{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:50:03Z","timestamp":1762660203531,"version":"3.40.5"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Sodium homeostasis is disrupted in many cardiovascular diseases, which makes non-invasive sodium storage assessment desirable. In this regard, sodium MRI has shown its potential to reveal differences in sodium content between healthy and diseased tissues as well as treatment-related changes of sodium content. When different tissues are affected disparately, simultaneous assessment of these compartments is expected to provide better information about sodium distribution, reduce examination time, and improve clinical efficiency.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objectives<\/jats:title>\n<jats:p>The objectives were (1) to investigate sodium storage levels in calf and pectoral muscle in healthy controls and patients and quantify changes following medical treatment and (2) to demonstrate homogeneous disruption in skeletal muscle sodium storage in patients with primary hyperaldosteronism (PHA).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>We assessed sodium storage levels (relative sodium signal intensity, rSSI) in the calf and pectoral muscles of eight patients with PHA prior and after treatment and 12 age- and sex-matched healthy volunteers.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Calf and pectoral muscle compartments exhibited similar sodium content both in healthy subjects (calf vs pectoral rSSI: 0.14 \u00b1 0.01 vs 0.14 \u00b1 0.03) and PHA patients (calf vs pectoral rSSI: 0.19 \u00b1 0.03 vs 0.18 \u00b1 0.03). Further, we observed similar treatment-related changes in pectoral and calf muscles in the patients (proportional rSSI change calf: 26%; pectoral: 28%).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>We found that sodium was distributed uniformly and behaved equally in different skeletal muscles in Conn\u2019s syndrome. This allows to measure both heart and skeletal muscle sodium signals simultaneously by a single measurement without repositioning the patient. This increases <jats:sup>23<\/jats:sup>Na-MRI\u2019s clinical feasibility as an innovative technique to monitor sodium storage.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-22-0074","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T17:23:41Z","timestamp":1646673821000},"page":"K33-K38","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":9,"title":["Primary hyperaldosteronism induces congruent alterations of sodium homeostasis in different skeletal muscles: a 23Na-MRI study"],"prefix":"10.1093","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8703-7644","authenticated-orcid":true,"given":"Martin","family":"Christa","sequence":"first","affiliation":[{"name":"University and University Hospital W\u00fcrzburg, Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"},{"name":"University Hospital W\u00fcrzburg, Medical Clinic and Polyclinic for Internal Medicine I, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1616-8986","authenticated-orcid":true,"given":"Stefanie","family":"Hahner","sequence":"additional","affiliation":[{"name":"University Hospital W\u00fcrzburg, Medical Clinic and Polyclinic for Internal Medicine I, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6207-9226","authenticated-orcid":true,"given":"Herbert","family":"K\u00f6stler","sequence":"additional","affiliation":[{"name":"University and University Hospital W\u00fcrzburg, Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"},{"name":"Department of Diagnostic and Interventional Radiology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4652-7313","authenticated-orcid":true,"given":"Wolfgang Rudolf","family":"Bauer","sequence":"additional","affiliation":[{"name":"University and University Hospital W\u00fcrzburg, Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"},{"name":"University Hospital W\u00fcrzburg, Medical Clinic and Polyclinic for Internal Medicine I, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-7249","authenticated-orcid":true,"given":"Stefan","family":"St\u00f6rk","sequence":"additional","affiliation":[{"name":"University and University Hospital W\u00fcrzburg, Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"},{"name":"University Hospital W\u00fcrzburg, Medical Clinic and Polyclinic for Internal Medicine I, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8943-3539","authenticated-orcid":true,"given":"Andreas Max","family":"Weng","sequence":"additional","affiliation":[{"name":"University and University Hospital W\u00fcrzburg, Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"},{"name":"Department of Diagnostic and Interventional Radiology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"bib1","series-title":"European Heart Journal: Cardiovascular Imaging","first-page":"263","article-title":"Increased myocardial sodium signal intensity in Conn\u2019s syndrome detected by 23Na magnetic resonance imaging","volume":"20","author":"Christa","year":"2019","unstructured":"Christa MWeng AMGeier BW\u00f6rmann CScheffler ALehmann LOberberger JKraus BJHahner SSt\u00f6rk SIncreased myocardial sodium signal intensity in Conn\u2019s syndrome detected by 23Na magnetic resonance imaging. 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