{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:33Z","timestamp":1787022813486,"version":"build-2736575974"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    : To measure serum levels of CXCL10 and CCL2 prototype chemokines of the two major subclass (CXC and CC) in patients with newly diagnosed chronic autoimmune thyroiditis (AT), and relate the findings to the clinical phenotype.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Design and methods<\/jats:italic>\n                    : Serum CXCL10 and CCL2 were assayed in 70 consecutive patients with newly diagnosed chronic AT, in sex- and age-matched healthy volunteers (\n                    <jats:italic>n<\/jats:italic>\n                    = 37) and in 20 patients with non-toxic multinodular goiter, extracted from a random sample of the general population from the same geographic area.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    : CXCL10 serum levels were significantly higher in patients with thyroiditis than in controls or multinodular goiter patients, while comparable CCL2 levels were found between groups. CXCL10 levels were significantly increased in hypothyroid patients and in those with an hypoechoic pattern (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0004 and\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0001, respectively) while serum CCL2 levels were significantly increased in patients older than 50 years and in those with hypothyroidism (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0001 and\n                    <jats:italic>P<\/jats:italic>\n                    = 0.03, respectively). No correlation between CXCL10 and CCL2 serum levels could be demonstrated. CXCL10 and CCL2 were studied separately in relation to clinical features of AT patients. Two separate multiple linear regression models for CXCL10 and CCL2 were performed, including age, thyroid volume, thyroid stimulating hormone (TSH), FT4, anti-thyroid peroxidase (AbTPO), hypoechoic pattern, and the presence of hypervascularity, demonstrating that ln of serum CXCL10 levels was associated with TSH independently of other possible confounders levels [regression coefficient (R.C.) 0.143 confidence interval (C.I.) (0.042\u20130.245);\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0059], while serum CCL2 were significantly associated only with age [R.C. 5.412 C.I. (3.838\u20136.986);\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001].\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    : Our results, obtained in a large cohort of newly diagnosed AT patients demonstrate increased CXCL10 especially in hypothyroid patients with a more aggressive disorder, and normal CCL2 serum levels in AT.\n                  <\/jats:p>","DOI":"10.1530\/eje.1.01847","type":"journal-article","created":{"date-parts":[[2005,2,14]],"date-time":"2005-02-14T15:57:41Z","timestamp":1108396661000},"page":"171-177","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":68,"title":["Increase of interferon-\u03b3 inducible \u03b1 chemokine CXCL10 but not \u03b2 chemokine CCL2 serum levels in chronic autoimmune thyroiditis"],"prefix":"10.1093","volume":"152","author":[{"given":"Alessandro","family":"Antonelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Rotondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poupak","family":"Fallahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Romagnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Martina","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Paolicchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ele","family":"Ferrannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Serio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"2","key":"1_6505807","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S1074-7613(00)80165-X","volume":"12","author":"Zlotnik","year":"2000","journal-title":"Immunity","ISSN":"https:\/\/id.crossref.org\/issn\/1074-7613","issn-type":"print"},{"issue":"5","key":"2_5797277","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/jlb.62.5.554","volume":"62","author":"Arenberg","year":"1997","journal-title":"Journal of Leukocyte Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0741-5400","issn-type":"print"},{"issue":"6824","key":"3_11059838","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/35065016","volume":"410","author":"M\u00a0\u00a0ller","year":"2001","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"5_25719721","first-page":"436","volume":"338","year":"2001","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"2","key":"6_17722927","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1046\/j.1365-2265.2003.01824.x","volume":"59","author":"Kemp","year":"2003","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"4","key":"7_35863074","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1084\/jem.187.4.601","volume":"187","year":"1998","journal-title":"Journal of Experimental Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1007","issn-type":"print"},{"issue":"11","key":"8_15664132","doi-asserted-by":"crossref","first-page":"4969","DOI":"10.4049\/jimmunol.153.11.4969","volume":"153","author":"Maghazachi","year":"1994","journal-title":"The Journal of Immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"issue":"2","key":"9_16213136","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/eji.1830260207","volume":"26","author":"Maghazachi","year":"1996","journal-title":"European journal of immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2980","issn-type":"print"},{"issue":"8","key":"10_16016072","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.4049\/jimmunol.155.8.3877","volume":"155","author":"Taub","year":"1995","journal-title":"The Journal of Immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"issue":"9","key":"11_16760274","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.4049\/jimmunol.158.9.4129","volume":"158","author":"Karpus","year":"1997","journal-title":"The Journal of Immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"issue":"6","key":"13_15826959","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1210\/edrv-15-6-788","volume":"15","author":"WEETMAN","year":"1994","journal-title":"Endocrine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0163-769X","issn-type":"print"},{"key":"14_25719723","first-page":"309","volume":"141","year":"1994","journal-title":"The Journal of Immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"issue":"2","key":"15_15563133","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1210\/jc.79.2.355","volume":"79","author":"Watson","year":"1994","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"16_16402274","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1046\/j.1365-2249.1996.d01-784.x","volume":"105","author":"Ajjan","year":"1996","journal-title":"Clinical and experimental immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9104","issn-type":"print"},{"issue":"12","key":"17_5884133","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1002\/eji.1830271228","volume":"27","author":"Roura-Mir","year":"1997","journal-title":"European journal of immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2980","issn-type":"print"},{"issue":"3","key":"18_5423300","first-page":"324","volume":"77","author":"Grubeck-Loebenstein","year":"1989","journal-title":"Clinical and experimental immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9104","issn-type":"print"},{"issue":"2","key":"19_9399056","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1365-2249.1991.tb05634.x","volume":"83","author":"Zheng","year":"1991","journal-title":"Clinical and experimental immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9104","issn-type":"print"},{"issue":"2","key":"20_16093648","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3109\/08916939509001930","volume":"20","author":"Kayser","year":"1995","journal-title":"Autoimmunity","ISSN":"https:\/\/id.crossref.org\/issn\/0891-6934","issn-type":"print"},{"issue":"1","key":"21_16032980","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1677\/jme.0.0150011","volume":"15","author":"Watson","year":"1995","journal-title":"Journal of Molecular Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0952-5041","issn-type":"print"},{"issue":"10","key":"22_11358472","doi-asserted-by":"publisher","first-page":"5008","DOI":"10.1210\/jc.86.10.5008","volume":"86","author":"GarcIa-Lopez","year":"2001","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"1","key":"23_17137123","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0002-9440(10)64171-5","volume":"161","author":"Romagnani","year":"2002","journal-title":"American Journal Of Pathology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"issue":"2","key":"24_16438704","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0014-5793(96)00935-0","volume":"394","author":"Kasai","year":"1996","journal-title":"FEBS Letters","ISSN":"https:\/\/id.crossref.org\/issn\/1873-3468","issn-type":"print"},{"issue":"8","key":"25_10921741","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1210\/jc.84.8.2873","volume":"84","author":"Ashhab","year":"1999","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"11","key":"26_17304881","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1053\/meta.2002.34717","volume":"51","author":"Kokkotou","year":"2002","journal-title":"Metabolism: clinical and experimental","ISSN":"https:\/\/id.crossref.org\/issn\/0026-0495","issn-type":"print"},{"issue":"2","key":"27_17621160","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF03345149","volume":"26","author":"Rotondi","year":"2003","journal-title":"Journal of endocrinological investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0391-4097","issn-type":"print"},{"issue":"6","key":"28_10752253","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1172\/JCI5150","volume":"103","author":"Sorensen","year":"1999","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"6","key":"29_11470145","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1046\/j.1468-1331.2001.00327.x","volume":"8","author":"S\u00a0\u00a0rensen","year":"2001","journal-title":"European journal of neurology : the official journal of the European Federation of Neurological Societies","ISSN":"https:\/\/id.crossref.org\/issn\/1351-5101","issn-type":"print"},{"issue":"1-2","key":"30_11094525","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/S0165-5728(01)00261-2","volume":"115","author":"Franciotta","year":"2001","journal-title":"Journal of neuroimmunology","ISSN":"https:\/\/id.crossref.org\/issn\/0165-5728","issn-type":"print"},{"issue":"3","key":"31_11432126","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1046\/j.1365-2249.2001.01683.x","volume":"126","author":"Antonelli","year":"2001","journal-title":"Clinical and experimental immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9104","issn-type":"print"},{"issue":"1","key":"32_9717721","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1530\/acta.0.1260013","volume":"126","author":"Antonelli","year":"1992","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"17","key":"33_10811091","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1001\/jama.281.17.1588","volume":"281","author":"Antonelli","year":"1999","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"issue":"5","key":"34_17717238","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1089\/105072503322021142","volume":"13","author":"Antonelli","year":"2003","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"key":"35_25719724","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/BF03349833","volume":"18","year":"1995","journal-title":"JOURNAL OF ENDOCRINOLOGICAL INVESIGATION"},{"issue":"1","key":"36_16936542","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1046\/j.1440-1711.2002.01062.x","volume":"80","author":"Lalor","year":"2002","journal-title":"Immunology and Cell Biology (Print)","ISSN":"https:\/\/id.crossref.org\/issn\/1440-1711","issn-type":"print"},{"issue":"5","key":"37_16927468","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.4049\/jimmunol.168.5.2470","volume":"168","author":"Wang","year":"2002","journal-title":"The Journal of Immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"issue":"4","key":"38_19670557","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1073\/pnas.020522597","volume":"97","author":"Caturegli","year":"2000","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"10","key":"39_6351727","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1089\/107999099313127","volume":"19","author":"Inadera","year":"1999","journal-title":"Journal of interferon &amp; cytokine research : the official journal of the International Society for Interferon and Cytokine Research","ISSN":"https:\/\/id.crossref.org\/issn\/1079-9907","issn-type":"print"},{"issue":"1-3","key":"40_10638703","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0047-6374(00)00200-1","volume":"121","author":"Pulsatelli","year":"2000","journal-title":"Mechanisms of ageing and development","ISSN":"https:\/\/id.crossref.org\/issn\/0047-6374","issn-type":"print"},{"issue":"12","key":"41_17329547","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1002\/1521-4141(2002012)32:12<3435::AID-IMMU3435>3.0.CO;2-O","volume":"32","author":"Goulvestre","year":"2002","journal-title":"European journal of immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2980","issn-type":"print"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/152\/2\/1520171.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/152\/2\/1520171.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T01:01:26Z","timestamp":1682989286000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/152\/2\/171\/6694670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":39,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/eje.1.01847","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}