{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:17:41Z","timestamp":1792210661610,"version":"4.4.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>Pituitary adenoma (PA) is one of the three major components of multiple endocrine neoplasia type 1 (MEN1). Recent studies have suggested that MEN1-associated PAs are less aggressive than initially estimated. We propose an analysis of the outcome of PAs with a standard of care treatment in a nationwide cohort of MEN1 patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design<\/jats:title>\n<jats:p>Retrospective observational nationwide cohort study using the MEN1 patient registry from the French Group of Endocrine Tumours (GTE).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The GTE database population consists of 1435 patients with MEN1. This analysis focused on 551 patients recruited after 2000 with at least 3 years of follow-up. The study outcome was tumour progression of PA defined by an increase in Hardy classification (HC) during follow-up according to referring physician regular reports.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Among 551 MEN1 patients (index and related), 202 (36.7%) had PA, with 114 (56.4%) diagnosed by MEN1-related screening. PAs were defined according to HC as microadenoma (grade I) in 117 cases (57.9%), macroadenoma in 59 (29.2%) with 20 HC grade II and 39 HC grades III\u2013IV and unspecified in 26 (12.8%). They were prolactinomas in 92 cases (45.5%) and non-secreting in 73 (36.1%). After a median follow-up of 3 years among the 137 patients with HC grades I\u2013II, 4 patients (2.9%) presented tumour progression.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>PAs in patients with MEN1 are less aggressive than previously thought. Tumour progression is rare with a standard of care monitoring and treatment, especially in related patients who mostly present non-secreting microadenoma. MRI monitoring for asymptomatic MEN1 patients should be reduced accordingly.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-21-0630","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T13:45:25Z","timestamp":1634046325000},"page":"863-873","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":34,"title":["Pituitary adenoma in patients with multiple endocrine neoplasia type 1: a cohort study"],"prefix":"10.1093","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8097-3862","authenticated-orcid":true,"given":"Maelle","family":"Le Bras","sequence":"first","affiliation":[{"name":"1CHU de Nantes PHU2 Institut du Thorax et du Syst\u00e8me Nerveux, Service d\u2019Endocrinologie, Diab\u00e9tologie et Nutrition, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Leclerc","sequence":"additional","affiliation":[{"name":"2Centre Hospitalier de La Roche sur Yon, Department of Endocrinology and Diabetology, La Roche sur Yon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Rousseau","sequence":"additional","affiliation":[{"name":"3INSERM CIC 1413, Clinique des Donn\u00e9es, CHU de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Goudet","sequence":"additional","affiliation":[{"name":"4University Hospital Dijon, Endocrine Surgery, H\u00f4pital du Bocage, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Cuny","sequence":"additional","affiliation":[{"name":"5Department of Endocrinology, Hopital de la Conception, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1808-8800","authenticated-orcid":true,"given":"Frederic","family":"Castinetti","sequence":"additional","affiliation":[{"name":"6Aix-Marseille Universit\u00e9, Assistance-Publique-H\u00f4pitaux de Marseille, Centre de R\u00e9f\u00e9rence des Maladies Rares d\u2019Origine Hypophysaire, Department of endocrinology, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Bauters","sequence":"additional","affiliation":[{"name":"7CHU Lille, Service d\u2019Endocrinologie, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5096-5722","authenticated-orcid":true,"given":"Philippe","family":"Chanson","sequence":"additional","affiliation":[{"name":"8Assistance Publique-H\u00f4pitaux de Paris, Endocrinology, Le Kremlin-Bic\u00eatre, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Tabarin","sequence":"additional","affiliation":[{"name":"9Department of Endocrinology, H\u00f4pital Haut L\u00e9v\u00eaque-CHU de Bordeaux, Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Gaujoux","sequence":"additional","affiliation":[{"name":"10Hopital Cochin, Digestive and Endocrine Surgery, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Christin-Maitre","sequence":"additional","affiliation":[{"name":"11Hopital Saint-Antoine, Endocrine Unit, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Ruszniewski","sequence":"additional","affiliation":[{"name":"12Department of Gastroenterology and Pancreatology, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Beaujon Hospital, Paris Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise","family":"Borson-Chazot","sequence":"additional","affiliation":[{"name":"13Hospices Civils de Lyon, F\u00e9d\u00e9ration d\u2019Endocrinologie Groupement Hospitalier Est, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Guilhem","sequence":"additional","affiliation":[{"name":"14Centre Hospitalier Universitaire de Rennes, H\u00f4pital Sud, Service d\u2019Endocrinologie-Diab\u00e9tologie-Nutrition, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Caron","sequence":"additional","affiliation":[{"name":"15CHU Toulouse, Endocrinology and Metabolic diseases, Service d\u2019Endocrinologie, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Goichot","sequence":"additional","affiliation":[{"name":"16H\u00f4pital de Hautepierre, Service de Medecine Interne et Nutrition, Strasbourg Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Beckers","sequence":"additional","affiliation":[{"name":"17CHU de Li\u00e8ge, Service d\u2019Endocrinologie, Domaine Univeritaire du Sart-Tilman, 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