{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:29:52Z","timestamp":1774686592387,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p><jats:italic>Aim:<\/jats:italic> This study was undertaken to examine the effects of long-term vitamin D treatment on calcium, phosphate and magnesium homeostasis at organ level in hypoparathyroid patients.<\/jats:p>\n        <jats:p><jats:italic>Methods:<\/jats:italic> Fifteen vitamin D-treated hypoparathyroid patients were studied, eight of the patients in a combined <jats:sup>47<\/jats:sup>Ca kinetic and calcium, phosphate and magnesium balance study. Results were compared with a matched control group of 12 normal individuals.<\/jats:p>\n        <jats:p><jats:italic>Results:<\/jats:italic> All the patients had normal serum levels of calcium, phosphate and magnesium. Absolute intestinal calcium absorption was increased (<jats:italic>P<\/jats:italic> &lt;00001). Urinary calcium excretion was normal, but active tubular calcium reabsorption (<jats:italic>T<\/jats:italic><jats:sub>m<\/jats:sub>Ca\/glomerular filtration rate) was low (<jats:italic>P<\/jats:italic>&lt;0\u00b7001). Bone resorption rates and bone mineralization rates were very low (<jats:italic>P<\/jats:italic> &lt;0001 and <jats:italic>P<\/jats:italic> &lt;0\u00b705). Twenty-four-hour urinary hydroxyproline excretion and serum cross-linked carboxyterminal telopeptide of type I were in the upper normal range. Serum alkaline phosphatase was normal, but serum carboxyterminal propeptide of human type I procollagen and serum osteocalcin were significantly reduced (<jats:italic>P<\/jats:italic> &lt;0\u00b705). Calcium balance was positive and significantly different from controls (<jats:italic>P<\/jats:italic> &lt;0\u00b7001). All parameters from phosphate homeostasis were normal. Intestinal magnesium absorption was low though not significantly different from normal (<jats:italic>P<\/jats:italic> = 0\u00b706). Urinary excretion of magnesium was not significantly higher than normal, but renal magnesium reabsorption was reduced (<jats:italic>P<\/jats:italic> &lt;0\u00b7001). Magnesium balance was low, though the difference was not significant (<jats:italic>P<\/jats:italic> &lt;0\u00b706).<\/jats:p>\n        <jats:p><jats:italic>Conclusion:<\/jats:italic> Long-term vitamin D treatment in hypoparathyroid patients resulted in a positive calcium balance. Bone turnover was very low. Results of bone markers and resorption rate were conflicting. Vitamin D treatment apparently normalized the abnormalities previously found in phosphate homeostasis of hypoparathyroid patients. Magnesium homeostasis was disturbed, with a more negative balance compared with normal subjects, implying a state of magnesium deficiency in these patients.<\/jats:p>\n        <jats:p><jats:italic>European Journal of Endocrinology<\/jats:italic> <jats:bold>136<\/jats:bold> 52\u201360<\/jats:p>","DOI":"10.1530\/eje.0.1360052","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T22:12:49Z","timestamp":1229379169000},"page":"52-60","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":28,"title":["Effect of vitamin D treatment in hypoparathyroid patients: a study on calcium, phosphate and magnesium homeostasis"],"prefix":"10.1093","volume":"136","author":[{"given":"Lene","family":"Mortensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Hyldstrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peder","family":"Charles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/136\/1\/eje_136_1_012.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/136\/1\/eje_136_1_012.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:23:11Z","timestamp":1676391791000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/136\/1\/52\/6753653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/eje.0.1360052","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1]]}}}