{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:43:10Z","timestamp":1783633390205,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the usefulness of the combination of Tc-sestamibi\/Tc-pertechnetate subtraction scintigraphy (SS) and high-resolution neck ultrasonography (US) in patients with primary hyperparathyroidism (pHPT) undergoing parathyroidectomy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and Methods<\/jats:title>\n                  <jats:p>Ninety-one patients with proved pHPT were studied, excluding patients with persistent or recurrent disease. There were 65 (71.4%) women and 26 (28.6%) men, with a median age of 59 years (range 18-78 years). All patients underwent both SS and US prior to surgery, and the results were compared with operative and histological findings. The intraoperative quick-parathyroid hormone assay was available for 52 (57.1%) patients. When multiglandular disease was found, both SS and US were considered truly positive only when at least two enlarged parathyroid (PT) glands had been localized.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eighty-three (91.2%) solitary PT adenomas and three (3.3%) carcinomas were found. Moreover, two (2.2%) patients had a double adenoma and three (3.3%) patients had diffuse PT hyperplasia. The overall sensitivity of combined SS+US was 94.5% (86.8% and 80.4% for SS and US respectively). There was a significant (P&amp;lt;0.05, Student's t-test) difference in size between the PT glands correctly identified and undetected by SS, whereas the site of the removed PT tumors significantly (P&amp;lt;0.05, Fisher exact test) influenced only the US sensitivity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>When the preoperative localization of the PT glands is chosen, the combination of SS and US represents a reliable noninvasive localization technique and should be considered for use in each patient with pHPT undergoing surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1530\/eje.0.1430755","type":"journal-article","created":{"date-parts":[[2005,1,24]],"date-time":"2005-01-24T21:34:41Z","timestamp":1106602481000},"page":"755-760","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":122,"title":["Advantages of combined technetium-99m-sestamibi scintigraphy and high-resolution ultrasonography in parathyroid localization: comparative study in 91 patients with primary hyperparathyroidism"],"prefix":"10.1093","volume":"143","author":[{"given":"F","family":"Lumachi","sequence":"first","affiliation":[{"name":"Endocrine Surgery Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Zucchetta","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, Department of Diagnostic Medical Sciences, University of Padua, School of Medicine , via Giustiniani 2, 35128 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"Marzola","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, Department of Diagnostic Medical Sciences, University of Padua, School of Medicine , via Giustiniani 2, 35128 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Boccagni","sequence":"additional","affiliation":[{"name":"Department of Surgical and Gastroenterological Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Angelini","sequence":"additional","affiliation":[{"name":"Radiology Service, Padua City Hospital , 35128 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Bui","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, Department of Diagnostic Medical Sciences, University of Padua, School of Medicine , via Giustiniani 2, 35128 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D F","family":"D'Amico","sequence":"additional","affiliation":[{"name":"Department of Surgical and Gastroenterological Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Favia","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,12,1]]},"container-title":["European Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/143\/6\/755.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/143\/6\/755\/46357911\/755.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/143\/6\/755\/46357911\/755.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T10:45:21Z","timestamp":1676457921000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/143\/6\/755\/6750584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,12,1]]}},"URL":"https:\/\/doi.org\/10.1530\/eje.0.1430755","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2000,12]]},"published":{"date-parts":[[2000,12,1]]}}}