{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:12:29Z","timestamp":1793059949427,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>Conventional diagnostic methods are limited in their ability to differentiate destructive thyroiditis from Graves\u2019 disease. We hypothesised that serum diiodotyrosine (DIT) and monoiodotyrosine (MIT) levels could be biomarkers for differentiating destructive thyroiditis from Graves\u2019 disease.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design<\/jats:title>\n<jats:p>Patients with destructive thyroiditis (<jats:italic>n<\/jats:italic>\u2009\u2009=\u200913) and Graves\u2019 disease (<jats:italic>n<\/jats:italic>\u2009\u2009=\u200922) were enrolled in this cross-sectional study.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>We assayed the serum DIT and MIT levels using liquid chromatography-tandem mass spectrometry. A receiver operating characteristic (ROC) curve analysis was used to determine the sensitivity and specificity of the serum DIT and MIT levels as biomarkers for differentiating destructive thyroiditis from Graves\u2019 disease.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The serum DIT and MIT levels were significantly higher in patients with destructive thyroiditis than in those with Graves\u2019 disease. The ROC curve analysis showed that the serum DIT levels (\u2265359.9 pg\/mL) differentiated destructive thyroiditis from Graves\u2019 disease, significantly, with 100.0% sensitivity and 95.5% specificity (<jats:italic>P<\/jats:italic> &lt; 0.001). The diagnostic accuracy of the serum MIT levels (\u2265119.4 pg\/mL) was not as high as that of the serum DIT levels (sensitivity, 84.6%; specificity, 77.3%; <jats:italic>P<\/jats:italic>\u2009=\u20090.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The serum DIT levels may serve as a novel diagnostic biomarker for differentiating destructive thyroiditis from Graves\u2019 disease.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-21-0901","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T17:13:08Z","timestamp":1638897188000},"page":"245-253","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":8,"title":["Serum diiodotyrosine \u2013 a biomarker to differentiate destructive thyroiditis from Graves\u2019 disease"],"prefix":"10.1093","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5469-0153","authenticated-orcid":true,"given":"Naoya","family":"Fujita","sequence":"first","affiliation":[{"name":"1Department of General Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Ono","sequence":"additional","affiliation":[{"name":"1Department of General Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azusa","family":"Sano","sequence":"additional","affiliation":[{"name":"1Department of General Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Kimata","sequence":"additional","affiliation":[{"name":"1Department of General Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seigo","family":"Oyama","sequence":"additional","affiliation":[{"name":"1Department of General Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"1Department of General Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuya","family":"Sato","sequence":"additional","affiliation":[{"name":"2ASKA Pharmaceutical Co., Ltd., Minato-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Kudo","sequence":"additional","affiliation":[{"name":"2ASKA Pharmaceutical Co., Ltd., Minato-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimichi","family":"Miyashiro","sequence":"additional","affiliation":[{"name":"3ASKA Pharma Medical Co., Ltd., Fujisawa, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Fujikata","sequence":"additional","affiliation":[{"name":"3ASKA Pharma Medical Co., Ltd., Fujisawa, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"1Department of General Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/186\/2\/EJE-21-0901.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/downloadpdf\/journals\/eje\/186\/2\/EJE-21-0901.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:17:18Z","timestamp":1676391438000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/186\/2\/245\/6852978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,1]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/eje-21-0901","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,1]]}}}