{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:44:18Z","timestamp":1790397858695,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>Scoliosis is frequently seen in children with Prader\u2013Willi syndrome (PWS). There is still concern that growth hormone (GH) treatment might increase the risk of onset or progression of scoliosis. Short-term data suggested no adverse effects of GH on scoliosis, but long-term effects of GH treatment on development of scoliosis in PWS are unknown. This study investigated the effects of 8 years of GH treatment on scoliosis in children with PWS.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design<\/jats:title>\n<jats:p>Open-label, prospective cohort study in 103 children with PWS receiving GH for 8 years was analyzed. Prevalence and severity of scoliosis were compared to a group of 23 age-matched GH-untreated children with PWS.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Spine X-rays and DEXA-scans were performed, and Cobb angel was measured by two independent observers.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>After 8 years of GH treatment, at median age of 10.8 years, prevalence of scoliosis was 77.7%. No difference in prevalence or severity of scoliosis was found between GH-treated and age-matched untreated children with PWS (<jats:italic>P<\/jats:italic> = 0.409 and <jats:italic>P<\/jats:italic>\u2009= 0.709, respectively). Height SDS and trunkLBM were significantly higher in GH-treated children. Higher bone mineral density of the lumbar spine was found in children without scoliosis after 8 years of GH. Bone mineral apparent density of lumbar spine (BMAD<jats:sub>LS<\/jats:sub>) SDS was associated with lower Cobb angle (r\u2009=\u2009\u22120.270, <jats:italic>P<\/jats:italic>\u2009= 0.008).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Eight years of GH treatment has no adverse effects on the prevalence and severity of scoliosis in children with PWS until 11 years of age. As BMAD<jats:sub>LS<\/jats:sub> SDS is inversely associated with Cobb angle, it is pivotal to optimize the BMD status in children with PWS.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-21-0211","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T17:28:04Z","timestamp":1619112484000},"page":"47-55","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":24,"title":["Effects of 8 years of growth hormone treatment on scoliosis in children with Prader\u2013Willi syndrome"],"prefix":"10.1093","volume":"185","author":[{"given":"Lionne N","family":"Grootjen","sequence":"first","affiliation":[{"name":"1Dutch Reference Center for Prader-Willi Syndrome, Rotterdam, The Netherlands"},{"name":"2Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"},{"name":"4Dutch Growth Research Foundation, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost P H J","family":"Rutges","sequence":"additional","affiliation":[{"name":"3Department of Orthopaedic Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layla","family":"Damen","sequence":"additional","affiliation":[{"name":"1Dutch Reference Center for Prader-Willi Syndrome, Rotterdam, The Netherlands"},{"name":"2Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"},{"name":"4Dutch Growth Research Foundation, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephany H","family":"Donze","sequence":"additional","affiliation":[{"name":"1Dutch Reference Center for Prader-Willi Syndrome, Rotterdam, The Netherlands"},{"name":"2Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"},{"name":"4Dutch Growth Research Foundation, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia F","family":"Juriaans","sequence":"additional","affiliation":[{"name":"1Dutch Reference Center for Prader-Willi Syndrome, Rotterdam, The Netherlands"},{"name":"2Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"},{"name":"4Dutch Growth Research Foundation, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerthe F","family":"Kerkhof","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita C S","family":"Hokken-Koelega","sequence":"additional","affiliation":[{"name":"1Dutch Reference Center for Prader-Willi Syndrome, Rotterdam, The Netherlands"},{"name":"2Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"},{"name":"4Dutch Growth Research Foundation, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/185\/1\/EJE-21-0211.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/185\/1\/EJE-21-0211.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:16:28Z","timestamp":1676391388000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/185\/1\/47\/6654372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/eje-21-0211","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,1]]}}}