{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:32Z","timestamp":1787022812305,"version":"build-2736575974"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In Cushing\u2019s disease (CD), detection of an adenoma by MRI is challenging. The aim of this study is to compare real-life MRI in the initial diagnostic workup of CD with high-quality MRI performed in a tertiary center for pituitary diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 139 patients with CD who underwent primary transsphenoidal surgery (TSS) in our department and had both an MRI conducted at a different institution (external MRI; extMRI) and an MRI conducted at our institution (internal MRI; intMRI). Preoperative interpretation of MRI was performed independently by an external radiologist (extRAD), an internal neuroradiologist (intRAD) and a pituitary surgeon (SURG). Intraoperative detection of an adenoma and endocrinological remission provided proof of the true adenoma localization in 105 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Interpretation of extMRI by extRAD and SURG was concordant in only 64% (89\/139) of cases, while 74.1% (103\/139) concordance was observed for interpretation of intMRI by intRAD and SURG. Based on extMRI, the true localization of the adenoma was correctly predicted in only 46.7% of the patients by extRAD and in 65.7% by SURG. In contrast, the sensitivity to correctly identify the adenoma on intMRI was 80.0% for intRAD and 94.3% for SURG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both the quality of MRI and the reader\u2019s experience are paramount for detection of microadenomas in CD. Every effort should be made to perform high-quality initial MRI according to current standards and to ensure rating by an expert in pituitary imaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eje-22-0180","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T07:36:00Z","timestamp":1656920160000},"page":"349-359","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-7","source":"Crossref","is-referenced-by-count":13,"title":["The importance of MRI quality and reader\u2019s experience for detecting an adenoma in Cushing\u2019s disease"],"prefix":"10.1093","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2226-4958","authenticated-orcid":true,"given":"Isabella","family":"Nasi-Kordhishti","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Eberhard-Karls-University, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Grimm","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Eberhard-Karls-University, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Giese","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Eberhard-Karls-University, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin N\u00f3ra","family":"L\u00f6rincz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Eberhard-Karls-University, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3205-4631","authenticated-orcid":true,"given":"Benjamin","family":"Bender","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Eberhard-Karls-University, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7249-8077","authenticated-orcid":true,"given":"J\u00fcrgen","family":"Honegger","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Eberhard-Karls-University, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"bib1","series-title":"Der Nervenarzt","first-page":"568","article-title":"Pituitary adenomas","volume":"90","author":"Honegger","year":"2019","unstructured":"Honegger JNasi-Kordhishti IGiese S. 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(https:\/\/doi.org\/10.1055\/s-2007-980192)10.1055\/s-2007-980192"},{"key":"bib5","series-title":"Neurosurgical Focus","article-title":"Evaluation and management of Cushing syndrome in cases of negative sellar magnetic resonance imaging","volume":"23","author":"Jagannathan","year":"2007","unstructured":"Jagannathan JSheehan JPJane Jr JA. Evaluation and management of Cushing syndrome in cases of negative sellar magnetic resonance imaging. Neurosurgical Focus200723 E3. (https:\/\/doi.org\/10.3171\/foc.2007.23.3.4)"},{"key":"bib6","series-title":"Clinical Endocrinology","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1111\/j.1365-2265.2011.04279.x","article-title":"Diagnosis and therapy for Cushing\u2019s disease with negative dynamic MRI finding: a single-centre experience","volume":"76","author":"Sun","year":"2012","unstructured":"Sun YSun QFan CShen JZhao WGuo YSu TWang WNing GBian L. Diagnosis and therapy for Cushing\u2019s disease with negative dynamic MRI finding: a single-centre experience. Clinical Endocrinology201276868\u2013876. (https:\/\/doi.org\/10.1111\/j.1365-2265.2011.04279.x)10.1111\/j.1365-2265.2011.04279.x"},{"key":"bib7","series-title":"European Journal of Endocrinology","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1530\/eje.1.02332","article-title":"The usefulness of combined biochemical tests in the diagnosis of Cushing\u2019s disease with negative pituitary magnetic resonance imaging","volume":"156","author":"Testa","year":"2007","unstructured":"Testa RMAlbiger NOcchi GSanguin FScanarini MBerlucchi SGardiman MPCarollo CMantero FScaroni C. The usefulness of combined biochemical tests in the diagnosis of Cushing\u2019s disease with negative pituitary magnetic resonance imaging. European Journal of Endocrinology2007156241\u2013248. 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