{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:56:31Z","timestamp":1747198591794,"version":"3.40.5"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"\nObjective<\/jats:title>\nStudies that evaluated the genetic influences on thyroid-stimulating hormone (TSH) concentrations were primarily performed in twin cohorts. The aim of this study was to investigate the sex-specific association of serum TSH concentrations between parents and their offspring.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nWe used data from the population-based Heinz Nixdorf Recall Study and the associated MultiGeneration Study, including offspring and their biological parents. In 3115 participants (including 1558 offspring from 1138 families), self-reported thyroid diseases and median TSH concentrations depending on thyroid status were assessed. Familial associations of TSH concentrations were investigated in 1485 healthy subjects using linear regression modeling in each group of the parent\u2013offspring relationship using the parent\u2019s TSH concentration as the exposure of interest. To account for the family effect, a mixed\u2010effects ordinal logistic regression model with random intercept varying at the family level was fitted, using the TSH concentration of the offspring classified into sex- and age-specific quartiles as the outcome.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nFor every 1 mIU\/L increase in the mother\u2019s or father\u2019s TSH concentration, the daughter\u2019s TSH concentration increases by 0.13 mIU\/L (95% CI: \u22120.01;<\/jats:bold> 0.27) and 0.19 mIU\/L (0.05; 0.33), respectively, and the son\u2019s TSH concentration increases by 0.13 mIU\/L (0.02; 0.25) and 0.20 mIU\/L (0.08; 0.32), respectively. Further sensitivity analyses by expanding inclusion criteria and taking family clustering into account corroborated these results.<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nSerum TSH concentrations of parents are positively associated with those of their offspring in all sex-specific relationships.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-21-0652","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T20:14:03Z","timestamp":1634933643000},"page":"855-862","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":1,"title":["TSH concentrations in parents and their offspring: a cross-sectional family-based analysis"],"prefix":"10.1093","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3888-3967","authenticated-orcid":true,"given":"Carolin","family":"Girschik","sequence":"first","affiliation":[{"name":"1Institute of Medical Informatics, Biometry and Epidemiology"},{"name":"2Department of Endocrinology, Diabetes and Metabolism, University Hospital Essen, University of Duisburg-Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie-Charlotte","family":"Drogge","sequence":"additional","affiliation":[{"name":"1Institute of Medical Informatics, Biometry and Epidemiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Kowall","sequence":"additional","affiliation":[{"name":"1Institute of Medical Informatics, Biometry and Epidemiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Lehmann","sequence":"additional","affiliation":[{"name":"1Institute of Medical Informatics, Biometry and Epidemiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Stang","sequence":"additional","affiliation":[{"name":"1Institute of Medical Informatics, Biometry and Epidemiology"},{"name":"3Department of Epidemiology, School of Public Health, Boston University, Boston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Zwanziger","sequence":"additional","affiliation":[{"name":"2Department of Endocrinology, Diabetes and Metabolism, University Hospital Essen, University of Duisburg-Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raimund","family":"Erbel","sequence":"additional","affiliation":[{"name":"1Institute of Medical Informatics, Biometry and Epidemiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"F\u00fchrer","sequence":"additional","affiliation":[{"name":"2Department of Endocrinology, Diabetes and Metabolism, University Hospital Essen, University of Duisburg-Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Heinz","family":"J\u00f6ckel","sequence":"additional","affiliation":[{"name":"1Institute of Medical Informatics, Biometry and Epidemiology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/185\/6\/EJE-21-0652.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/185\/6\/EJE-21-0652.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:16:59Z","timestamp":1676391419000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/185\/6\/855\/6654338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1530\/eje-21-0652","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"type":"print","value":"0804-4643"},{"type":"electronic","value":"1479-683X"}],"subject":[],"published":{"date-parts":[[2021,12,1]]}}}