-Ramirez","sequence":"first","affiliation":[{"name":"1PROFITH \u201cPROmoting FITness and Health through Physical Activity\u201d Research Group, Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sports Science, University of Granada, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4455-2483","authenticated-orcid":true,"given":"Guillermo","family":"Sanchez-Delgado","sequence":"additional","affiliation":[{"name":"1PROFITH \u201cPROmoting FITness and Health through Physical Activity\u201d Research Group, Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sports Science, University of Granada, Granada, Spain"},{"name":"2Pennington Biomedical Research Center, Baton Rouge, Louisiano, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Arrizabalaga-Arriazu","sequence":"additional","affiliation":[{"name":"3Department of Endocrinology, Fundaci\u00f3n Hospital de Jove, Gij\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-1859","authenticated-orcid":true,"given":"Borja","family":"Martinez-Tellez","sequence":"additional","affiliation":[{"name":"1PROFITH \u201cPROmoting FITness and Health through Physical Activity\u201d Research Group, Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sports Science, University of Granada, Granada, Spain"},{"name":"4Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2465-3623","authenticated-orcid":true,"given":"Andrea","family":"Mendez-Gutierrez","sequence":"additional","affiliation":[{"name":"5Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix\u201d Center of Biomedical Research, University of Granada, Granada, Spain"},{"name":"6Instituto de Investigaci\u00f3n Biosanitaria (Ibs. Granada), Granada, Spain"},{"name":"7CIBER Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBEROBN), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9645-3260","authenticated-orcid":true,"given":"Manuel","family":"Mu\u00f1oz-Torres","sequence":"additional","affiliation":[{"name":"6Instituto de Investigaci\u00f3n Biosanitaria (Ibs. Granada), Granada, Spain"},{"name":"8Department of Medicine, University of Granada, Granada, Spain"},{"name":"9CIBERFES, Instituto de Salud Carlos III, Granada, Spain"},{"name":"10Endocrinology and Nutrition Service, University Hospital San Cecilio, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-5030","authenticated-orcid":true,"given":"Jose M","family":"Llamas-Elvira","sequence":"additional","affiliation":[{"name":"6Instituto de Investigaci\u00f3n Biosanitaria (Ibs. Granada), Granada, Spain"},{"name":"11Nuclear Medicine Service, Virgen de las Nieves University Hospital, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7548-7138","authenticated-orcid":true,"given":"Jonatan R","family":"Ruiz","sequence":"additional","affiliation":[{"name":"1PROFITH \u201cPROmoting FITness and Health through Physical Activity\u201d Research Group, Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sports Science, University of Granada, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/185\/2\/EJE-21-0192.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/185\/2\/EJE-21-0192.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:16:27Z","timestamp":1676391387000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/185\/2\/209\/6654297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,1]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/eje-21-0192","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"type":"print","value":"0804-4643"},{"type":"electronic","value":"1479-683X"}],"subject":[],"published":{"date-parts":[[2021,8,1]]}}}