{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:49:15Z","timestamp":1771627755926,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:p>Valdemarsson S, Leckstr\u00f6m A, Westermark P, Bergenfelz A. Increased plasma levels of islet amyloid polypeptide in patients with primary hyperparathyroidism. Eur J Endocrinol 1996;134:320\u20135. ISSN 0804\u20134643<\/jats:p>\n        <jats:p>Amylin, also named islet amyloid polypeptide (IAPP), is a protein that is processed and released from pancreatic \u03b2-cells in parallel with insulin. Islet amyloid polypeptide is currently studied with regard to a role for insulin resistance in non-insulin-dependent diabetes. To elucidate a possible function of IAPP for impaired glucose tolerance in primary hyperparathyroidism (pHPT), we studied plasma IAPP levels during an oral glucose tolerance test (OGTT) in seven pHPT patients before and 8 weeks after surgery and in six healthy subjects. The \u03b2-glucose level of the patient groups was 4.34 \u00b1 0.12 mmol\/l before and 3.97 \u00b1 0.16 mmol\/l after surgery (NS), while the serum level of insulin was significantly higher before (16.9 \u00b1 2.8 mIU\/l) than after (8.9 \u00b1 1.9 mIU\/l) the operation (p &lt; 0.05), indicating a moderately increased insulin resistance in pHPT. The basal plasma levels of IAPP were significantly higher in pHPT patients before than 8 weeks after surgery (9.71 \u00b1 1.05 and 4.30 \u00b1 0.82 pmol\/l, respectively; p &lt; 0.01). When compared to the plasma IAPP level of the controls at 1.80 \u00b1 0.38 pmol\/l, pHPT patients had higher IAPP values both before (p &lt; 0.01) and at 8 weeks after (p &lt; 0.05) operation, There was a significant correlation between the serum levels of insulin and plasma levels of IAPP in pHPT patients before (r = 0.87, p &lt; 0.01) as wells as 8 weeks after surgery (r = 0.69, p &lt; 0.05). The area under the curve for IAPP during OGTT in pHPT patients was 1872.4 \u00b1 187.7 pmol\u00b7min\/l, which is significantly higher than after surgery 1010.8 \u00b1 93.7 pmol\u00b7 min\/l) (p &lt; 0.05) and compared to the area for the controls at 840.3 \u00b1 49.9 pmol min\/l (p&lt; 0.01). In conclusion, pHPT is associated with an increased plasma level of IAPP, correlated to the serum insulin level, but persistently higher than in controls also 8 weeks after surgery. Possibly, increased IAPP levels can have a role for impaired glucose tolerance in pHPT. The hyperparathyroid state might have a specific role for the release of this peptide, otherwise closely connected to insulin secretion.<\/jats:p>\n        <jats:p>Stig Valdemarsson, Department of Internal Medicine, Lund University Hospital, S-221 85 Lund, Sweden<\/jats:p>","DOI":"10.1530\/eje.0.1340320","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T22:12:49Z","timestamp":1229379169000},"page":"320-325","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":13,"title":["Increased plasma levels of islet amyloid polypeptide in patients with primary hyperparathyroidism"],"prefix":"10.1093","volume":"134","author":[{"given":"Stig","family":"Valdemarsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold","family":"Leckstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Westermark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Bergenfelz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/134\/3\/eje_134_3_011.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/134\/3\/eje_134_3_011.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:21:46Z","timestamp":1676391706000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/134\/3\/320\/6750925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/eje.0.1340320","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3]]}}}