{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:48:13Z","timestamp":1761518893444},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1995,12]]},"abstract":"<jats:p>Sachmechi I, Schussler GC. Familial dysalbuminemic hyperthyroxinemia in pregnancy. Eur J Endocrinol 1995;133:729\u201331. ISSN 0804\u20134643<\/jats:p>\n        <jats:p>A 16-year-old pregnant Puerto Rican woman who had been treated for thyrotoxicosis previously was evaluated for goiter, increased total thyroxine (T<jats:sub>4<\/jats:sub>) and triiodothyronine (T<jats:sub>3<\/jats:sub>) and free T<jats:sub>4<\/jats:sub> estimate, despite a normal thyroid-stimulating hormone (TSH) concentration. These findings are consistent with a TSH-producing pituitary adenoma or the syndrome of generalized thyroid hormone resistance. However, sera from the patient, her mother and subsequently her newborn daughter demonstrated the increased albumin binding of T<jats:sub>4<\/jats:sub> but not T<jats:sub>3<\/jats:sub> that is characteristic of familial dysalbuminemic hyperthyroxinemia (FDH). The free T<jats:sub>4<\/jats:sub> estimate had been elevated artefactually by the increased affinity of FDH albumin for the analog in a one-step assay. The T<jats:sub>3<\/jats:sub> and T<jats:sub>4<\/jats:sub> concentrations were increased by pregnancy and T<jats:sub>4<\/jats:sub> was increased further by FDH. This first report of FDH recognized during pregnancy emphasizes that the effects of pregnancy on thyroid hormone and TSH concentrations complicate the diagnosis of FDH. It is particularly important to distinguish this benign condition from thyrotoxicosis during pregnancy, because inappropriate treatment may affect fetal development.<\/jats:p>\n        <jats:p>Issac Sachmechi, Dept. of Medicine, Queens Hospital Center, 82-68 164th Street, Queens, New York, USA<\/jats:p>","DOI":"10.1530\/eje.0.1330729","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T22:12:49Z","timestamp":1229379169000},"page":"729-731","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":5,"title":["Familianl dysalbuminemic hyperthyroxinemia in pregnancy"],"prefix":"10.1093","volume":"133","author":[{"given":"Issac","family":"Sachmechi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George C","family":"Schussler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/133\/6\/eje_133_6_014.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/133\/6\/eje_133_6_014.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:21:22Z","timestamp":1676391682000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/133\/6\/729\/6755042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1530\/eje.0.1330729","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,12]]}}}