{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:37:14Z","timestamp":1790285834874,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:sec>\n<jats:title>Introduction<\/jats:title>\n<jats:p>Patients with acromegaly show musculoskeletal symptoms which may persist despite disease control. Increased i.m. fat fraction is a known cause of muscle dysfunction in several disorders.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>To assess the degree of fat fraction in thigh muscles of controlled acromegaly patients and its relationship with muscle dysfunction.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>In a cross-sectional study, we included 36 patients with controlled acromegaly and 36 matched controls. We assessed the percentage of fat fraction in each thigh muscle, using MRI 2-point Dixon sequence, and muscle performance and strength using the gait speed, timed up and go, 30-s chair stand, and hand grip strength tests. We evaluated joint symptoms using the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Intramuscular fat fraction was greater in patients than controls (<jats:italic>P<\/jats:italic> &lt; 0.05 for muscle compartments, rectus femoris (RF), vastus intermedius (VI), adductor magnus (AM) and semimembranosus). Patients had slower gait speed and poorer performance on the 30-s chair stand and timed up and go tests than controls (<jats:italic>P<\/jats:italic> &lt; 0.05). The greater fat fraction in the combined anterior\u2013posterior compartment and in each muscle was associated with worse performance on timed up and go (<jats:italic>P<\/jats:italic> &lt; 0.05). The fat fraction in the anterior\u2013posterior compartment predicted performance on timed up and go after adjusting for muscle area, IGF-I and WOMAC functional and pain scores (\u03b2\u2009=\u20090.737 <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Patients with controlled acromegaly have greater thigh i.m. fatty infiltration, which is associated with muscle dysfunction. Futures studies are needed to elucidate the mechanisms underlying this relationship.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-21-0209","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T17:56:20Z","timestamp":1620237380000},"page":"167-177","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":23,"title":["Intramuscular fatty infiltration and physical function in controlled acromegaly"],"prefix":"10.1093","volume":"185","author":[{"given":"Luciana","family":"Martel-Duguech","sequence":"first","affiliation":[{"name":"1IIB-Sant Pau and Department of Endocrinology\/Medicine, Hospital Sant Pau, Barcelona, Spain"},{"name":"2UAB, Bellaterra, Barcelona, Spain"},{"name":"3Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Alonso-P\u00e9rez","sequence":"additional","affiliation":[{"name":"3Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), Barcelona, Spain"},{"name":"4Department of Neurology, Hospital Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Bascu\u00f1ana","sequence":"additional","affiliation":[{"name":"5Rehabilitation Unit, Hospital Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"D\u00edaz-Manera","sequence":"additional","affiliation":[{"name":"3Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), Barcelona, Spain"},{"name":"6John Walton Mucular Dystrophy Research Centre, Newcastle University, International Centre for Life, Newcastle upon Tyne, Newcastle, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Llauger","sequence":"additional","affiliation":[{"name":"7Department of Radiology, Hospital Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Nu\u00f1ez-Peralta","sequence":"additional","affiliation":[{"name":"7Department of Radiology, Hospital Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Montesinos","sequence":"additional","affiliation":[{"name":"8Philips Healthcare, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Webb","sequence":"additional","affiliation":[{"name":"1IIB-Sant Pau and Department of Endocrinology\/Medicine, Hospital Sant Pau, Barcelona, Spain"},{"name":"2UAB, Bellaterra, Barcelona, Spain"},{"name":"3Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Valassi","sequence":"additional","affiliation":[{"name":"1IIB-Sant Pau and Department of Endocrinology\/Medicine, Hospital Sant Pau, Barcelona, Spain"},{"name":"3Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), Barcelona, Spain"},{"name":"9Universitat Internacional de Catalunya (UIC), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/185\/1\/EJE-21-0209.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/185\/1\/EJE-21-0209.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:16:27Z","timestamp":1676391387000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/185\/1\/167\/6654361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/eje-21-0209","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,1]]}}}