{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:22:12Z","timestamp":1772580132369,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>Over the past decade, the growth hormone (GH) nadir cut-off during the oral glucose tolerance test for remission in patients with acromegaly was changed from 0.4 to 1.0 \u03bcg\/L due to the limited use of ultrasensitive detection kits to measure GH levels. However, the optimal cut-off level for GH nadir remains unclear. This retrospective study aimed to investigate the association between different GH nadir cut-offs and prognosis in patients with acromegaly.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design and methods<\/jats:title>\n<jats:p>A total of 285 patients with acromegaly with a glucose-suppressed GH nadir &lt;1 \u03bcg\/L at 3\u20136 months after trans-sphenoidal adenomectomy were divided into two groups according to the glucose-suppressed GH nadir levels at 3\u20136 months post-operatively (group A: &lt;0.4 \u03bcg\/L; group B: 0.4\u20131.0 \u03bcg\/L). GH levels were measured using an ultrasensitive IRMA. The clinical, hormonal, metabolic, and neuroradiological data of the two groups were compared.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Female sex, as well as confirmed macroadenomas, was significantly overrepresented in group B. The 5-year rate of patients who achieved nadir GH &lt; 1.0 \u03bcg\/L and age- and sex-matched normal IGF-1 was significantly higher in group A than that in group B. However, there was no significant difference between the two groups in metabolic parameters at 12 months post-operatively.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Different GH nadir cut-offs were associated with different 5-year rates of patients who achieved nadir GH &lt;1.0 \u03bcg\/L and age- and sex-matched normal IGF-1, suggesting that a strict GH nadir threshold of 0.4 \u03bcg\/L correlates better with remission.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-21-1094","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T17:39:36Z","timestamp":1649180376000},"page":"657-665","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":6,"title":["Revisiting growth hormone nadir cut-offs for remission in patients with acromegaly"],"prefix":"10.1093","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-4587","authenticated-orcid":true,"given":"Jiwon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea"},{"name":"Endocrinology, Institute of Endocrine Research, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"},{"name":"Yonsei University Graduate School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon-a","family":"Hwang","sequence":"additional","affiliation":[{"name":"Endocrinology, Institute of Endocrine Research, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"},{"name":"Pituitary Tumor Center, Severance Hospital, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yae Won","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Hyung","family":"Moon","sequence":"additional","affiliation":[{"name":"Pituitary Tumor Center, Severance Hospital, Seoul, Republic of Korea"},{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2523-7122","authenticated-orcid":true,"given":"Eui Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Pituitary Tumor Center, Severance Hospital, Seoul, Republic of Korea"},{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Won","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jig","family":"Lee","sequence":"additional","affiliation":[{"name":"Endocrinology, Institute of Endocrine Research, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"},{"name":"Pituitary Tumor Center, Severance Hospital, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8693-9630","authenticated-orcid":true,"given":"Cheol Ryong","family":"Ku","sequence":"additional","affiliation":[{"name":"Endocrinology, Institute of Endocrine Research, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"},{"name":"Pituitary Tumor Center, Severance Hospital, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"bib1","series-title":"Journal of Clinical Investigation","doi-asserted-by":"publisher","first-page":"3189","DOI":"10.1172\/JCI39375","article-title":"Acromegaly pathogenesis and treatment","volume":"119","author":"Melmed","year":"2009","unstructured":"Melmed SAcromegaly pathogenesis and treatment. 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