{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:49:03Z","timestamp":1790470143037,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:sec>\n<jats:title>Objectives<\/jats:title>\n<jats:p>We aimed to investigate the clinical, biochemical, histological and radiological characteristics as well as the response to somatostatin analogs (SSA) in a large cohort of acromegaly patients with a paradoxical GH response (PR) to oral glucose tolerance test (OGTT).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design<\/jats:title>\n<jats:p>Retrospective study.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Of 110 patients with acromegaly included in our study, 30 (PR+; 27%) had a paradoxical GH increase of more than 25% relative to basal GH levels during OGTT.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>At diagnosis, PR+ patients were older than PR\u2212 patients (52 \u00b1 16 years vs 44 \u00b1 14 years, <jats:italic>P<\/jats:italic>\u2009&lt; 0.05) and had smaller pituitary tumors (40% microadenomas vs 19%, <jats:italic>P<\/jats:italic>\u2009&lt; 0.05), which were less often invasive (17% vs 35%, <jats:italic>P<\/jats:italic>\u2009&lt; 0.05), overall more secreting (insulin-like growth factor-1 (IGF-1)\/tumoral surface: 2.35 ULN\/cm<jats:sup>2<\/jats:sup> (0.28\u20139.06) vs 1.08 (0.17\u20137.87), <jats:italic>P<\/jats:italic>\u2009= 0.011), and more often hypointense on T2-weighted MRI (92% vs 48%, <jats:italic>P<\/jats:italic>\u2009= 0.001). While the rate of remission after surgery was similar in the two groups (69%), a better response to SSA treatment was observed in PR+ patients, either before (IGF-1 reduction of &gt; 50% after 3\u20136 months in 77% vs 49%, <jats:italic>P<\/jats:italic>\u2009= 0.023) or after surgery (normalization of IGF-1 in 100% vs 44%, <jats:italic>P<\/jats:italic>\u2009= 0.011).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Our study demonstrates that in acromegaly, a paradoxical GH increase during OGTT is associated with particular features of somatotroph adenomas and with a better prognosis in terms of response to SSA.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-21-0324","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T12:42:17Z","timestamp":1622810537000},"page":"313-321","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":19,"title":["Characteristics and treatment responsiveness of patients with acromegaly and a paradoxical GH increase to oral glucose load"],"prefix":"10.1093","volume":"185","author":[{"given":"Virginie","family":"Atquet","sequence":"first","affiliation":[{"name":"1Department of Endocrinology and Nutrition, Cliniques Universitaires Saint Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsalia","family":"Alexopoulou","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology and Nutrition, Cliniques Universitaires Saint Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Maiter","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology and Nutrition, Cliniques Universitaires Saint Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/185\/2\/EJE-21-0324.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/185\/2\/EJE-21-0324.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:16:36Z","timestamp":1676391396000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/185\/2\/313\/6654371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,1]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/eje-21-0324","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,1]]}}}