{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:09:05Z","timestamp":1790352545816,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Cortisol measurements are essential for the interpretation of adrenal venous samplings (AVS) in primary aldosteronism (PA). Cortisol cosecretion may influence AVS indices. We aimed to investigate whether cortisol cosecretion affects non-adrenocorticotrophic hormone (ACTH)-stimulated AVS results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Retrospective cohort study at a tertiary referral center.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analyzed 278 PA patients who underwent non-ACTH-stimulated AVS and had undergone at least a 1-mg dexamethasone suppression test (DST). Subsets underwent additional late-night salivary cortisol (LSC) and\/or 24-h urinary free cortisol (UFC) measurements. Patients were studied from 2013 to 2020 with follow-up data of 6 months following adrenalectomy or mineralocorticoid antagonist therapy initiation. We analyzed AVS parameters including adrenal vein aldosterone\/cortisol ratios, selectivity, lateralization (LI) and contralateral suppression indices and post-operative ACTH-stimulation. We classified outcomes according to the primary aldosteronism surgical outcome (PASO) criteria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the patients, 18.9% had a pathological DST result (1.9\u20135 \u00b5g\/dL: n = 44 (15.8%); &amp;gt;5 \u00b5g\/dL: n = 8 (2.9%)). Comparison of AVS results stratified according to the 1-mg DST (\u22641.8 vs &amp;gt;1.8 \u00b5g\/dL: P = 0.499; \u22641.8 vs 1.8 \u2264 5 vs &amp;gt;5 \u00b5g\/dL: P = 0.811) showed no difference. Lateralized cases with post DST serum cortisol values &amp;gt; 5 \u00b5g\/dL had lower LI (\u22641.8 \u00b5g\/dL: 11.11 (5.36; 26.76) vs 1.9\u20135 \u00b5g\/dL: 11.76 (4.9; 31.88) vs &amp;gt;5 \u00b5g\/dL: 2.58 (1.67; 3.3); P = 0.008). PASO outcome was not different according to cortisol cosecretion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Marked cortisol cosecretion has the potential to influence non-ACTH-stimulated AVS results. While this could result in falsely classified lateralized cases as bilateral, further analysis of substitutes for cortisol are required to unmask effects on clinical outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1530\/eje-21-0541","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T18:22:22Z","timestamp":1662574942000},"page":"637-650","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":27,"title":["Influence of cortisol cosecretion on non-ACTH-stimulated adrenal venous sampling in primary aldosteronism: a retrospective cohort study"],"prefix":"10.1093","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7086-0562","authenticated-orcid":false,"given":"Daniel Alexander","family":"Heinrich","sequence":"first","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum , Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4028-1671","authenticated-orcid":false,"given":"Marcus","family":"Quinkler","sequence":"additional","affiliation":[{"name":"Endokrinologie in Charlottenburg , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Adolf","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum , Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Handgriff","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum , Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum , Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Schneider","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum , Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Sturm","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum , Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"K\u00fcnzel","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum , Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Seidensticker","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Radiologie, LMU Klinikum, LMU M\u00fcnchen , Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Deniz","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Radiologie, LMU Klinikum, LMU M\u00fcnchen , Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Ladurner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie, LMU Klinikum , Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7826-3984","authenticated-orcid":false,"given":"Felix","family":"Beuschlein","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum , Munich, Germany"},{"name":"Klinik f\u00fcr Endokrinologie, Diabetologie und Klinische Ern\u00e4hrung, Universit\u00e4tsSpital Z\u00fcrich (USZ) and Universit\u00e4t Z\u00fcrich (UZH) , Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9817-9875","authenticated-orcid":false,"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum , Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"2023010809172378700_bib1","first-page":"51","article-title":"Cardiometabolic outcomes and mortality in medically treated primary aldosteronism: a retrospective cohort study","volume":"6","author":"Hundemer","year":"2018","journal-title":"Lancet: Diabetes and Endocrinology"},{"key":"2023010809172378700_bib2","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1210\/jc.2008-2116","article-title":"Cardiovascular and cerebrovascular comorbidities of hypokalemic and normokalemic primary aldosteronism: results of the German conn's registry","volume":"94","author":"Born-Frontsberg","year":"2009","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2023010809172378700_bib3","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.jacc.2005.01.015","article-title":"Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism","volume":"45","author":"Milliez","year":"2005","journal-title":"Journal of the American College of Cardiology"},{"key":"2023010809172378700_bib4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1055\/s-0029-1243257","article-title":"Comorbidities in primary aldosteronism","volume":"42","author":"Quinkler","year":"2010","journal-title":"Hormone and Metabolic Research"},{"key":"2023010809172378700_bib5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.tem.2005.02.010","article-title":"Aldosterone as a cardiovascular risk factor","volume":"16","author":"Rossi","year":"2005","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"2023010809172378700_bib6","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/HYPERTENSIONAHA.112.197111","article-title":"Observational study mortality in treated primary aldosteronism: the German Conn's Registry","volume":"60","author":"Reincke","year":"2012","journal-title":"Hypertension"},{"key":"2023010809172378700_bib7","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1210\/jc.2013-2805","article-title":"Long-term cardio- and cerebrovascular events in patients with primary aldosteronism","volume":"98","author":"Mulatero","year":"2013","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2023010809172378700_bib8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1161\/HYPERTENSIONAHA.113.01060","article-title":"Cardiovascular complications associated with primary aldosteronism: a controlled cross-sectional study","volume":"62","author":"Savard","year":"2013","journal-title":"Hypertension"},{"key":"2023010809172378700_bib9","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1161\/HYPERTENSIONAHA.118.11086","article-title":"Cellular and genetic causes of idiopathic hyperaldosteronism","volume":"72","author":"Omata","year":"2018","journal-title":"Hypertension"},{"key":"2023010809172378700_bib10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1210\/clinem\/dgaa484","article-title":"International histopathology consensus for unilateral primary aldosteronism","volume":"106","author":"Williams","year":"2021","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2023010809172378700_bib11","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline","volume":"101","author":"Funder","year":"2016","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2023010809172378700_bib12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1161\/HYPERTENSIONAHA.117.10596","article-title":"Adrenalectomy lowers incident atrial fibrillation in primary aldosteronism patients at long term","volume":"71","author":"Rossi","year":"2018","journal-title":"Hypertension"},{"key":"2023010809172378700_bib13","doi-asserted-by":"crossref","first-page":"32103","DOI":"10.1038\/srep32103","article-title":"Long term outcome of Aldosteronism after target treatments","volume":"6","author":"Wu","year":"2016","journal-title":"Scientific Reports"},{"key":"2023010809172378700_bib14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.coemr.2019.08.008","article-title":"Primary aldosteronism long-term outcome: medical versus surgical therapy","volume":"8","author":"Schneider","year":"2019","journal-title":"Current Opinion in Endocrine and Metabolic Research"},{"key":"2023010809172378700_bib15","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1210\/jc.2018-00617","article-title":"Cortisol excess in patients with primary aldosteronism impacts left ventricular hypertrophy","volume":"103","author":"Adolf","year":"2018","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2023010809172378700_bib16","first-page":"739","article-title":"Adrenal vein sampling versus CT scan to determine treatment in primary aldosteronism: an outcome-based randomised diagnostic trial","volume":"4","author":"Dekkers","year":"2016","journal-title":"Lancet: Diabetes and Endocrinology"},{"key":"2023010809172378700_bib17","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1161\/HYPERTENSIONAHA.118.11382","article-title":"Computed tomography and adrenal venous sampling in the diagnosis of unilateral primary aldosteronism","volume":"72","author":"Williams","year":"2018","journal-title":"Hypertension"},{"key":"2023010809172378700_bib18","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1161\/HYPERTENSIONAHA.119.13463","article-title":"Clinical outcomes of 1625 patients with primary aldosteronism subtyped with adrenal vein sampling","volume":"74","author":"Rossi","year":"2019","journal-title":"Hypertension"},{"key":"2023010809172378700_bib19","first-page":"718","article-title":"Adrenal vein sampling for subtyping in primary aldosteronism","volume":"4","author":"Reincke","year":"2016","journal-title":"Lancet: Diabetes and Endocrinology"},{"key":"2023010809172378700_bib20","doi-asserted-by":"crossref","first-page":"101400","DOI":"10.1016\/j.beem.2020.101400","article-title":"Controversies and advances in adrenal venous sampling in the diagnostic workup of primary aldosteronism","volume":"34","author":"Wolley","year":"2020","journal-title":"Best Practice and Research in Clinical Endocrinology and Metabolism"},{"key":"2023010809172378700_bib21","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.ecl.2019.08.012","article-title":"Adrenal venous sampling: where do we stand?","volume":"48","author":"Rossi","year":"2019","journal-title":"Endocrinology and Metabolism Clinics of North America"},{"key":"2023010809172378700_bib22","doi-asserted-by":"crossref","first-page":"D15","DOI":"10.1530\/EJE-18-0844","article-title":"Adrenal venous sampling: cosyntropin stimulation or not?","volume":"181","author":"Deinum","year":"2019","journal-title":"European Journal of Endocrinology"},{"key":"2023010809172378700_bib23","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1097\/HJH.0000000000002520","article-title":"Subtype diagnosis, treatment, complications and outcomes of primary aldosteronism and future direction of research: a position statement and consensus of the working group on endocrine hypertension of the European Society of Hypertension","volume":"38","author":"Mulatero","year":"2020","journal-title":"Journal of Hypertension"},{"key":"2023010809172378700_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.93136","article-title":"Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism","volume":"2","author":"Arlt","year":"2017","journal-title":"JCI Insight"},{"key":"2023010809172378700_bib25","first-page":"1","article-title":"Low-grade cortisol cosecretion has limited impact on ACTH-stimulated AVS parameters in primary aldosteronism","volume":"105","author":"O'Toole","year":"2020","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2023010809172378700_bib26","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1210\/jc.2019-00299","article-title":"Impaired glucose metabolism in primary aldosteronism is associated with cortisol cosecretion","volume":"104","author":"Gerards","year":"2019","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2023010809172378700_bib27","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1507\/endocrj.K10E-402","article-title":"Clinicopathological features of primary aldosteronism associated with subclinical Cushing's syndrome","volume":"58","author":"Hiraishi","year":"2011","journal-title":"Endocrine Journal"},{"key":"2023010809172378700_bib28","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1210\/jc.2010-2743","article-title":"Cardiovascular complications of patients with aldosteronism associated with autonomous cortisol secretion","volume":"96","author":"Nakajima","year":"2011","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2023010809172378700_bib29","doi-asserted-by":"crossref","first-page":"e2423","DOI":"10.1210\/clinem\/dgab099","article-title":"Autonomous cortisol secretion influences psychopathological symptoms in patients with primary aldosteronism","volume":"106","author":"Gendreitzig","year":"2021","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2023010809172378700_bib30","doi-asserted-by":"crossref","first-page":"E1035","DOI":"10.1210\/jc.2013-3789","article-title":"Age below 40 or a recently proposed clinical prediction score cannot bypass adrenal venous sampling in primary aldosteronism","volume":"99","author":"Riester","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2023010809172378700_bib31","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1055\/a-0672-0836","article-title":"Aldosterone to renin ratio as screening tool in primary aldosteronism","volume":"127","author":"Schilbach","year":"2019","journal-title":"Experimental and Clinical Endocrinology and Diabetes"},{"key":"2023010809172378700_bib32","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/eci.12746","article-title":"Accuracy of adrenal imaging and adrenal venous sampling in diagnosing unilateral primary aldosteronism","volume":"47","author":"Ladurner","year":"2017","journal-title":"European Journal of Clinical Investigation"},{"key":"2023010809172378700_bib33","first-page":"689","article-title":"Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort","volume":"5","author":"Williams","year":"2017","journal-title":"Lancet: Diabetes and Endocrinology"},{"key":"2023010809172378700_bib34","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1210\/jc.2019-00996","article-title":"Adrenal insufficiency after unilateral adrenalectomy in primary aldosteronism: long-term outcome and clinical impact","volume":"104","author":"Heinrich","year":"2019","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2023010809172378700_bib35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behavior Research Methods"},{"key":"2023010809172378700_bib36","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1097\/SLA.0000000000003200","article-title":"The primary aldosteronism surgical outcome score for the prediction of clinical outcomes after adrenalectomy for unilateral primary aldosteronism","volume":"272","author":"Burrello","year":"2020","journal-title":"Annals of Surgery"},{"key":"2023010809172378700_bib37","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/HYPERTENSIONAHA.117.09975","article-title":"Targeting CXCR4 (CXC chemokine receptor type 4) for molecular imaging of aldosterone-producing adenoma","volume":"71","author":"Heinze","year":"2018","journal-title":"Hypertension"},{"key":"2023010809172378700_bib38","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1007\/s00259-020-04722-0","article-title":"Imaging CXCR4 expression in patients with suspected primary hyperaldosteronism","volume":"47","author":"Ding","year":"2020","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"key":"2023010809172378700_bib39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1440-1681.1990.tb01300.x","article-title":"Some aldosterone-producing adrenal tumours also secrete cortisol, but present clinically as primary aldosteronism","volume":"17","author":"Tunny","year":"1990","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"key":"2023010809172378700_bib40","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2169\/internalmedicine1962.30.26","article-title":"Primary aldosteronism with cortisol overproduction from bilateral multiple adrenal adenomas","volume":"30","author":"Nagae","year":"1991","journal-title":"Japanese Journal of Medicine"},{"key":"2023010809172378700_bib41","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1507\/endocrj.48.103","article-title":"A case of aldosterone-producing adrenocortical adenoma associated with preclinical Cushing's syndrome and hypersecretion of parathyroid hormone","volume":"48","author":"Makino","year":"2001","journal-title":"Endocrine Journal"},{"key":"2023010809172378700_bib42","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1291\/hypres.31.1669","article-title":"A case of primary aldosteronism associated with renal artery stenosis and preclinical Cushing's syndrome","volume":"31","author":"Tsunoda","year":"2008","journal-title":"Hypertension Research"},{"key":"2023010809172378700_bib43","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s10157-008-0064-3","article-title":"Primary aldosteronism and hypercortisolism due to bilateral functioning adrenocortical adenomas","volume":"12","author":"Oki","year":"2008","journal-title":"Clinical and Experimental Nephrology"},{"key":"2023010809172378700_bib44","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1507\/endocrj.K08E-268","article-title":"Cushing's syndrome by left adrenocortical adenoma synchronously associated with primary aldosteronism by right adrenocortical adenoma: report of a case","volume":"56","author":"Onoda","year":"2009","journal-title":"Endocrine Journal"},{"key":"2023010809172378700_bib45","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/jhh.2010.35","article-title":"Difficult-to-control hypertension due to bilateral aldosterone-producing adrenocortical microadenomas associated with a cortisol-producing adrenal macroadenoma","volume":"25","author":"Morimoto","year":"2011","journal-title":"Journal of Human Hypertension"},{"key":"2023010809172378700_bib46","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12902-019-0395-y","article-title":"Hypercortisolism and primary aldosteronism caused by bilateral adrenocortical adenomas\u202f: a case report","volume":"19","author":"Ren","year":"2019","journal-title":"BMC Endocrine Disorders"},{"key":"2023010809172378700_bib47","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13256-020-2353-8","article-title":"Primary aldosteronism concurrent with subclinical Cushing's syndrome: a case report and review of the literature","volume":"14","author":"Zhang","year":"2020","journal-title":"Journal of Medical Case Reports"},{"key":"2023010809172378700_bib48","doi-asserted-by":"crossref","first-page":"150075","DOI":"10.1530\/EDM-15-0075","article-title":"Use of plasma metanephrine to aid adrenal venous sampling in combined aldosterone and cortisol over-secretion","volume":"2015","author":"Goupil","year":"2015","journal-title":"Endocrinology, Diabetes and Metabolism Case Reports"},{"key":"2023010809172378700_bib49","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/cen.12750","article-title":"Does concomitant autonomous adrenal cortisol overproduction have the potential to confound the interpretation of adrenal venous sampling in primary aldosteronism?","volume":"83","author":"Goupil","year":"2015","journal-title":"Clinical Endocrinology"},{"key":"2023010809172378700_bib50","doi-asserted-by":"crossref","first-page":"R147","DOI":"10.1530\/EJE-19-0215","article-title":"THERAPY OF ENDOCRINE DISEASE: Medical treatment of primary aldosteronism","volume":"181","author":"Lechner","year":"2019","journal-title":"European Journal of Endocrinology"},{"key":"2023010809172378700_bib51","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1055\/s-0042-124419","article-title":"Adrenal vein catecholamine levels and ratios: reference intervals derived from patients with primary aldosteronism","volume":"49","author":"Sze","year":"2017","journal-title":"Hormone and Metabolic Research"},{"key":"2023010809172378700_bib52","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1161\/HYPERTENSIONAHA.113.01601","article-title":"Plasma metanephrine for assessing the selectivity of adrenal venous sampling","volume":"62","author":"Dekkers","year":"2013","journal-title":"Hypertension"},{"key":"2023010809172378700_bib53","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1373\/clinchem.2015.251199","article-title":"Mass spectrometry-based adrenal and peripheral venous steroid profiling for subtyping primary aldosteronism","volume":"62","author":"Eisenhofer","year":"2016","journal-title":"Clinical Chemistry"},{"key":"2023010809172378700_bib54","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1161\/HYPERTENSIONAHA.117.09415","article-title":"Androstenedione and 17-\u03b1-hydroxyprogesterone are better indicators of adrenal vein sampling selectivity than cortisol","volume":"70","author":"Ceolotto","year":"2017","journal-title":"Hypertension"},{"key":"2023010809172378700_bib55","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.clinbiochem.2020.10.009","article-title":"A 3-min UPLC-MS\/MS method for the simultaneous determination of plasma catecholamines and their metabolites: method verification and diagnostic efficiency","volume":"87","author":"Jian","year":"2021","journal-title":"Clinical Biochemistry"},{"key":"2023010809172378700_bib56","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.surg.2020.05.046","article-title":"Early assessment of postoperative adrenal function is necessary after adrenalectomy for mild autonomous cortisol secretion","volume":"169","author":"Foster","year":"2021","journal-title":"Surgery"},{"key":"2023010809172378700_bib57","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/js.2017-00134","article-title":"Aldosterone-producing cell clusters frequently harbor somatic mutations and accumulate with age in normal adrenals","volume":"1","author":"Omata","year":"2017","journal-title":"Journal of the Endocrine Society"},{"key":"2023010809172378700_bib58","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1055\/s-0043-122394","article-title":"Aldosterone-producing cell clusters in normal and pathological states","volume":"49","author":"Omata","year":"2017","journal-title":"Hormone and Metabolic Research"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/187\/5\/EJE-21-0541.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/187\/5\/EJE-21-0541.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/187\/5\/637\/48515721\/eje-21-0541.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/187\/5\/637\/48515721\/eje-21-0541.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:16:50Z","timestamp":1676391410000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/187\/5\/637\/6972054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,11,1]]}},"URL":"https:\/\/doi.org\/10.1530\/eje-21-0541","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,11]]},"published":{"date-parts":[[2022,9,29]]}}}