{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:55:20Z","timestamp":1788479720817,"version":"build-2803163510"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>Transsphenoidal surgery (TSS) is mainly indicated in prolactinomas when dopamine agonist treatment fails. However, there is no established early predictor of cabergoline (CBG) response. The present study was aimed to identify predictors of CBG resistance in order to select patients who may benefit from early TSS.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design<\/jats:title>\n<jats:p>Retrospective longitudinal study.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>We reviewed the medical record of patients diagnosed with prolactinoma after 2010. Inclusion criteria: macroprolactinomas under CBG treatment with serial prolactin levels and MRI before treatment and 3 and 12 months afterwards. The main outcome was tumour size shrinkage \u2265 50% (using the two largest diameters in sagittal view) after 12 months of CBG (TS_50). The capacity of the most important clinical and biochemical variables in predicting the main outcome was examined.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 185 prolactinomas where included: 124 (67.0%) were microadenomas and 61 (33.0%) were macroadenomas of which 27 patients meet de inclusion criteria; median age (42.5 years; (IQR: 28.0)). The median follow-up was (67.5 months; (IQR: 30.2)). Ten patients (37.0%) underwent surgery after more than 1 year of CBG. The volume reduction at the first MRI (3\u20134 months) was the unique valuable predictor: (OR: 1.16 (95% CI: 1.02\u20131.32)) of TS_50. A tumour volume shrinkage of \u2265 30% in the first 3\u20134 months of CBG therapy predicts TS_50 with an AUC (0.95 (CI: 0.76\u20130.99)).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Tumour shrinkage in the first 3\u20134 months after starting treatment with CBG is a good tool for predicting the long-term response and can help clinicians to take more appropriated and personalized decisions.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-21-0561","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T15:37:38Z","timestamp":1628609858000},"page":"587-595","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":22,"title":["Shrinkage by the third month predicts long-term response of macroprolactinoma after cabergoline"],"prefix":"10.1093","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-4343","authenticated-orcid":true,"given":"Betina","family":"Biagetti","sequence":"first","affiliation":[{"name":"1Diabetes and Metabolism Research Unit, Vall d\u2019Hebron University Hospital and Vall d'Hebron Research Institute (VHIR), Universidad Aut\u00f3noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Sarria-Estrada","sequence":"additional","affiliation":[{"name":"2Neuroradiology Section, Radiology Department"},{"name":"5Department of Autonomous, University of Barcelona (UAB), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiken Karelys","family":"Ng-Wong","sequence":"additional","affiliation":[{"name":"2Neuroradiology Section, Radiology Department"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Martinez-Saez","sequence":"additional","affiliation":[{"name":"3Pathology Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Caster\u00e0s","sequence":"additional","affiliation":[{"name":"1Diabetes and Metabolism Research Unit, Vall d\u2019Hebron University Hospital and Vall d'Hebron Research Institute (VHIR), Universidad Aut\u00f3noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Cordero Asanza","sequence":"additional","affiliation":[{"name":"4Neurosurgery and Neurotraumatology, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Hernandez","sequence":"additional","affiliation":[{"name":"1Diabetes and Metabolism Research Unit, Vall d\u2019Hebron University Hospital and Vall d'Hebron Research Institute (VHIR), Universidad Aut\u00f3noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Giralt-Arnaiz","sequence":"additional","affiliation":[{"name":"6Department of Biochemistry, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Sim\u00f2","sequence":"additional","affiliation":[{"name":"1Diabetes and Metabolism Research Unit, Vall d\u2019Hebron University Hospital and Vall d'Hebron Research Institute (VHIR), Universidad Aut\u00f3noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/185\/4\/EJE-21-0561.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/185\/4\/EJE-21-0561.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:16:52Z","timestamp":1676391412000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/185\/4\/587\/6654393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,1]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/eje-21-0561","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,1]]}}}