{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:32:37Z","timestamp":1782833557894,"version":"3.54.5"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Microprolactinomas are currently treated with dopamine agonists. Outcome information on microprolactinoma patients treated by surgery is limited. This study reports the first large series of consecutive non-invasive microprolactinoma patients treated by pituitary surgery and evaluates the efficiency and safety of this treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Follow-up of a cohort of consecutive patients treated by surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between January 2008 and October 2020, 114 adult patients with pure microprolactinomas were operated on in a single tertiary expert neurosurgical department, using an endoscopic endonasal transsphenoidal approach. Eligible patients presented with a microprolactinoma with no obvious cavernous invasion on MRI. Prolactin was assayed before and after surgery. Disease-free survival was modeled using Kaplan\u2013Meier representation. A cox regression model was used to predict remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median follow-up was 18.2 months (range: 2.8\u2013155). In this cohort, 14\/114 (12%) patients were not cured by surgery, including ten early surgical failures and four late relapses occurring 37.4 months (33\u201341.8) after surgery. From Kaplan\u2013Meier estimates, 1-year and 5-year disease free survival was 90.9% (95% CI: 85.6\u201396.4%) and 81% (95% CI: 71.2\u201392.1%) respectively. The preoperative prolactinemia was the only significant preoperative predictive factor for remission (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). No severe complication was reported, with no anterior pituitary deficiency after surgery, one diabetes insipidus, and one postoperative cerebrospinal fluid leakage properly treated by muscle plasty.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In well-selected microprolactinoma patients, pituitary surgery performed by an expert neurosurgical team is a valid first-line alternative treatment to dopamine agonists.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eje-21-0293","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T10:22:07Z","timestamp":1633342927000},"page":"783-791","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":44,"title":["Pituitary surgery as alternative to dopamine agonists treatment for microprolactinomas: a cohort study"],"prefix":"10.1093","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0735-8278","authenticated-orcid":true,"given":"Bertrand","family":"Baussart","sequence":"first","affiliation":[{"name":"1Department of Neurosurgery, Foch Hospital, Suresnes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Villa","sequence":"additional","affiliation":[{"name":"2INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR 8104, 75014 Paris, France; Universit\u00e9 Paris Descartes-Universit\u00e9 de Paris, 75006 Paris, France"},{"name":"3Department of Pathological Cytology and Anatomy, Foch Hospital, Suresnes, France"},{"name":"4Department of Endocrinology, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Jouinot","sequence":"additional","affiliation":[{"name":"2INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR 8104, 75014 Paris, France; Universit\u00e9 Paris Descartes-Universit\u00e9 de Paris, 75006 Paris, France"},{"name":"5Institut Curie, INSERM U900, MINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Raffin-Sanson","sequence":"additional","affiliation":[{"name":"6Department of Endocrinology, H\u00f4pital Ambroise Par\u00e9, Assistance Publique-H\u00f4pitaux de Paris, Boulogne Billancourt, France"},{"name":"7UE4340, Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines Montigny-le-Bretonneux, Versailles, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Foubert","sequence":"additional","affiliation":[{"name":"8Department of Endocrinology, Foch Hospital, Suresnes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Cazabat","sequence":"additional","affiliation":[{"name":"6Department of Endocrinology, H\u00f4pital Ambroise Par\u00e9, Assistance Publique-H\u00f4pitaux de Paris, Boulogne Billancourt, France"},{"name":"7UE4340, Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines Montigny-le-Bretonneux, Versailles, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Bernier","sequence":"additional","affiliation":[{"name":"3Department of Pathological Cytology and Anatomy, Foch Hospital, Suresnes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fideline","family":"Bonnet","sequence":"additional","affiliation":[{"name":"2INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR 8104, 75014 Paris, France; Universit\u00e9 Paris Descartes-Universit\u00e9 de Paris, 75006 Paris, France"},{"name":"9Hormonal Biology Laboratory, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Cochin, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Dohan","sequence":"additional","affiliation":[{"name":"10Department of Radiology, H\u00f4pital Cochin, AP-HP, Paris, France"},{"name":"11Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Bertherat","sequence":"additional","affiliation":[{"name":"2INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR 8104, 75014 Paris, France; Universit\u00e9 Paris Descartes-Universit\u00e9 de Paris, 75006 Paris, France"},{"name":"12Department of Endocrinology, Center for Rare Adrenal Diseases, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Cochin, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Assi\u00e9","sequence":"additional","affiliation":[{"name":"2INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR 8104, 75014 Paris, France; Universit\u00e9 Paris Descartes-Universit\u00e9 de Paris, 75006 Paris, France"},{"name":"12Department of Endocrinology, Center for Rare Adrenal Diseases, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Cochin, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Gaillard","sequence":"additional","affiliation":[{"name":"1Department of Neurosurgery, Foch Hospital, Suresnes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/185\/6\/EJE-21-0293.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/185\/6\/EJE-21-0293.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:16:34Z","timestamp":1676373394000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/185\/6\/783\/6654314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1530\/eje-21-0293","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740928333.793589881","asserted-by":"object"}]},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,1]]}}}